Medical bleeding stopping dressing, preparation method and application of preparation method

A technology of hemostatic dressings and raw materials, applied in medical formula, medical science, bandages, etc., can solve the problems of increasing pain and economic burden of patients, secondary injury of wounds, and large loss of drugs, so as to reduce the chance of wound infection and improve Biocompatibility, effect of reducing labor intensity

Active Publication Date: 2020-07-31
SHAANXI GIANT BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional medical hemostatic gauze is not very thorough in cleaning the wound when treating the wound, and has little auxiliary effect on wound healing
In addition, when treating wounds, cleaning the wound surface is very important. Many hemostatic dressings currently on the market have poor hygroscopicity and cannot clean residual blood and foreign matter on the wound surface. They need to be used many times, which may cause secondary damage to the wou

Method used

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  • Medical bleeding stopping dressing, preparation method and application of preparation method
  • Medical bleeding stopping dressing, preparation method and application of preparation method
  • Medical bleeding stopping dressing, preparation method and application of preparation method

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preparation example Construction

[0055] The invention provides a kind of preparation method of medical hemostatic dressing, it comprises the steps:

[0056] Dissolving the recombinant collagen to obtain A solution;

[0057] Dissolving the water-soluble high molecular polymer and the moisture retaining agent into the solution to obtain the B solution;

[0058] A solution, B solution, an optional stabilizer and an optional plasticizer are mixed to obtain a first mixed solution;

[0059] The first mixed solution is frozen, then soaked, washed, centrifuged and sterilized, wherein, in parts by weight, the medical hemostatic dressing contains 0.5-2 parts of recombinant collagen, 1-5 parts of water-soluble polymer substance and 0.2-1 part of moisture retaining agent.

[0060] Wherein, "optionally" means that the raw material may or may not be added.

[0061] In a preferred embodiment of the present invention, wherein the method comprises the following steps:

[0062] Dissolving the recombinant collagen to form A...

Embodiment 1

[0082] The preparation of embodiment 1 medical hemostatic dressing

[0083] (1) Dissolve 1 g of recombinant collagen in 20 mL of distilled water at room temperature to form A solution;

[0084] (2) Dissolve 2g of polyvinyl alcohol and 0.5g of sodium carboxymethylcellulose in 28.5mL of distilled water in a water bath at 80°C to form solution B;

[0085] (3) Mix 20mL of LA solution, 28.5mL of B solution, 1.26g of glycerol, and 0.53g of polysorbate 80 in a 60°C water bath, take it out of the water bath and immediately pour it into an aluminum mold to obtain the first mixed solution.

[0086] (4) Freeze the first mixed solution in a -20°C refrigerator for 24 hours, take it out and place it at room temperature for 3 hours to fully thaw, repeat the freezing-thawing process 3 times, and obtain the second mixed solution;

[0087] (5) Soak the second mixed solution in purified water for 2 hours, then wash it in an ultrasonic cleaning machine for 3 times, each time for 10 minutes to ob...

Embodiment 2

[0089] The preparation of embodiment 2 medical hemostatic dressings

[0090] (1) Dissolve 2g of recombinant collagen in 20mL of distilled water at room temperature to form A solution;

[0091] (2) Dissolve 1g of sodium hyaluronate and 0.5g of sodium carboxymethylcellulose in 29mL of distilled water in a water bath at 80°C to form solution B;

[0092] (3) Fully mix 20mL of LA solution, 29mL of BB solution, 0.8g of butyryl tri-n-hexyl citrate, and 0.9g of epoxidized soybean oil in a 60°C water bath, take it out of the water bath and immediately pour it into an aluminum mold to obtain the first mixture solution;

[0093] (4) The first mixed solution was frozen in a -20°C refrigerator for 24 hours, then taken out and placed at room temperature for 3 hours to fully thaw, and the freezing-thawing process was repeated 3 times to obtain the second mixed solution;

[0094] (5) Soak the second mixed solution in purified water for 3 hours, then wash it in an ultrasonic cleaning machine...

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Abstract

The invention discloses a medical bleeding stopping dressing, a preparation method and an application of the preparation method. The medical bleeding stopping dressing provided by the invention comprises the following raw materials in parts by weight of 0.5-2 parts of recombinant collagen, 1-5 parts of a water soluble polymer, and 0.2-1 part of a water retention agent. The medical bleeding stopping dressing provided by the invention has high water absorption and blood absorption properties, the moisture absorption multiplying power is 50-300 times of self weight of the medical bleeding stopping dressing, wound liquid can be effectively eliminated, and the medical bleeding stopping dressing has obvious bleeding stopping effects on bleeding wounds. The water retention agent and the water soluble polymer are added, so that the dressing is soft and smooth in surface and free from adhesion, and secondary damage of the wounds in the bleeding stopping and wound cleaning process can be avoided. In addition, the raw materials are the recombinant collagen, medicine carrying capacity is high, the effect of healing wounds is obvious, and the medical bleeding stopping dressing is widely applied, can be used for surgical hemostasis high in bleeding amount and elimination and treatment of common wounds, and is suitable for wounds of various stages.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a medical hemostatic dressing, a preparation method and an application thereof. Background technique [0002] Trauma is currently one of the leading causes of death in the world. Because trauma patients are mostly young people, it places a huge burden on society. At present, the more commonly used hemostatic dressings mainly include gelatin sponge, oxidized cellulose, fibrin glue, collagen sponge, etc., but they all have certain defects more or less. For example, gelatin sponge and collagen sponge both achieve the purpose of hemostasis by aggregating a large number of platelets and coagulation factors, and their water absorption capacity is poor, which greatly limits their application range. Fibrin glue is mainly prepared from blood plasma, so it is more likely to be infected with viruses during use. Traditional medical hemostatic gauze does not clean the wound th...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/24A61L15/26A61L15/28A61L15/20A61L15/18A61L15/40A61L15/42A61L15/44A61L15/46A61L15/50A61L15/64
CPCA61L15/325A61L15/24A61L15/26A61L15/28A61L15/20A61L15/18A61L15/40A61L15/42A61L15/44A61L15/46A61L15/50A61L15/64A61L2400/04A61L2300/404A61L2300/412A61L2300/30C08L29/04C08L1/286C08L1/284C08L5/08C08L67/04
Inventor 范代娣康华平段志广马晓轩
Owner SHAANXI GIANT BIOTECHNOLOGY CO LTD
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