Instant puncture dialysis type nanofiber artificial blood vessel

Abstract

The invention provides an instant puncture dialysis type nanofiber artificial blood vessel. The vessel wall of the instant puncture dialysis type artificial blood vessel is provided with an inner layer, an outer layer and a non-porous dense coating located between the inner layer and the outer layer, wherein the inner layer is of an electrostatic spinning nanofiber structure; a layer of anticoagulant coating is fixed on the inner wall of the inner layer; the outer layer is of the electrostatic spinning nanofiber structure; an anti-bending ring is wrapped in the non-porous dense coating; the anti-bending ring is a spiral winding wire with a spiral structure; and the spiral winding wire is spirally wound around the inner layer. The invention also provides a preparation method of the artificial blood vessel. The inner wall and the outer wall of the artificial blood vessel are nanofibers, so that the structure of a natural extracellular matrix can be sufficiently simulated, a good environment is provided for growth, adhesion and migration of cells, and the relatively high porosity is beneficial to the exchange of nutrient substances; and the dense layer has relatively high elasticity,and the position of a puncture hole can be automatically healed, so that the leakage of blood is prevented, and the hemostasis time is shortened.

Description

technical field [0001] The invention relates to the field of biomedical devices, in particular to the application of an instant puncture dialysis nanofiber artificial blood vessel in dialysis fistula. Background technique [0002] A common problem with vascular grafts is bleeding through the small holes punctured into the graft wall by suture needles or dialysis needles. Commercially available vascular grafts are usually made of polyethylene terephthalate fabric or expanded polytetrafluoroethylene tubing, and materials of biological origin, such as human autologous saphenous vein vessels, have also been used. The needles used to staple these vascular grafts often cause profuse bleeding from the perforation before the surgical incision is closed. Dialysis treatment for people with kidney failure involves pumping the patient's blood, circulating it through a dialysis machine, and returning it to the patient. A common method of providing the necessary hemodialysis access is a...

AI Technical Summary

Problems solved by technology

[0005] A three-layer ePTFE artificial blood vessel is used for early clinical dialysis vascular access. The middle silicone layer of the three-layer structure can provide rapid closure of the puncture hole. The inner layer of the vascular graft is traditional ePTFE material, and the middle layer is soft Elastic silicone, the outer layer is made of ePTFE material, and the silicone layer is used as the closing layer. When a suture needle or a dialysis needle is punctured, it can rebound quickly, making up for the lack of resilience of the ePTFE material, thereby reducing blood leakage. The artificial blood vessel is open In the U.S. patent Wayne et al. in the patent US2006 / 0118236A1, but this multi-layer structure causes the outer diameter of the graft vessel to be thicker and the compliance is reduced, and when the artificial blood vessel is matched with the autologous blood vessel trimming, it is necessary to avoid the exposure of the middle silica gel layer and Blood contact forms acute thrombus, which increases the difficulty in clinical use

Similarly, in the Chinese patent CN208974736U, the ePTFE artificial blood vessel with three-layer structure is coated with silk fibroin on the inner layer, but its anticoagulant effect is much lower than that of heparin, and it cannot provide good anticoagulant properties between vascular endothelialization

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