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Ultrasonic controlled release medicine elution balloon catheter and preparation method

A balloon catheter and controlled-release drug technology, which is applied to balloon catheters, drug devices, and other medical devices, etc., can solve problems such as potential safety hazards, poor drug release targeting, and failure to solve problems such as controllable and quantitative drug release. , to achieve the effect of increasing efficiency, reducing drug loss and increasing absorption efficiency

Active Publication Date: 2015-08-19
SHANDONG RIENTECH MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Directly coating the drug on the surface of the balloon can only improve the drug absorption of the lesion by increasing the drug loading on the surface of the balloon. The drug release is poorly targeted, and the drug release cannot be quantified and effectively controlled, and there are potential safety hazards.
CN1124165A discloses a liposome balloon catheter carrying genes and therapeutic drugs. This patent uses liposomes as drug inclusions, which reduces the loss of drugs in the blood to a certain extent, but still relies on physical contact or similar The principle of passive diffusion into the tissue does not solve the problem of controllable and quantitative release of drugs in the lesion

Method used

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  • Ultrasonic controlled release medicine elution balloon catheter and preparation method

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Embodiment approach

[0039] The invention provides a drug-eluting balloon catheter with controllable drug release site and drug release amount, and a preparation method thereof. in:

[0040] 1. Surface modification of ordinary balloon catheters

[0041] This step can improve the firmness and drug loading capacity of the drug coating on the surface of the balloon catheter, but it is not a necessary step for the preparation of the drug-eluting balloon catheter.

[0042] Plasma immersion treatment is performed on the balloon segment of a common balloon catheter to promote adhesion of the anti-proliferative drug coating. The specific steps are: place the catheter in the plasma immersion ion implantation device, after vacuuming, inject hydrogen, nitrogen, water vapor or ammonia gas, the gas pressure is 0.05-50 Pa; the radio frequency discharge power is 200-1200W; Pulse high-voltage power supply amplitude 1KV ~ 100KV, frequency 50 ~ 40000 Hz or AC power supply 10-20 MHz, duty cycle 3% ~ 80%; heating ...

Embodiment 1

[0057] At room temperature, a 5 mg / ml aqueous solution of PEG2000 was prepared as a dispersant. Add PLGA drug-loaded microcapsules with a certain wall thickness (PLGA: docetaxel = 1:1) to the above-mentioned aqueous dispersant at a mass ratio of 1:1 to PEG2000 in the dispersant, shake until uniformly dispersed, and make a drug-loaded coating Material. Prepare the drug-loaded coating on the surface of the common balloon catheter by the above-mentioned spraying / soaking method;

Embodiment 2

[0059] Dispersant is the ethanol solution of 5mg / mlPEG2000, and other conditions are with embodiment 1;

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Abstract

The invention discloses an ultrasonic controlled release medicine elution balloon catheter and a preparation method. The surface of the medicine elution balloon catheter is coated with a medicine coating, the medicine coating is composed of a fat-soluble medicine carrying microcapsule having a ultrasonic response characteristic and an adhesive having a water-soluble characteristic. Medicine of the medicine elution balloon catheter is wrapped in a lipophilic medicine carrying microcapsule which is hard to dissolve in the blood, so medicine loss caused by blood washing can be reduced. When the ultrasonic controlled release medicine elution balloon catheter is used, the medicine elution balloon catheter is sent to a lesion portion and unfolds, a balloon contacts with the lesion tissues, ultrasound inducts the lesion portion at the external, the medicine carrying microcapsule can be speeded up to be separated from the hydrophilic adhesive, medicine can diffuse in the fat-soluble lesion tissues, at the same time, the medicine carrying microcapsule having the ultrasonic response characteristic breaks under the function of the ultrasound and discharges the medicine, the efficiency of medicine absorption and utilization by the target lesion tissues can be greatly raised. The amount and time of medicine discharge can be controlled through adjusting the characteristic and the ultrasonic characteristic of the medicine carrying microcapsule, the validity and safety of the medicine elution balloon catheter can be improved.

Description

technical field [0001] The invention relates to the field of medical instruments. In particular, it relates to an ultrasonic controlled-release drug-eluting balloon catheter and a preparation method thereof. Background technique [0002] Coronary heart disease is a major disease that threatens human health. At present, the safest and most effective way to treat this disease is cardiovascular interventional therapy (PCI). [0003] Cardiovascular interventional therapy has experienced three stages of development since its appearance in the 1970s: [0004] 1. In 1977, human beings used balloons for the first time to treat coronary artery stenosis. Although the balloon can eliminate coronary stenosis, the elastic retraction of the vessel wall, hyperplasia of the intimal layer, and tearing of the intimal wall of the vessel wall can promote restenosis, and the restenosis rate of the target vessel 3-6 months after surgery Up to 30%-50%; [0005] 2. Bare metal stent (BMS) came o...

Claims

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Application Information

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IPC IPC(8): A61M25/10A61M31/00
Inventor 张海军王身国杨飞周超常立娜
Owner SHANDONG RIENTECH MEDICAL TECH
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