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Polylactic acid/nanometer beta-tricalcium phosphate composite porous bracket and preparation method thereof

A porous scaffold, tricalcium phosphate technology, applied in pharmaceutical formulations, medical science, prostheses, etc., can solve problems such as difficulty in meeting the ideal requirements of bone defect repair materials, mismatch between degradation rate and bone growth, and insufficient elastic modulus. Achieving good osteoconductivity, beneficial to repair and improving osteogenic activity

Inactive Publication Date: 2016-11-23
花沐医疗科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when the current clinical β-TCP product is used alone, there are still problems that urgently need to be improved, such as the mismatch between the degradation rate and the bone growth, high brittleness and insufficient elastic modulus.
[0005] Single organic or inorganic materials are difficult to meet the ideal requirements of bone defect repair materials, and the development of composite materials of PLA and β-TCP has become a hot spot

Method used

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  • Polylactic acid/nanometer beta-tricalcium phosphate composite porous bracket and preparation method thereof
  • Polylactic acid/nanometer beta-tricalcium phosphate composite porous bracket and preparation method thereof
  • Polylactic acid/nanometer beta-tricalcium phosphate composite porous bracket and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 nanoscale β-tricalcium phosphate

[0036] 1) Prepare micron-sized β-TCP particles that meet the β-TCP standard for surgical implants as raw materials;

[0037] 2) Disperse micron-sized β-TCP particles in a diethylene glycol dispersion, use zirconia beads as the ball milling medium, and continuously ball mill at a speed of 1800r / min for 12 hours;

[0038] 3) Centrifuge to remove diethylene glycol dispersion;

[0039] 4) Rinse with dichloromethane, dry in vacuum, and store.

Embodiment 2

[0040] Embodiment 2 transmission electron microscopy and dynamic light scattering analysis verification

[0041] The particle size of the β-TCP particles prepared in Example 1 was observed by a H-7000 transmission electron microscope, and the acceleration voltage used was 75KV. The particle size of the prepared β-TCP particles was tested by dynamic light scattering. The Zetasizer Nano-ZS potential and particle size analyzer was used to determine the particle size and Zeta potential of polymer drugs. Particle size measurement parameters: He-Ne laser (wavelength 635nm), refractive index and viscosity are n=1.333 and η=0.933cp respectively, measurement temperature is 25°C. Potential measurement parameters: He-Ne laser (wavelength 635nm), scattering angle θ=14°, measurement temperature 25°C.

[0042] Observing the prepared nano-sized β-TCP particles by TEM, the particles are in irregular shape, and the particle size range is 20-160nm (such as figure 1 A, B). Observation by dyn...

Embodiment 3

[0043] Example 3 Preparation of polylactic acid / nano β-tricalcium phosphate composite porous scaffold

[0044] 1) Accurately weigh a certain amount of PLA and dissolve it in dioxane to make a 1.5wt% PLA solution, and weigh 1:9, 3:7 and 5:5 mass ratios according to the PLA mass (PLA:nano Nano-sized β-TCP particles with a mass ratio of 3:7 (PLA: micron-sized β-TCP) were weighed in the same method, and added to the PLA solution that had been prepared, and the Stir and mix for one minute to make it evenly mixed, ultrasonically disperse for 40 minutes, and stir evenly;

[0045] 2) Pour the solution into a special polytetrafluoroethylene mold (bottom diameter 11mm, height 22mm) and then quench it with liquid nitrogen;

[0046] 3) Place the quenched polytetrafluoroethylene mold in step 2) in a low-temperature refrigerator at -30°C for 24 hours, and then dry it in a freeze dryer at -55°C for 1 day;

[0047] 4) Take it out from the mold and put it into a beaker, wash it with distille...

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Abstract

The invention discloses a polylactic acid / nanometer beta-tricalcium phosphate composite porous bracket and a preparation method thereof. A porous material is directly prepared by adopting a solution freeze-drying method; a pore-foaming agent does not need to be added, so that safety and reliability are realized; impurities are unlikely to enter in the processing process. The prepared porous bracket is appropriate in pore size, porosity and mechanical properties and has the degradability; meanwhile, due to the attachment of beta-TCP, the osteo-conduction is good. The degradable porous material can be implanted into a bone defect site in the orthopedic trauma, neoplasm, infection and congenital malformation operations, and the bone ingrowth and the material degradation through the appropriate pore size; meanwhile, the osteo-conduction is facilitated through the contained beta-TCP so as to promote the bone defect repair.

Description

technical field [0001] The invention belongs to the field of orthopedic implant materials, in particular to a polylactic acid / nano β-tricalcium phosphate composite porous scaffold and a preparation method thereof. Background technique [0002] The repair of bone defects caused by trauma, tumor, infection and congenital malformation is a clinical problem in orthopedics. The current clinical use of autologous bone, allogeneic bone and xenograft bone has certain limitations. The development of materials science has opened up new ways for bone defect repair. [0003] Polylactic acid (PLA) is the most commonly used degradable material in biomaterial research. The final products of metabolism are water and carbon dioxide, which can be absorbed and metabolized by the body. It has good biocompatibility and mechanical strength. It has been regulated by the US Food and Drug Administration. Food and Drug Administration (FDA) approved synthetic polymer materials that can be used as me...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/56A61L27/58
CPCA61L27/46A61L27/56A61L27/58A61L2400/12A61L2430/02C08L67/04
Inventor 董健曹露江立波陈谦李熙雷周晓岗殷潇凡
Owner 花沐医疗科技(上海)有限公司
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