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Cup [4] thiourea coumarin chemical sensor and preparation method and application thereof

A chemical sensor, coumarin technology, applied in chemical instruments and methods, analysis by making materials undergo chemical reactions, organic chemistry, etc., can solve problems such as inapplicability, achieve low detection limit, easy control of reaction conditions, and post-processing Handle simple effects

Inactive Publication Date: 2018-08-10
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Many commonly used analytical methods, such as ultraviolet-visible spectroscopy (UV-Vis), cyclic voltammetry (CV), nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR), are not applicable to F - Determination of

Method used

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  • Cup [4] thiourea coumarin chemical sensor and preparation method and application thereof
  • Cup [4] thiourea coumarin chemical sensor and preparation method and application thereof
  • Cup [4] thiourea coumarin chemical sensor and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Synthesis of Chemosensor L:

[0039] (1) Add calix[4]arene tetra-n-butyl ether powder (25.0g, 38.0mmol), dichloromethane (600mL), and glacial acetic acid (120mL) successively into a 250mL three-necked flask, and slowly drop them with a constant pressure dropping funnel Add a mixed solution of 65% nitric acid (50mL) and glacial acetic acid (100mL), the color of the system gradually changes from wine red to black, stir at room temperature for 1h, add water (600mL) to quench the reaction, stir, fully mix and shake, then separate the liquid, water The layer was extracted with dichloromethane (3×50 mL), and the combined organic phases were washed with water (2×200 mL) and saturated brine (2×200 mL) successively, and dried over anhydrous sodium sulfate. After evaporation and concentration, a viscous solid was obtained, which was heated and dissolved by adding a small amount of dichloromethane, poured into methanol solution under constant stirring, and a white solid was precip...

Embodiment 2

[0048] With reference to the method of Example 1, step (1) nitric acid and acetic acid with a volume ratio of 1:1 participated in the reaction, and the yield of the product was 25%.

Embodiment 3

[0050] With reference to the method of Example 1, step (1) nitric acid and acetic acid volume ratio 1:3 participated in the reaction, and the yield of the product was 22%.

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Abstract

The invention belongs to the field of supermolecular fluorescent probes and particularly relates to a fluorescent probe for detecting F<-> and a preparation method and an application of the fluorescent probe. The invention particularly relates to a cup [4] thiourea coumarin chemical sensor capable of identifying F<->. The preparation method is as follows: nitryl is introduced on the calixarene through the nitration reaction, then Raney-Li and hydrazine hydrate reflux in methyl alcohol to reduce nitryl into amino, aminocoumarin and thiophosgene form isothiocyanate coumarin, and the calixarene and the isothiocyanate coumarin are aminated to obtain a target product at high yield. The synthesis process is relatively simple, the reaction condition is easy to control, and the optical property and the optical stability of the prepared fluorescent probe are excellent. The fluorescent probe is used to detect the fluorinion.

Description

technical field [0001] The invention belongs to the field of supramolecular chemical sensors, in particular to a calix[4]thiourea coumarin chemical sensor and its preparation method and application. Background technique [0002] Fluoride ions play an important role in human life and food health. They can be used as food additives, essential elements for the human body, and play an important role in bone growth and dental health. However, excessive intake of fluoride ions by the human body will cause bone diseases such as osteoporosis and osteosarcoma. Fluoride is easily absorbed by the human body, but it is difficult to metabolize through the human body. Excessive exposure of the human body to fluoride can cause stomach cancer and some kidney diseases. In some underdeveloped countries, excessive fluoride in drinking water will lead to fluoride poisoning in the human body and cause a series of bone diseases. Therefore, it is of great significance to detect fluoride ions in ...

Claims

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Application Information

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IPC IPC(8): C07D311/16C09K11/06G01N21/64G01N21/78
CPCC07D311/16C09K11/06C09K2211/1011C09K2211/1088G01N21/6428G01N21/78G01N2021/6432
Inventor 李正义殷乐苏宏魁肖唐鑫孙小强
Owner CHANGZHOU UNIV
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