Super-hydrophobic multifunctional coating with sequential drug release function and preparation method of super-hydrophobic multifunctional coating

Abstract

The invention discloses a super-hydrophobic multifunctional coating with a sequential drug release function and a preparation method thereof. The preparation method comprises the following steps that S1, a substrate material is polished, cleaned and dried, then the substrate material is placed in an acidic buffer solution, dopamine, a drug for promoting endothelial cell growth and an oxidizing agent are added, a reaction is performed for 1-50 h in the environment of 10-40 DEG C, cleaning is performed, and the substrate material containing composite nanoparticles on the surface is obtained; S2, a functional drug and 1H,1H,2H,2H-perfluorododecyl mercaptan are diluted by using a mixed solvent of water and a water-soluble organic solvent, and a drug / fluoride mixed diluent is obtained; and S3, the substrate material containing the composite nanoparticles on the surface obtained in S1 is immersed in the drug / fluoride mixed diluent obtained in S2, ultraviolet radiation is performed for 0.1-5 h, cleaning and nitrogen drying are performed, and the super-hydrophobic multifunctional coating is obtained. The preparation method is simple, mild in reaction condition, good in repeatability, low in cost and convenient to popularize and use, and the prepared coating material can release drugs in a sequential manner according to service environment requirements.

Description

technical field

[0001] The invention belongs to the technical field of biomedical functional materials, in particular to a superhydrophobic multifunctional coating with sequential drug release and a preparation method thereof. Background technique

[0002] Once blood-contact materials come into contact with blood, the proteins in the blood, especially fibrinogen, will adhere and denature on the surface of the material in a short period of time to form fibrin, which makes platelets adhere, activate and aggregate, followed by more Fibrinogen denaturation and platelet adhesion, activation and aggregation, and red blood cell network, and finally the acute formation of thrombus. At the same time, the non-specific adhesion of the protein on the surface of the material allows the body to be recognized by the macrophages of the immune system. When the macrophages cannot swallow foreign matter, they form giant cells through self-fusion and secrete cytokines (peak within 24 hours). ,...

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