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Modified polyvinyl chloride and preparation method thereof, irradiation-resistant sterilization venous indwelling needle connecting hose and indwelling needle

A technology of polyvinyl chloride and connecting hoses, which is applied in the field of medical materials, can solve the problems of large color yellowing and large pH changes of products, achieve the effect of no aluminum precipitation and improve radiation resistance

Active Publication Date: 2020-08-07
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The modified polyvinyl chloride provided by the invention can effectively improve the radiation resistance of intravenous indwelling needles, overcome the problems of large pH changes and large yellowing of the product after irradiation sterilization, and has no aluminum dissolution

Method used

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  • Modified polyvinyl chloride and preparation method thereof, irradiation-resistant sterilization venous indwelling needle connecting hose and indwelling needle
  • Modified polyvinyl chloride and preparation method thereof, irradiation-resistant sterilization venous indwelling needle connecting hose and indwelling needle
  • Modified polyvinyl chloride and preparation method thereof, irradiation-resistant sterilization venous indwelling needle connecting hose and indwelling needle

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0062] The present invention also provides a method for preparing the modified polyvinyl chloride described in the above technical solution, comprising:

[0063]Polyvinyl chloride, main plasticizer, epoxy vegetable oil, calcium soap, zinc soap, hindered amine, phosphite, amorphous calcium silicate and auxiliary stabilizer are melt-extruded and pelletized to obtain modified polyvinyl chloride pellets .

[0064] Wherein, the types, dosages and sources of the above-mentioned various raw materials are consistent with those described in the above-mentioned technical solutions, and will not be repeated here.

[0065] In the present invention, it is preferable to mix the above-mentioned various materials in a high-speed mixer first, stop mixing when the temperature rises to 110-135°C, and then cool to below 60°C to obtain dry powder. Afterwards, the obtained dry powder is melt-extruded and granulated. Wherein, the melt extrusion can be carried out by means of a twin-screw extruder....

Embodiment 1

[0073] According to the silicon:calcium molar ratio of 1:1, weigh 1422.0g sodium metasilicate nonahydrate and calcium nitrate tetrahydrate 1180.8g respectively, and dissolve them in 10L distilled water respectively to obtain calcium nitrate solution and sodium metasilicate nonahydrate solution. Under high-speed stirring (400rpm), the obtained calcium nitrate solution was slowly added dropwise to the sodium metasilicate nonahydrate solution. After the dropwise addition, the stirring reaction was continued for 4h (the whole process was carried out at room temperature at 20±5°C), and then at room temperature. Aging for 6 hours, centrifuged and washed three times with distilled water, dried at 110°C, crushed through a 1000-mesh sieve to obtain amorphous calcium silicate (Si / Ca=1:1).

[0074] On the basis of the above preparation method, the ratio of raw materials was adjusted to prepare amorphous calcium silicate with other Si / Ca ratios, which were used in subsequent examples and c...

Embodiment 2

[0076] 1.1 Raw material

[0077]

[0078] 1.2 Preparation

[0079] S1. Put the above-mentioned raw materials into a high-speed mixer, stop mixing when the temperature rises to 130°C, and discharge the materials into a cooler to cool below 60°C to obtain a dry powder.

[0080] S2. The dry powder is granulated through a conical twin-screw extruder, and the extrusion temperature is set to be 160°C, 170°C, 175°C, 175°C, 175°C, 165°C, and 155°C in sequence from the feed port to the die , to obtain radiation-resistant modified PVC pellets after melt extrusion.

[0081] S3. The obtained modified PVC granules are prepared into a connecting hose with an outer diameter of 2.05±0.05mm and an inner diameter of 1.00±0.05mm through a pipe drawing machine.

[0082] Use the above connecting hoses in accordance with figure 1 Assemble the IV catheter. See Table 1 for relevant test results such as pH value, yellowness index, and aluminum content of water soluble matter after irradiation s...

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Abstract

The invention provides modified polyvinyl chloride and a preparation method thereof, an irradiation-resistant sterilization venous indwelling needle connecting hose and an indwelling needle. Polyvinylchloride is used as a matrix; amorphous calcium silicate is used as an acid absorbent; triazinyl hindered amine is adopted and matched with calcium soap, zinc soap, phosphite ester, a plasticizer, epoxy vegetable oil and an auxiliary stabilizer according to a certain proportion, under the combined action of the components, the irradiation resistance of the venous indwelling needle can be improved, and the problems that after irradiation sterilization, the pH change of a product is large, and color yellowing is large are solved. And meanwhile, the venous indwelling needle can be ensured not tobe dissolved out by aluminum.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a modified polyvinyl chloride and a preparation method thereof, a radiation-resistant sterilization intravenous indwelling needle connecting hose and an indwelling needle. Background technique [0002] Venous indwelling needles can greatly reduce the workload of venipuncture for nursing staff and reduce the pain of repeated venipuncture for patients. It has become a medical device widely used by inpatients. At present, intravenous indwelling needles are generally sterilized with ethylene oxide. The advantage of ethylene oxide sterilization is that the temperature condition is relatively mild, and it will not or only cause a small loss in the performance of polymer materials. However, the intravenous indwelling needle is structurally a mechanically sealed medical device (its structure is as follows: figure 1 As shown), after ethylene oxide sterilization, there is a prob...

Claims

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Application Information

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IPC IPC(8): C08L27/06C08L91/00C08K13/02C08K5/12C08K5/098C08K3/34A61M5/158A61M39/10
CPCA61M5/158A61M39/10A61M2005/1587C08K2201/014C08L27/06C08L2201/08C08L91/00C08K13/02C08K5/12C08K5/098C08K3/34
Inventor 杨华伟栾世方孙振龙殷敬华石恒冲闫顺杰张德海黄尉
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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