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A preparation method of supramolecular capsules with multiple stimulating drug release and MRI imaging capabilities

A multi-stimulatory, supramolecular technology for medical applications

Inactive Publication Date: 2018-09-21
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Recently, multiple systems combining light and temperature control, MMP-2 enzyme cleavage, etc. have been reported, but there are still few articles reporting triple response (pH, light, magnetic) systems

Method used

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  • A preparation method of supramolecular capsules with multiple stimulating drug release and MRI imaging capabilities
  • A preparation method of supramolecular capsules with multiple stimulating drug release and MRI imaging capabilities
  • A preparation method of supramolecular capsules with multiple stimulating drug release and MRI imaging capabilities

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Embodiment 1

[0037] 1. Materials

[0038] Polyallylamine hydrochloride (PAH, Mw ~ 15000), fluorescein isothiocyanate (FITC) were purchased from Sigma-Aldrich. Amantadine hydrochloride (AD), sodium polystyrene sulfonate (PSS, Mw ~ 70000) were purchased from J&K Bailingwei. Calcium Chloride (CaCl 2 ), potassium carbonate (K 2 CO 3 ), β-cyclodextrin (β-CD), p-toluenesulfonyl chloride (P-TsCl), acetone, methanol, triethylamine (TEA), N,N-dimethylformamide (DMF), phosphoric acid (H 3 PO 4 ), L-aspartic acid, sodium hydroxide (NaOH), hydrochloric acid (HCl), and ammonia were purchased from Sinopharm Reagent Company. Rhodamine B, dextran (MW ~ 70000), methacrylic acid (MAA), sodium borohydride (NaBH 4 ), azobisisobutyronitrile (AIBN), ferric chloride hexahydrate (FeCl.6H 2 O), ferrous chloride tetrahydrate (FeCl.4H 2 O), potassium periodate (KIO 4 ), ethylenediamine (EDA), and sodium ethylenediaminetetraacetate (EDTA) were purchased from Aladdin.

[0039] 2. Preparation of supramolecul...

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Abstract

The invention discloses a method for preparing a supermolecule capsule with multiple drug release stimulation and MRI radiography ability. A ferroferric oxide microcapsule is prepared as a novel multifunctional magnetic resonance noise and drug therapy medicament through a layer-by-layer self-assembly technology. Through the host-guest interaction and the Coulomb interaction of different supramolecular polymers, the medicine molecule is controllably released through the non-invasive ultraviolet radiation distributed azobenzene isomerism and the acid response Schiff base. Additionally the magnetic-targeted MRI contrast agent is obtained by encapsulating the superparamagnetic ferroferric oxide granule. The r2 relaxation rate of the microcapsule is increased by 37% to reach 125.71 mM-1S-1 compared with that of the neutral condition (92.02mM-1S-1) through the stimulation of subacidity (pH=5.6).

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for preparing supramolecular capsules capable of multiple stimulating drug release and MRI imaging. Background technique [0002] Cancer is one of the most serious public health problems in the world. According to the report of the World Health Organization, more than 15 million people will suffer from cancer before 2020, and two-thirds of them will die every year . Because most early-stage tumors can be treated effectively, it is very important to develop in vivo imaging techniques for tumor diagnosis. Magnetic resonance imaging (MRI) is an effective medical imaging method for tumor tissue imaging by detecting different proton relaxation rates in different parts, and the use of contrast agents can significantly enhance its contrast effect. However, traditional T1 contrast agents based on gadolinium complexes are highly toxic and expensive. Superparamagnetic nano-iro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/18A61K49/12A61K47/36A61K47/69A61K47/34A61K47/32A61K47/04A61K9/50A61K41/00A61P35/00
Inventor 徐祖顺郑迪威
Owner HUBEI UNIV
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