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Preparation method of pH-responsive photonic crystal gel base for skin wound treatment

A photonic crystal and responsive technology, which is applied in medical science, bandages, etc., can solve the problems of inconvenient observation of wound healing and changes, inability to directly observe the degree of wound infection, large load, etc., and achieve good sterilization and treatment effects. Biosafety, convenient administration effect

Active Publication Date: 2019-11-08
ZHEJIANG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention is to overcome the hydrogel with antibacterial effect loaded with nano-silver in the prior art, in order to have a good anti-bacterial effect, the required nano-silver loading is large or the dosage required for use is high, and the cost is relatively high; Moreover, when the hydrogel with antibacterial effect in the prior art is used for the treatment of skin wounds, the degree of infection of the wound cannot be directly observed, and it is not convenient to observe the healing and changes of the wound. A pH response for skin wound treatment is provided. The preparation method of type photonic crystal gel base, prepares CS / PAA / nanometer Cu 2 WS 4 Composite hydrogel and load pH-responsive photonic crystal matrix, the obtained pH-responsive photonic crystal gel matrix not only has good biological safety, but also can effectively treat wound infection and promote wound healing at a lower dose. ability; and because the wound infection is weakly acidic, the pH-responsive photonic crystal base can perform color reaction under Bragg diffraction, and the human eye can observe it naked

Method used

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  • Preparation method of pH-responsive photonic crystal gel base for skin wound treatment
  • Preparation method of pH-responsive photonic crystal gel base for skin wound treatment
  • Preparation method of pH-responsive photonic crystal gel base for skin wound treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Chitosan, acrylic acid, N,N′-methylenebisacrylamide and Cu with a mass ratio of 5:8:10:0.01 2 WS 4 Soluble in 1% acetic acid solution, after fully dissolved, deoxygenate with nitrogen for 30 minutes;

[0040] (2) Add 2,2-azobis(2-methylpropionamidine) dihydrochloride with a mass ratio of 1:30 to chitosan, seal it and put it under ultraviolet light to react, and the irradiation intensity is 400mW / cm 2 , the reaction time is 40min;

[0041] (3) Soak the obtained product in deionized water, change the water every 4 hours, repeat 10 times, and then cut the obtained product into 1cm 2 Small pieces of CS / PAA / nano-Cu were obtained after freeze-drying 2 WS 4 Composite hydrogel;

[0042] (4) Dissolve azobisisobutyronitrile, styrene monomer and polyvinylpyrrolidone in a mixed solvent of ethanol and water, azobisisobutyronitrile, styrene monomer, polyvinylpyrrolidone, ethanol and water The mass ratio of the mixture is 0.15:4:1:50:15, stirred evenly and deoxygenated by ...

Embodiment 2

[0049] (1) Chitosan, acrylic acid, N,N′-methylenebisacrylamide and Cu with a mass ratio of 15:9:12:0.05 2 WS 4 Soluble in 1.5% acetic acid solution, after fully dissolved, deoxygenate with nitrogen for 30 minutes;

[0050] (2) Add 2,2-azobis(2-methylpropionamidine) dihydrochloride with a mass ratio of 1:40 to chitosan, seal it and put it under ultraviolet light to react, the irradiation intensity is 450mW / cm 2 , the reaction time is 30min;

[0051] (3) Soak the obtained product in deionized water, change the water every 4.5h, repeat 15 times, and then cut the obtained product into 1cm 2 Small pieces of CS / PAA / nano-Cu were obtained after freeze-drying 2 WS 4 Composite hydrogel;

[0052] (4) Dissolve azobisisobutyronitrile, styrene monomer and polyvinylpyrrolidone in a mixed solvent of ethanol and water, azobisisobutyronitrile, styrene monomer, polyvinylpyrrolidone, ethanol and water The mass ratio of the mixture is 0.17:5:1:55:20, stirred evenly and deoxygenated by nitr...

Embodiment 3

[0059] (1) Chitosan, acrylic acid, N,N′-methylenebisacrylamide and Cu with a mass ratio of 25:10:15:0.1 2 WS 4 Soluble in 2% acetic acid solution, after fully dissolved, deoxygenate with nitrogen for 30 minutes;

[0060] (2) Add 2,2-azobis(2-methylpropionamidine) dihydrochloride with a mass ratio of 1:50 to chitosan, seal it and put it under ultraviolet light to react, and the irradiation intensity is 500mW / cm 2 , the reaction time is 20min;

[0061] (3) Soak the obtained product in deionized water, change the water every 5 hours, repeat 20 times, and then cut the obtained product into 1cm 2 Small pieces of CS / PAA / nano-Cu were obtained after freeze-drying 2 WS 4 Composite hydrogel;

[0062] (4) Dissolve azobisisobutyronitrile, styrene monomer and polyvinylpyrrolidone in a mixed solvent of ethanol and water, azobisisobutyronitrile, styrene monomer, polyvinylpyrrolidone, ethanol and water The mass ratio of the mixture is 0.2:6:1:60:25, stirred evenly and deoxygenated by ...

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Abstract

The invention discloses a preparation method of a pH-responsive photonic crystal gel base for skin wound treatment. The preparation method of the pH-responsive photonic crystal gel base for the skin wound treatment comprises the steps that chitosan, acrylic acid, N,N'-methylene bis acrylamide and Cu2WSe4 are used as raw materials, CS / PAA / nanoCu2WSe4 composite hydrogel is prepared by the photopolymerization method; a colloidal crystal template is prepared by the vertical deposition method; hydroxyethyl methacrylate and an acrylic acid monomer are mixed evenly with methanol, a photoinitiator canbe added, nitrogen is introduced to remove oxygen to obtain a precursor solution; the colloidal crystal template is immersed in the precursor solution, and the mixture reacts under ultraviolet lightirradiation to remove the template to obtain a membranous photonic crystal; the membranous photonic crystal is ultrasonically dispersed on the CS / PAA / nanoCu2WSe4 composite hydrogel, and the pH-responsive photonic crystal gel base is obtained. When preparation method of the pH-responsive photonic crystal gel base for the skin wound treatment is used for the treatment of skin wounds, the sterilization and treatment effects are good, and the infection and healing of the wound are easily observed and understood.

Description

technical field [0001] The invention relates to the field of antibacterial nanomaterials, in particular to a method for preparing a pH-responsive photonic crystal gel base for treating skin wounds. Background technique [0002] Hydrogel refers to a gel with water as the dispersion medium. A part of the hydrophobic group is introduced into the water-soluble polymer with a cross-linked structure to form a cross-linked polymer that can swell with water. It is a polymer network system with properties Soft, can hold a certain shape, can absorb a lot of water. All water-soluble or hydrophilic polymers can form hydrogels through certain chemical cross-linking or physical cross-linking. Hydrogels have good physicochemical properties and biocompatibility, which make them have many applications in the field of pharmacy. [0003] For example, a kind of "antibacterial and healing-promoting gel material for preparing medical wound dressing and its preparation method" disclosed in Chine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08F251/00C08F220/06C08F222/38C08F271/02C08F212/08C08F220/20C08F2/50C08F2/44C08K3/30
CPCA61L26/0023A61L26/0066A61L26/008A61L2300/102A61L2300/104A61L2300/404C08F2/44C08F2/50C08F251/00C08F271/02C08K3/30C08K2201/011C08L5/08C08F220/06C08F222/385C08F212/08C08F220/20
Inventor 周英棠
Owner ZHEJIANG OCEAN UNIV
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