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Super-hydrophobic multifunctional coating with sequential drug release function and preparation method of super-hydrophobic multifunctional coating

A multi-functional coating and super-hydrophobic technology, applied in coatings, drug delivery, pharmaceutical formulations, etc., can solve problems such as the difficulty in further constructing super-hydrophobic synergistic slow-release drug coatings, unstable super-hydrophobic surface structures, etc., and achieve excellent Biological function, promotion of endothelial cell growth, broad-spectrum practical effect

Active Publication Date: 2021-06-15
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a superhydrophobic multifunctional coating with sequential drug release and its Preparation

Method used

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  • Super-hydrophobic multifunctional coating with sequential drug release function and preparation method of super-hydrophobic multifunctional coating
  • Super-hydrophobic multifunctional coating with sequential drug release function and preparation method of super-hydrophobic multifunctional coating

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Embodiment 1

[0047] A preferred embodiment of the present invention provides a method for preparing a superhydrophobic multifunctional coating with sequential drug release, the specific steps are as follows:

[0048] (1) Pretreatment of polishing, cleaning and drying the base material polyurethane;

[0049] (2) putting the pretreated polyurethane of step (1) into the disodium hydrogen phosphate-citric acid buffer solution with pH of 3, and adding dopamine, eporselen and 30% hydrogen peroxide, so that dopamine, eporselen and The final concentration of 30% hydrogen peroxide is 1mg / mL, 0.5mg / mL and 0.5mg / mL respectively, then react at 15°C for 2h, wash and set aside;

[0050] (3) Dilute magnolol and 1H,1H,2H,2H-perfluorododecanethiol with a mixture of water and methanol, wherein the volume ratio of water and methanol is 1:3, and the final concentration of magnolol is 0.5mg / mL, the final concentration of 1H,1H,2H,2H-perfluorododecanethiol is 1mg / mL;

[0051] (4) Submerge the polyurethane co...

Embodiment 2

[0053] A preferred embodiment of the present invention provides a method for preparing a superhydrophobic multifunctional coating with sequential drug release, the specific steps are as follows:

[0054] (1) Pretreatment of polishing, cleaning and drying the base material titanium alloy;

[0055] (2) putting the titanium alloy pretreated in step (1) into the citric acid-sodium hydroxide-hydrochloric acid buffer solution with a pH of 3.5, and adding dopamine, copper ions and potassium permanganate, so that dopamine, copper ions and permanganate The final concentration of ammonium sulfate is 2mg / mL, 1mg / mL and 2mg / mL respectively, then react at 20°C for 4h, wash and set aside;

[0056] (3) Dilute honokiol and 1H,1H,2H,2H-perfluorododecanethiol with a mixture of water and ethanol, wherein the volume ratio of water and ethanol is 1:4, and the final concentration of magnolol is 1mg / mL, the final concentration of 1H,1H,2H,2H-perfluorododecanethiol is 2mg / mL;

[0057] (4) Submerge...

Embodiment 3

[0059] A preferred embodiment of the present invention provides a method for preparing a superhydrophobic multifunctional coating with sequential drug release, the specific steps are as follows:

[0060] (1) Carry out the pretreatment of polishing, cleaning and drying to the base material polylactic acid;

[0061] (2) Put the polylactic acid pretreated in step (1) into the citric acid-sodium hydroxide-hydrochloric acid buffer solution with a pH of 4, and add dopamine, selenocystamine and ammonium persulfate to make dopamine, selenocystamine The final concentrations of amine and potassium permanganate are 4mg / mL, 2mg / mL and 3mg / mL respectively, then react at 20°C for 5h, wash and set aside;

[0062] (3) Dilute magnoloaldehyde B and 1H, 1H, 2H, 2H-perfluorododecanethiol with a mixture of water and isopropanol, wherein the volume ratio of water and isopropanol is 1:9, and magnoloaldehyde The final concentration of B is 2mg / mL, and the final concentration of 1H,1H,2H,2H-perfluoro...

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Abstract

The invention discloses a super-hydrophobic multifunctional coating with a sequential drug release function and a preparation method thereof. The preparation method comprises the following steps that S1, a substrate material is polished, cleaned and dried, then the substrate material is placed in an acidic buffer solution, dopamine, a drug for promoting endothelial cell growth and an oxidizing agent are added, a reaction is performed for 1-50 h in the environment of 10-40 DEG C, cleaning is performed, and the substrate material containing composite nanoparticles on the surface is obtained; S2, a functional drug and 1H,1H,2H,2H-perfluorododecyl mercaptan are diluted by using a mixed solvent of water and a water-soluble organic solvent, and a drug / fluoride mixed diluent is obtained; and S3, the substrate material containing the composite nanoparticles on the surface obtained in S1 is immersed in the drug / fluoride mixed diluent obtained in S2, ultraviolet radiation is performed for 0.1-5 h, cleaning and nitrogen drying are performed, and the super-hydrophobic multifunctional coating is obtained. The preparation method is simple, mild in reaction condition, good in repeatability, low in cost and convenient to popularize and use, and the prepared coating material can release drugs in a sequential manner according to service environment requirements.

Description

technical field [0001] The invention belongs to the technical field of biomedical functional materials, in particular to a superhydrophobic multifunctional coating with sequential drug release and a preparation method thereof. Background technique [0002] Once blood-contact materials come into contact with blood, the proteins in the blood, especially fibrinogen, will adhere and denature on the surface of the material in a short period of time to form fibrin, which makes platelets adhere, activate and aggregate, followed by more Fibrinogen denaturation and platelet adhesion, activation and aggregation, and red blood cell network, and finally the acute formation of thrombus. At the same time, the non-specific adhesion of the protein on the surface of the material allows the body to be recognized by the macrophages of the immune system. When the macrophages cannot swallow foreign matter, they form giant cells through self-fusion and secrete cytokines (peak within 24 hours). ,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/08A61L27/28A61L27/50A61L27/54A61L29/08A61L29/16
CPCA61L31/16A61L31/08A61L27/28A61L27/507A61L27/54A61L29/08A61L29/16A61L2300/412A61L2300/602A61L2300/606A61L2300/42A61L2300/404A61L2300/41A61L2300/416A61L2300/45A61L2400/12A61L2300/216A61L2430/20
Inventor 李林华马良付平
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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