Alginate medical dressing and preparation method thereof

Abstract

The invention relates to the technical field of medical articles, in particular to alginate medical dressing and a preparation method thereof. The medical dressing is prepared by soaking alginate fibers in a functional soaking solution, wherein the functional soaking solution is prepared from, by weight, 2-4% of carboxymethyl chitosan, 1-2% of oligochitosan, 3-6% of chitosan hydrochloride, 1-2% of hyaluronic acid chitosan, 0.03-0.05% of antibacterial agent, 0.5-5% of sodium carboxymethyl cellulose, 1-6 % of calcium chloride, 0.005-0.05% of epidermal growth factor, 0.02-0.05% of aloe extracts and the balance water. The chitosan substances, the antibacterial agent, carboxymethyl cellulose, calcium chloride, the epidermal growth factor and the aloe extracts are loaded in the alginate fibers, so that the medical dress is endowed with the remarkable effects of preventing bacteria, stopping bleeding, promoting healing, preventing wound adherence and preventing scars.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to an alginate medical dressing and a preparation method thereof. Background technique [0002] The skin is an important organ of the human body and plays a protective role for the human body. Skin damage will cause a series of problems in the body, such as bacterial infection, increased metabolism, excessive loss of water and protein, endocrine and immune system dysfunction, etc., which may be life-threatening in severe cases. Therefore, after skin injury, medical dressings are usually used to protect the wound, prevent wound infection and severe dehydration, provide a moist environment conducive to wound healing, and promote wound healing. [0003] Alginate is a kind of natural linear polysaccharide mainly extracted from brown algae. It is non-toxic, biodegradable, and has high biocompatibility. The high hygroscopicity and gelation of alginate make it widely used in mode...

AI Technical Summary

Problems solved by technology

Such as Chinese patent 200680051180.X antibacterial alginate preparation, which contains at least one alginate and at least one antibacterial active substance selected from the group including biguanide derivatives, octidine and mebidiazine; However, the antibacterial alginate preparation has a single function, only contains antibacterial ingredients, has limited ability to absorb exudate, has no anti-adhesive ingredients, and the auxiliary materials are easy to stick to the wound and are not easy to replace

Chinese patent 201110366674X discloses a silver-loaded alginic acid fiber and its preparation method. It discloses that nano-silver is loaded on the alginic acid fiber by impregnation and washed with an organic solvent to obtain a fiber with good bulkiness and strong bactericidal effect. Alginic acid fiber; however, the alginic acid fiber is easy to cause organic solvent residue after washing with organic solvents, there is a risk of biocompatibility, and there is a great hidden danger to human safety. , no anti-adhesive ingredients, the auxiliary materials are easy to stick to the wound, and it is not easy to replace

Chinese patent 201510055030.7 discloses a preparation method of a highly antibacterial alginate auxiliary material. After activating the surface of the alginate fiber with an organic solvent, grafting a quaternization agent improves the antibacterial performance of the alginate, but the absorption of the auxiliary material The seepage ability is limited, the function is single, and toxic reagents such as methanol, acetone, hydrogen peroxide, and ferrous ammonium sulfate are used in the preparation process, and the biocompatibility test of the product has not been carried out, which has a greater safety hazard to the human body

Chinese patent CN201510402076.1 discloses an alginate dressing containing a composite silver-zinc antibacterial agent and its preparation method. The dressing improves its antibacterial and therapeutic effects by adding a composite silver-zinc antibacterial agent, but its ability to absorb exudate is limited. Single function, no anti-adhesion ingredients, easy to adhere to the wound surface, increase the difficulty of dressing change, and bring secondary damage to patients

In recent years, there have been some applications of chitosan in alginate dressings, such as Chinese patent 201210020699.9, which discloses a kind of alginate antibacterial dressing and its preparation method, by applying soluble alginate, water-soluble chitosan derivatives or Water-soluble chitin derivatives are used to prepare the spinning stock solution, and at the same time, silver-based antibacterial agents are added to the coagulation bath, and the blended fiber products are obtained by spinning, and the alginate antibacterial dressing is further prepared, which has the effect of sterilizing and promoting wound healing, but The dressing does not contain anti-adhesion ingredients, which is easy to adhere to the wound surface, making it difficult to change the dressing and causing secondary damage to the patient

As Chinese patent 201410340635.6 discloses sodium alginate-sodium carboxymethylcellulose-chitosan wound dressing and preparation method thereof, the components of the dressing are sodium alginate, sodium carboxymethylcellulose, chitosan, Glycerin and calcium chloride, but the wound healing effect of the dressing and the effect of preventing scarring can not meet the clinical application

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