Preparation method for toothpaste capable of repairing dental enamel

A tooth enamel and toothpaste technology, applied in daily chemical products and medical fields, can solve the problems of low remineralization rate, low concentration of free calcium ions and phosphate ions

Active Publication Date: 2020-05-12
YUNNAN BAIYAO GRP HEALTH PROD CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, directly adding calcium salts and phosphates to toothpaste, toothpaste can provide a lower concentration of free calcium ions and phosphate ions, and the rate of remineralization on tooth enamel is smaller when brushing time and frequency are limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1) Preparation of water-in-oil-in-water emulsion containing soluble calcium salt

[0025] Add 0.02 g of sucrose fatty acid ester into 100 g of rapeseed oil, heat to 30° C. and stir evenly to obtain an oil phase. Then 0.5 milliliters of 0.1% calcium chloride solution and 9.5 milliliters of rapeseed oil containing sucrose fatty acid esters were heated to 80° C. for mixing, and stirred with a high-speed disperser at a speed of 300 rpm for 120 minutes to obtain a water-in-oil emulsion .

[0026] The aqueous phase was prepared by adding 5 grams of sodium lauryl sulfate to 100 grams of water. 0.5 ml of the prepared water-in-oil emulsion and 9.5 ml of water phase were heated to 30° C. for mixing, and stirred with a high-speed disperser at a speed of 24,000 rpm for 0.5 minutes to obtain a water-in-oil-in-water emulsion containing soluble calcium salts.

[0027] 2) Preparation of a water-in-oil-in-water emulsion containing soluble phosphate.

[0028] Add 5 grams of sucrose fa...

Embodiment 2

[0034]This example is the same as Example 1, except that the surfactant (other surfactants except Example 1) used when preparing the water-in-oil emulsion is Span60, Span65, glyceryl stearate, dehydration Sorbitan monostearate, sorbitan monopalmitate, sodium stearoyl lactylate, calcium stearoyl lactylate, rosin glyceride, sucrose acetate, sucrose isobutyrate, Span80, polyoxyethylene xylitol Monostearate, Hydrogenated Rosin Glyceride, Diacetyl Tartaric Acid Mono- and Diglyceride, Propylene Glycol Fatty Acid Ester, Dipolyglycerol Monostearate, Monoglyceride, Triglyceride, Propylene Glycol Fatty Acid Ester, Soy Lecithin , one of monoglyceride laurate, or sucrose fatty acid ester, Span60, Span65, glyceryl stearate, sorbitan monostearate, sorbitan monopalmitate, sodium stearoyl lactylate , calcium stearoyl lactylate, rosin glyceride, sucrose acetate, sucrose isobutyrate, Span80, polyoxyethylene anhydroxylitol monostearate, hydrogenated rosin glyceride, diacetyl tartaric acid mono- ...

Embodiment 3

[0037] 1) Prepare a water-in-oil-in-water emulsion containing soluble calcium salts.

[0038] Add 0.1 g of glycerol stearate into 2 g of sunflower oil, heat to 80° C. and stir evenly to obtain an oil phase. Then 1.5 milliliters of 60% calcium nitrate solution and 1 milliliter of sunflower oil containing glyceryl stearate were heated to 30° C. for mixing, and stirred with a high-speed disperser at a speed of 24,000 rpm for 0.5 minutes to obtain a water-in-oil emulsion .

[0039] Add 1 gram of sodium caseinate to 4 grams of water, and stir evenly to obtain an aqueous phase. 1.5 ml of the prepared water-in-oil emulsion and 1 ml of water phase were heated to 80° C. for mixing, and dispersed at a speed of 300 rpm for 120 minutes with a high-speed disperser to obtain a water-in-oil-in-water emulsion containing calcium ions.

[0040] 2) Preparation of a water-in-oil-in-water emulsion containing soluble phosphate.

[0041] Add 0.5 g of glyceryl stearate into 2 g of sunflower oil, h...

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PUM

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Abstract

The invention relates to a preparation method for toothpaste capable of repairing dental enamel. According to the preparation method, soluble calcium salt and soluble phosphate are each wrapped with an inner water phase of a water-in-oil-in-water emulsion, and thus, after being added into the toothpaste, the soluble calcium salt and soluble phosphate can stably exist at the same time for a long time without reacting to produce calcium phosphate precipitates. When teeth are brushed with the toothpaste, the water-in-oil-in-water emulsion breaks up under the action of friction and extrusion to release the soluble calcium salt and / or the soluble phosphate wrapped in the inner water phases, so that liquid in an oral cavity contains calcium ions and phosphate anions of relatively high concentration, and the remineralization rate of the dental enamel and dentin in the oral cavity can be increased.

Description

technical field [0001] The invention belongs to the technical field of medical treatment and daily chemical products, and in particular relates to a tooth composition (dentin, enamel) mineralization (bionic mineralization, remineralization) restoration, that is, a preparation method of a toothpaste capable of repairing tooth enamel. Background technique [0002] Tooth enamel is the hardest tissue in the human body. As the outermost layer of teeth, enamel is subjected to various physical and chemical erosions, such as occlusal, friction, abrasion, and acid erosion from diet and bacteria. Hydroxyapatite dissolves to produce enamel when pH<5.5 demineralization problem. [0003] Saliva contains calcium ions and phosphate ions, which to a certain extent buffer the changes in the pH value of saliva, thereby inhibiting the dissolution of hydroxyapatite. When the pH>5.5 and the concentration of calcium ions and phosphorus ions are high, calcium phosphate is produced in saliv...

Claims

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Application Information

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IPC IPC(8): A61K8/06A61K8/19A61K8/24A61K8/365A61Q11/00A61P1/02
CPCA61K8/06A61K8/19A61K8/24A61K8/365A61Q11/00A61P1/02A61K8/066A61K8/375A61K8/92A61K2800/5922A61K2800/805B01F23/41B01F23/49B01F23/48B01F23/4144
Inventor 宁科功贺拥军
Owner YUNNAN BAIYAO GRP HEALTH PROD CO LTD
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