Oral nano iron supplement and preparation method thereof

An iron supplement and nano-iron technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and digestive systems, etc., can solve the problems of increasing infection efficiency, gastrointestinal discomfort, poor absorption, etc., and achieve high magnetic response performance, The effect of low side effects and good application potential

Inactive Publication Date: 2020-01-14
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral iron supplements also have many defects: for example, ferrous iron can cause strong gastrointestinal discomfort, increase the infection rate of the whole body, induce changes in the commensal flora of the colon, and increase the inflammatory factor signals of intestinal epithelial cells; The iron-valent form is

Method used

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  • Oral nano iron supplement and preparation method thereof
  • Oral nano iron supplement and preparation method thereof
  • Oral nano iron supplement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Dissolve sodium carboxymethyl cellulose (500 mg, viscosity 50-100 mPa·S, carboxyl substitution degree 0.9) in hot water (200 mL), stir well for 1 h until a uniform and transparent solution is formed; when the solution is room temperature, add 1 mL of 6N hydrochloric acid aqueous solution, under the blowing of nitrogen gas, mix the iron salt solution (3 g of ferric salt and 1.5 g of ferrous salt in water to form a solution, 50 mL) and cellulose solution; place the reaction system in an alternating magnetic field In the center of the generating coil, inject concentrated ammonia solution (30 mL) at high temperature; turn on the alternating magnetic field to control various operating parameters of the magnetic field. Maintain the temperature, stir at high speed for 40 minutes, and keep nitrogen blowing during the period; turn off the magnetic field, wait for the reaction solution to cool down to room temperature, centrifuge to remove the precipitated aggregates at the bottom...

Embodiment 2

[0042] Dissolve hydroxypropyl methylcellulose (100 mg, viscosity 50 mPa·S) in hot water (150 mL), stir well for 2 h until a uniform and transparent solution is formed; when the solution is at room temperature, add 1 mL of 6N hydrochloric acid aqueous solution dropwise, and Mix the iron salt solution (2 g of ferric salt and 1 g of ferrous salt in water to form a solution, 40 mL) and the cellulose solution; place the reaction system in the center of the alternating magnetic field generation coil and inject it at high temperature Concentrated ammonia solution (10 mL); turn on the alternating magnetic field, control various operating parameters of the magnetic field, the output frequency of the alternating magnetic field is 390 kHz-1.5 GHz, rapidly heat the solution to 70-80 °C, maintain the temperature, stir at high speed for 50 Minutes, during which the nitrogen gas has been kept blowing; turn off the magnetic field, wait for the reaction solution to cool down to room temperature, ...

Embodiment 3

[0044] The oral nano-iron supplements prepared in Example 1 and Example 2 were tested for structural composition and other related properties: including overall particle size and Zeta potential (particle size potential analyzer), iron core size (transmission electron microscope), oxidation Iron structure (X-ray diffractometer), cellulose content (thermogravimetric analyzer), magnetic response capability (vibrating sample magnetometer), gastric acid solubility (in vitro simulated gastric acid environment test), test results see Figure 1-Figure 8 .

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Abstract

The invention discloses an oral nano iron supplement and a preparation method thereof, and effect of the oral nano iron supplement on intestinal flora of rats. The oral nano iron supplement is formedby wrapping iron oxide crystals with a pharmaceutical excipient cellulose. The cellulose comprises sodium carboxymethylcellulose, calcium carboxymethylcellulose, croscarmellose sodium, hydroxy propylcellulose, hydroxypropyl methyl cellulose or cellulose acetate. The iron supplement is used in a rat model with iron-deficiency anemia, can supplement hemoglobin to complete treatment of anemia in 3 weeks, and has higher curative effect and lower side effect than a traditional oral chalybeate ferrous sulfate. Through high-throughput sequencing for intestinal flora of rats, the anaylysis of 16S rRNA shows that the oral iron supplement of the invention can significantly increase abundance and diversity of intestinal flora of rats, promote to restore a steady state of the intestinal flora, facilitate normal growth of the rats and has great application potential in a human body compared to an iron-deficient group and an iron-supplementing group with ferrous sulfate.

Description

technical field [0001] The present invention relates to an oral nano-iron supplement and its preparation method, and its effect on the intestinal flora of rats, in particular to iron oxide coated with cellulose as a pharmaceutical auxiliary material, and its effect on the intestinal flora of rats. beneficial effect. Background technique [0002] Iron-deficiency anemia is a worldwide disease caused by insufficient supply of iron in the body or metabolic problems that lead to reduction of red blood cells. The current clinical treatment methods include iron fortification therapy, oral iron supplementation and intravenous iron supplementation, etc. Most of the existing oral iron supplementation uses some bioactive molecules (protein succinic acid, fumaric acid, citric acid, etc.) to encapsulate the structure Prepared from less stable iron hydroxides (ferric hydroxide, ferrous hydroxide, etc.). Due to the ease of operation and high compliance to patients, oral iron supplementat...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K33/26A61K47/38A61P3/02A61P7/06A61P1/00
CPCA61K9/5161A61K33/26A61P1/00A61P3/02A61P7/06
Inventor 顾宁陈博赵鹏郭占航王琪炜
Owner SOUTHEAST UNIV
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