A kind of preparation method of palbociclib

A compound and reaction technology, applied in the field of preparation of palbociclib, can solve the problems of increasing the synthesis cost, etc., and achieve the effects of less waste, improved purity and yield, and high yield

Active Publication Date: 2017-01-04
SHANDONG LUOXIN PHARMA GRP CO LTD
View PDF10 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The disadvantage of this synthetic route is that the Heck reaction is used twice, which requires the use of noble metal palladium chloride or palladium acetate, and more expensive ligands, which increases the cost of synthesis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of palbociclib
  • A kind of preparation method of palbociclib
  • A kind of preparation method of palbociclib

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: the synthesis of compound IV

[0032] 1) Add 2-acetyl-2-butenoic acid methyl ester and N-[5-(1-piperazinyl)-2-piperidinyl]guanidine (compound III, 62.8g, 300mmol) and methanol 100mL In the CW-2000 ultrasonic-microwave reactor, add 16.4g of sodium methoxide dropwise at room temperature in 100mL of methanol solution, and stir for 15 minutes; add 11.9g of malononitrile and 2-acetyl-2-butenoic acid form Esters (21.3g, 150mmol) in 100mL of methanol solution, controlled microwave power: 100W, microwave frequency: 2450MHz, ultrasonic power: 50W, ultrasonic frequency: 20KHz, set the reaction temperature at 50°C, and the reaction time was 10min. TLC detected that the reaction was complete. A large amount of solids precipitated under ice bath, filtered with suction, washed the filter cake with a small amount of water, added ethanol and diethyl ether (1:1, V / V) for recrystallization, and dried in vacuo to obtain 57.0 g of compound IV with a yield of 95.8% and a purit...

Embodiment 2

[0034]Embodiment 2: the synthesis of compound V

[0035] 1) Add 21.2g (200mmol) of sodium dihydrogen hypophosphite, 100mL of water, 19.6g of concentrated sulfuric acid, and 39.6g (100mmol) of compound IV into the three-necked flask in sequence, and slowly add an aqueous solution of sodium nitrite (200mmol, 13.8 grams of sodium nitrite are dissolved in 10 milliliters of water), and the temperature of the control reaction system is lower than 0°C. After the dropwise addition was complete, stirring was continued for 4 hours. The reaction solution was extracted with ethyl acetate, and the ethyl acetate was recovered by rotary evaporation to obtain crude compound V; recrystallized from isopropanol to obtain 30.7 g of white crystal compound V with a product yield of 80.6% and a purity of 98.6% (HPLC).

[0036] 2) Add 31.8g (300mmol) of sodium dihydrogen hypophosphite, 100mL of water, 39.2g of concentrated sulfuric acid, and 39.6g (100mmol) of compound IV into the three-necked flask...

Embodiment 3

[0037] Embodiment 3: the synthesis of compound VI

[0038] 1) Add 38g (100mmol) of compound V, 11.5g of cyclopentane chloride, 14.2g of triethylamine, 0.072g of cuprous bromide, 0.099g of 1,10-phenanthroline and N,N-dimethyl 100 mL of methyl formamide, heated to 100°C, and stirred for 90 minutes. TLC detects that the reaction is complete. Add 200ml of water and stir evenly, solids are precipitated, suction filtered, and the obtained crude product is recrystallized with n-hexane and ethyl acetate (2:1, V / V), dried in vacuo to obtain 39.9 g of off-white solid compound VI; yield 88.7%, Purity 99.8% (HPLC method).

[0039] 2) Add 30.4g of compound V, 9.4g of chlorocyclopentane, 13.8g of anhydrous potassium carbonate, 0.057g of cuprous bromide, 0.079g of 1,10-phenanthroline and N,N-dimethyl 100 mL of methyl formamide was heated to 90°C, and the reaction was stirred for 120 minutes. TLC detects that the reaction is complete. Add 200ml of water and stir evenly, solid precipitate...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of pharmaceutical and chemical engineering, and particularly relates to a preparation method of palbociclib. 2-acetyl-2-butenoic acid methyl ester, malononitrile and a guanidino compound III are reacted together according to an ultrasonic-microwave assisted synthesis method, and a compound IV is rapidly obtained with a high yield; then, sodium nitrite and hypophosphorous acid are subjected to a deamination reduction reaction to generate a compound V; then, the compound V and cyclopentane halide are subjected to a coupled reaction under the action of a catalyst to generate a compound VI; finally, a dehydrogenation reaction is conducted under the action of a catalyst TPND to obtain the palbociclib. The method has the advantages that reaction conditions are mild, the technological process is simple and reasonable, reaction time is short, aftertreatment is easy, product quality is high, and the yield is high.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and in particular relates to a preparation method of palbociclib. Background technique [0002] Palbociclib is an oral cyclin-dependent kinase (CDKs) 4 and 6 inhibitor developed by Pfizer. The indication is combined with letrozole for the treatment of estrogen receptor positive, human epidermal growth factor receptor 2 negative (ER+ / HER2-) postmenopausal patients with advanced breast cancer, as an initial endocrine therapy-based regimen for the treatment of metastatic disease . The CAS number of Palbociclib is [571190-30-2], the chemical name is: 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl) Pyridin-2-yl]amino]-8H-pyrido[2,3-D]pyrimidin-7-one, the structural formula is as follows: [0003] [0004] WO2003062236 reported the synthesis method of palbociclib. WO2010039997 and WO2012068381 adopted the same synthesis route with improved yield. The synthesis route is as foll...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07D471/04
CPCC07D471/04
Inventor 袁雪徐阳李修珍
Owner SHANDONG LUOXIN PHARMA GRP CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap