Separation and extraction method of taurine

An extraction method and technology of taurine, applied in the direction of sulfonic acid preparation, chemical instruments and methods, preparation of organic compounds, etc., can solve problems affecting the quality of taurine, difficulty in extracting taurine, unfavorable total yield, etc. Achieve the effect of weak acidity, high solubility and high value

Inactive Publication Date: 2015-05-20
SHANDONG FANGMING PHARMACEUTICAL CO LTD
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Problems solved by technology

[0007] But in the technology of existing oxirane method synthetic taurine, all is to add sulfuric acid to neutralize, utilize the solubility characteristic of taurine and sodium sulfate to repeatedly carry out cooling crystallization centrifugation and concentrated hot filtration to obtain taurine and free respectively Sodium sulfate water, in this process, the obtained taurine mixed with sodium sulfate affects the quality of taurine, and the obtained sodium sulfate mixed with taurine affects the yield; concentrated at a...

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  • Separation and extraction method of taurine
  • Separation and extraction method of taurine

Examples

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Effect test

Embodiment 1

[0022] Example 1: First, react ethylene oxide and sodium bisulfite aqueous solution to prepare sodium isethionate solution, then dissolve it into inorganic ammonia, put it into a high-temperature and high-pressure reactor for ammoniation, and then remove it by flash evaporation Inorganic ammonia, obtained water evaporation liquid containing 33.5% taurine. Take 657g of the above evaporating liquid, control the temperature below 40°C under water bath cooling, gradually introduce sulfur dioxide, the system releases heat, and the material crystallizes gradually thickens. When the pH value reaches 6.5, stop ventilation and gradually cool down to 33°C. No inorganic salt crystallization, suction filtration, washing with a small amount of ice water, drying to obtain 135g of crude taurine, content 93% (yield 57.1%), the mother liquor was cooled to 0°C under stirring, and filtered with an 80-mesh sieve. Wash with a small amount of ice water to obtain 222g of sodium sulfite crystals (41....

Embodiment 2

[0023] Example 2: In a 2000ml flask, take 657g of the above evaporated liquid, add 1000ml of mother liquor frozen to 0°C to reclaim taurine and sodium sulfite, under water bath cooling, control the temperature below 40°C, gradually feed sulfur dioxide, and the system will release Heat, the material gradually crystallizes, stop ventilation when the pH reaches 6.5, and gradually cool down to 0°C, at this time, taurine and sodium sulfite crystallize at the same time, the taurine crystals are finer, and the sodium sulfite crystals are thicker, maintain 0°C, stop stirring and let stand After 1 minute, pour out the upper layer of turbid liquid from the flask, filter the taurine with a filter cloth, return the mother liquor to the flask for stirring, let stand, and then filter again. After repeating 4 times, the upper layer is already relatively clear. The filter cake was washed with water, and 206 g of crude taurine was dried, with a content of 94.5% (yield 88.5%). Filter all the fe...

Embodiment 3

[0024] Example 3: In a 1000ml flask, take 657g of the above evaporated liquid, under cooling in a water bath, control the temperature below 40°C, gradually feed sulfur dioxide, the system exotherms, and the material gradually crystallizes. When the pH reaches 5.0, stop the aeration, and gradually Cool down to 0°C, let taurine fully crystallize, sodium bisulfite does not crystallize, maintain 0°C, pour out the turbid liquid from the flask, filter taurine with filter cloth, wash the filter cake with a small amount of ice water, and dry The crude product of taurine is 199.8g, the content is 92.5% (84% yield). 539g of sodium bisulfite solution (32.5% content, 95.6% yield, 6.5% taurine content) was obtained.

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Abstract

The invention relates to a separation and extraction method of taurine. The separation and extraction method of taurine comprises following steps: oxirane is reacted with sodium bisulfite aqueous solution so as to obtain a sodium hydroxyethyl sulfonate solution; inorganic ammonia is dissolved into the sodium hydroxyethyl sulfonate solution, an obtained mixture is delivered into a pressure reactor for ammonification, and a sodium taurate aqueous solution is obtained via flash distillation; the sodium taurate aqueous solution is subjected to blending, and is reacted with neutralizer sulfur dioxide in a neutralization reactor until a reaction endpoint is reached. According to the separation and extraction method, at a relatively temperature, taurine solubility is relatively low, crystals are fine, and density is low; sodium sulfite is low in solubility and possesses crystal water, crystals are coarse, and density is high; sodium bisulfate is high in solubility, and crystallization is not easily caused at low temperature; so that separation of taurine with inorganic salts is realized via settling separation and sieve filtering at low temperature, excellent effects are achieved; by products, including sodium sulfite and sodium bisulfate, which are high in additional value are obtained; and recycling can be realized. The separation and extraction is safe and friendly to the environment, and can be used for industrialized production; cost is low; yield is high; quality is high; and energy consumption is low.

Description

technical field [0001] The invention relates to a method for separating and extracting taurine, which belongs to the field of fine chemicals. Background technique [0002] Taurine is also known as 2-aminoethanesulfonic acid, and its English name is Taurine. It is a sulfur-containing non-protein amino acid, which was first isolated from taurine, hence the name. This product exists in a free state in the body and does not participate in the synthesis of proteins in the body, but it is closely related to the metabolism of cystine and cysteine. The activity of cysteine ​​sulfite carboxylase (CSAD) that synthesizes taurine in the human body is low, and it mainly depends on the intake of taurine in food to meet the needs of the body. Taurine can improve nerve conduction and visual function, prevent cardiovascular disease, affect lipid absorption, improve endocrine status, enhance human immunity, affect glucose metabolism, inhibit the occurrence and development of cataract, impro...

Claims

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Application Information

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IPC IPC(8): C07C309/14C07C303/02C07C303/44
Inventor 王兴路方金印刘福明范兴山刘增韩涛王景立
Owner SHANDONG FANGMING PHARMACEUTICAL CO LTD
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