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A preparation method of pH-responsive photonic crystal gel base for skin wound treatment

A photonic crystal, responsive technology, used in bandages, medical science, etc., can solve the problems of large load, inconvenient observation of wound healing and changes, and high cost

Active Publication Date: 2021-08-20
ZHEJIANG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention is to overcome the hydrogel with antibacterial effect loaded with nano-silver in the prior art, in order to have a good anti-bacterial effect, the required nano-silver loading is large or the dosage required for use is high, and the cost is relatively high; Moreover, when the hydrogel with antibacterial effect in the prior art is used for the treatment of skin wounds, the degree of infection of the wound cannot be directly observed, and it is not convenient to observe the healing and changes of the wound. A pH response for skin wound treatment is provided. The preparation method of type photonic crystal gel base, prepares CS / PAA / nanometer Cu 2 WS 4 Composite hydrogel and load pH-responsive photonic crystal matrix, the obtained pH-responsive photonic crystal gel matrix not only has good biological safety, but also can effectively treat wound infection and promote wound healing at a lower dose. ability; and because the wound infection is weakly acidic, the pH-responsive photonic crystal base can perform color reaction under Bragg diffraction, and the human eye can observe it naked

Method used

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  • A preparation method of pH-responsive photonic crystal gel base for skin wound treatment
  • A preparation method of pH-responsive photonic crystal gel base for skin wound treatment
  • A preparation method of pH-responsive photonic crystal gel base for skin wound treatment

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Experimental program
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Effect test

Embodiment 1

[0039] (1) Chitosan, acrylic acid, N,N′-methylenebisacrylamide and Cu with a mass ratio of 5:8:10:0.01 2 WS 4 Soluble in 1% acetic acid solution, after fully dissolved, deoxygenate with nitrogen for 30 minutes;

[0040] (2) Add 2,2-azobis(2-methylpropionamidine) dihydrochloride with a mass ratio of 1:30 to chitosan, seal it and put it under ultraviolet light to react, and the irradiation intensity is 400mW / cm 2 , the reaction time is 40min;

[0041] (3) Soak the obtained product in deionized water, change the water every 4 hours, repeat 10 times, and then cut the obtained product into 1cm 2 Small pieces of CS / PAA / nano-Cu were obtained after freeze-drying 2 WS 4 Composite hydrogel;

[0042] (4) Dissolve azobisisobutyronitrile, styrene monomer and polyvinylpyrrolidone in a mixed solvent of ethanol and water, azobisisobutyronitrile, styrene monomer, polyvinylpyrrolidone, ethanol and water The mass ratio of the mixture is 0.15:4:1:50:15, stirred evenly and deoxygenated by ...

Embodiment 2

[0049] (1) Chitosan, acrylic acid, N,N′-methylenebisacrylamide and Cu with a mass ratio of 15:9:12:0.05 2 WS 4 Soluble in 1.5% acetic acid solution, after fully dissolved, deoxygenate with nitrogen for 30 minutes;

[0050] (2) Add 2,2-azobis(2-methylpropionamidine) dihydrochloride with a mass ratio of 1:40 to chitosan, seal it and put it under ultraviolet light to react, the irradiation intensity is 450mW / cm 2 , the reaction time is 30min;

[0051] (3) Soak the obtained product in deionized water, change the water every 4.5h, repeat 15 times, and then cut the obtained product into 1cm 2 Small pieces of CS / PAA / nano-Cu were obtained after freeze-drying 2 WS 4 Composite hydrogel;

[0052] (4) Dissolve azobisisobutyronitrile, styrene monomer and polyvinylpyrrolidone in a mixed solvent of ethanol and water, azobisisobutyronitrile, styrene monomer, polyvinylpyrrolidone, ethanol and water The mass ratio of the mixture is 0.17:5:1:55:20, stirred evenly and deoxygenated by nitr...

Embodiment 3

[0059] (1) Chitosan, acrylic acid, N,N′-methylenebisacrylamide and Cu with a mass ratio of 25:10:15:0.1 2 WS 4 Soluble in 2% acetic acid solution, after fully dissolved, deoxygenate with nitrogen for 30 minutes;

[0060] (2) Add 2,2-azobis(2-methylpropionamidine) dihydrochloride with a mass ratio of 1:50 to chitosan, seal it and put it under ultraviolet light to react, and the irradiation intensity is 500mW / cm 2 , the reaction time is 20min;

[0061] (3) Soak the obtained product in deionized water, change the water every 5 hours, repeat 20 times, and then cut the obtained product into 1cm 2 Small pieces of CS / PAA / nano-Cu were obtained after freeze-drying 2 WS 4 Composite hydrogel;

[0062] (4) Dissolve azobisisobutyronitrile, styrene monomer and polyvinylpyrrolidone in a mixed solvent of ethanol and water, azobisisobutyronitrile, styrene monomer, polyvinylpyrrolidone, ethanol and water The mass ratio of the mixture is 0.2:6:1:60:25, stirred evenly and deoxygenated by ...

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Abstract

The invention discloses a preparation method of a pH-responsive photonic crystal gel base for treating skin wounds. 2 WS 4 As raw material, CS / PAA / nano-Cu was prepared by photopolymerization 2 WS 4 Composite hydrogel; using the vertical deposition method to prepare colloidal crystal templates; mixing hydroxyethyl methacrylate and acrylic acid monomers with methanol, adding photoinitiators, and deoxidizing with nitrogen to obtain a precursor solution; immersing the colloidal crystal templates in In the precursor solution, the film-like photonic crystal was obtained after removing the template under ultraviolet light irradiation; the film-like photonic crystal was ultrasonically dispersed in CS / PAA / nano-Cu 2 WS 4 On the composite hydrogel, a pH-responsive photonic crystal gel base is obtained. When the invention is used for the treatment of skin wounds, the sterilization and treatment effects are good, and it is convenient to observe and understand the infection and healing conditions of the wounds.

Description

technical field [0001] The invention relates to the field of antibacterial nanomaterials, in particular to a method for preparing a pH-responsive photonic crystal gel base for treating skin wounds. Background technique [0002] Hydrogel refers to a gel with water as the dispersion medium. A part of the hydrophobic group is introduced into the water-soluble polymer with a cross-linked structure to form a cross-linked polymer that can swell with water. It is a polymer network system with properties Soft, can hold a certain shape, can absorb a lot of water. All water-soluble or hydrophilic polymers can form hydrogels through certain chemical cross-linking or physical cross-linking. Hydrogels have good physicochemical properties and biocompatibility, which make them have many applications in the field of pharmacy. [0003] For example, a kind of "antibacterial and healing-promoting gel material for preparing medical wound dressing and its preparation method" disclosed in Chine...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08F251/00C08F220/06C08F222/38C08F271/02C08F212/08C08F220/20C08F2/50C08F2/44C08K3/30
CPCA61L26/0023A61L26/0066A61L26/008A61L2300/102A61L2300/104A61L2300/404C08F2/44C08F2/50C08F251/00C08F271/02C08K3/30C08K2201/011C08L5/08C08F220/06C08F222/385C08F212/08C08F220/20
Inventor 周英棠
Owner ZHEJIANG OCEAN UNIV