Clostridium butyricum and application of clostridium butyricum in immobilized fermentation production of 1, 3-propylene glycol

An immobilized fermentation, Clostridium butyricum technology, applied in fermentation, microorganism-based methods, bacteria, etc., can solve the problems of obvious inhibition, low substrate glycerol tolerance, low production intensity, etc.
CN112358986AActive Publication Date: 2021-02-12SOUTH CHINA UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Publication Date
2021-02-12

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Abstract

The invention discloses clostridium butyricum and an application thereof in immobilized fermentation production of 1, 3-propylene glycol, the clostridium butyricum is clostridium butyricum SCUT343-4 and is preserved in Guangdong province microbial strain preservation center on October 12, 2019, and the preservation number is GDMCC NO: 60805. The strain can be used for directly converting pure glycerol or crude glycerol into 1, 3-propylene glycol, has higher substrate conversion rate and substrate tolerance, has few types and contents of byproducts, and is beneficial to separation and purification of subsequent products; the strain has the most outstanding tolerance to a substrate crude glycerol, and the conversion rate and the production efficiency are not reduced during crude glycerol fermentation, so that the processing and utilization of the crude glycerol are facilitated, and the production cost of the 1, 3-propylene glycol is remarkably reduced. The strain is applied to immobilized fermentation production of 1, 3-propylene glycol, the production efficiency can be remarkably improved and reaches 4.20 g / L.h.
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Description

technical field

[0001] The invention belongs to the technical field of bioengineering fermentation, and in particular relates to a high-yield 1,3-propanediol Clostridium butyricum and an immobilized fermentation method. Background technique

[0002] 1,3-propanediol (1,3-propanediol), the molecular formula is C 3 h 8 o 2 As an important chemical raw material, it is widely used in many industries such as pharmaceuticals, food, cosmetics and textiles. At present, chemical synthesis is mostly used in industrial production, and the mature routes are (1) DuPont: acrolein route, that is, acrolein is converted into 3-hydroxypropionaldehyde (3-HPA) through hydration, and then hydrogenated to generate 1,3 -Propylene glycol; (2) Royal Shell Petroleum Company: Ethylene oxide route, that is, ethylene oxide hydroformylation method to prepare 3-hydroxypropionaldehyde, and then hydrogenation to generate 1,3-propanediol. However, the above two chemical pathways are not only technically d...

Claims

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