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Composition of egcg and chitosan oligosaccharide and its preparation method and application

A technology of chitosan oligosaccharide and prescription is applied in the field of the composition of EGCG and chitosan oligosaccharide, which can solve the problems of weak curative effect of chitosan oligosaccharide, unfavorable and hidden dangers of preparation use safety, adverse effects on product preparation, storage and circulation, etc.

Active Publication Date: 2018-09-25
无锡解你食品技术研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the disadvantage is that EGCG has poor stability and is easily affected by factors such as temperature, water, pH, etc., especially when it is stored in a liquid environment for 7 days, its hydrolysis / degradation rate reaches more than 17%, even in a solid state, Although the stability will be relatively improved, it is more sensitive to temperature and will gradually degrade in a hot environment, which will seriously affect the product quality and the development of EGCG preparations / products, and have serious adverse effects on the preparation, storage, and circulation of products. The safe use of chitosan brings disadvantages and hidden dangers; on the other hand, the curative effect of chitosan oligosaccharides is relatively weak, and it is usually necessary to use a compound form to improve its curative effect

Method used

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  • Composition of egcg and chitosan oligosaccharide and its preparation method and application
  • Composition of egcg and chitosan oligosaccharide and its preparation method and application
  • Composition of egcg and chitosan oligosaccharide and its preparation method and application

Examples

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Comparison scheme
Effect test

Embodiment 1

[0235] Example 1. Compound tablets of EGCG and oligochitosan and their preparation

[0236] The prescription quantity is calculated by weight percentage and contains:

[0237] EGCG 8%~35%, preferably 30%,

[0238] Chitooligosaccharides 15%-50%, preferably 50%,

[0239] Mannitol 10%-40%, preferably 12%,

[0240] Sodium carboxymethyl starch 1%-10%, preferably 5%,

[0241] Hydroxypropyl cellulose aqueous solution appropriate amount, preferably 2.5% hydroxypropyl cellulose aqueous solution, 2% based on hydroxypropyl cellulose,

[0242] Magnesium stearate 0.5% to 2%, preferably 1%;

[0243] The preparation method includes: passing EGCG, oligochitosan, mannitol, and sodium carboxymethyl starch through an 80-mesh sieve, preferably 100-mesh, after weighing according to the prescription, mixing the EGCG and oligochitosan evenly, adding mannitol and Sodium carboxymethyl starch, after mixing uniformly, add hydroxypropyl cellulose aqueous solution to make soft material, and granulate through 24 mesh ...

Embodiment 2

[0248] Example 2. Compound granules of EGCG and oligochitosan and their preparation

[0249] The prescription quantity is calculated by weight percentage and contains:

[0250] EGCG 0.5%-10%, preferably 1%,

[0251] Chitooligosaccharides 0.5%-20%, preferably 1.5%,

[0252] Granule auxiliary material 85%~99%, preferably 97.5% fructose;

[0253] Wherein the granule auxiliary materials include one or more of the following ingredients: fructose, xylitol, oligofructose, polyfructose, xylo-oligosaccharide, polydextrose, mannitol, sucrose, invert sugar (ie glucose and fructose Mixtures of the same amount), glucose, resistant dextrin, sorbitol, maltose, isomalt, oligomannose, solid polyethylene glycol (such as polyethylene glycol-4000, polyethylene glycol-12000 , Polyethylene glycol-6000, polyethylene glycol-2000, etc.), dextrin, cyclodextrin, maltodextrin, hydroxypropyl-β-cyclodextrin, microcrystalline cellulose, carboxymethyl cellulose, hydroxy Propylmethyl cellulose, pregelatinized starch...

Embodiment 3

[0259] Example 3. Compound capsules of EGCG and oligochitosan and their preparation

[0260] The prescription quantity is calculated by weight percentage and contains:

[0261] EGCG 10%-30%, preferably 25%,

[0262] Chitooligosaccharides 15%-45%, preferably 30%,

[0263] Mannitol 15%-35%, preferably 23%,

[0264] Pregelatinized starch 8%-25%, preferably 15%,

[0265] Sodium carboxymethyl starch 1%-15%, preferably 5%,

[0266] A proper amount of polyvinylpyrrolidone in ethanol, preferably 1% polyvinylpyrrolidone,

[0267] Magnesium stearate 0.5% to 2%, preferably 1%;

[0268] The preparation method includes: passing EGCG, oligochitosan, mannitol, pregelatinized starch, and sodium carboxymethyl starch through an 80-mesh sieve, preferably a 100-mesh sieve. The sugar is mixed uniformly to obtain A mixed powder, which is ready for use; in addition, mannitol, pregelatinized starch, and sodium carboxymethyl starch are mixed uniformly to obtain B mixed powder, and then the A mixed powder and the B...

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Abstract

The invention provides an EGCG (epigallocatechin gallate) and chitosan oligosaccharide pharmaceutical composition. The EGCG and chitosan oligosaccharide pharmaceutical composition can be of pharmaceutically acceptable any dosage form, wherein EGCG and chitosan oligosaccharide are combined according to a weight ratio of (0.1-2): 1. The invention further provides a preparation method of the composition, as well as an application of the composition in preparing medicaments for lowering blood lipid and protecting heart and cerebral vessels and an application of the composition in preparing medicaments for resisting tumors.

Description

Technical field [0001] The invention relates to a health product composition, and a preparation method and application thereof, in particular to a composition of EGCG and chitooligosaccharides, and a preparation method and application thereof. The health product composition of the present invention includes but is not limited to medicines, medical foods, health foods or functional foods, ordinary foods and the like. Background technique [0002] EGCG, namely epigallocatechin gallate, the structural formula is as follows, [0003] , [0004] EGCG is a natural compound extracted and isolated from green tea. It is the most efficient active monomer component of tea polyphenols. It has good safety and extensive physiological activity. Studies have shown that EGCG has anti-thrombotic and anti-thrombotic properties. Arteriosclerosis, protection of the nervous system, anti-free radical damage, anti-oxidation, anti-oxidative stress, anti-vascular proliferation, regulation of immunity, prot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61K9/20A61K9/16A61K9/48A61P3/06A61P9/00A61P35/00A23L33/125A23L33/105A61K31/353
Inventor 张耿元王保红唐湘成白东跃
Owner 无锡解你食品技术研究院有限公司