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Metal nanoparticle composite two-dimensional material heterostructure sensor and preparation method thereof

A technology of metal nanoparticles and metal nanostructures, applied in the field of biosensing, can solve problems such as undocumented two-dimensional material heterostructures, and achieve the effects of sensitive electrical signal detection capabilities, low cost, and simple methods

Pending Publication Date: 2021-07-30
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] "Preparation of Graphene by Chemical Vapor Deposition Method" discloses the preparation of a single-crystal single-layer graphene film; the Chinese patent application number is 201810537737.5, and a single-crystal single-layer graphene is prepared. There are no other records in the above-mentioned documents. Two-dimensional materials and their heterostructures

Method used

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  • Metal nanoparticle composite two-dimensional material heterostructure sensor and preparation method thereof
  • Metal nanoparticle composite two-dimensional material heterostructure sensor and preparation method thereof
  • Metal nanoparticle composite two-dimensional material heterostructure sensor and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Put the copper foil into the acetone solution for ultrasonication, wash it three times with alcohol solution, and then thoroughly wash it three times with deionized water; put the clean copper foil in the middle of the quartz tube in the quartz tube furnace, close the vacuum tube furnace, and check Airtightness; use mechanical pump and molecular pump to evacuate to below 0.013 Pa; after the temperature rises to 100°C, flow hydrogen with a flow rate of 20 sccm; after the temperature rises to 1000°C, keep the temperature for 0.5h to anneal the copper foil; 0.5 After h, feed methane gas with a flow rate of 40 sccm, keep at this temperature and flow rate for 30 minutes, and then turn off the methane gas; turn off the heater, turn off the hydrogen gas when the temperature drops to 100°C, and wait for natural cooling to room temperature to take out the grown single crystal single-layer graphene, and store the material under vacuum conditions;

[0039](2) Place the above-m...

Embodiment 2

[0050] (1) Wash the copper foil three times with acetone and hydrochloric acid solution, and then thoroughly wash it three times with deionized water; put the clean copper foil in the middle of the quartz tube in the quartz tube furnace, close the vacuum tube furnace, and check the air tightness; Vacuum to 0.67 Pa; after the temperature rises to 200°C, flow in hydrogen with a flow rate of 40 sccm, and the air pressure becomes 5.3 Pa; after the temperature rises to 1000°C, keep the temperature for 1 hour to anneal the copper foil; Methane gas, the pressure becomes 7.9 Pa, keep at this temperature and flow rate for 25min, then turn off the methane gas; turn off the heater, turn off the hydrogen when the temperature drops to 100°C, let it cool naturally to room temperature, and take out the grown single crystal monolayer graphene, and store the material under vacuum;

[0051] (2) Place the copper foil with single-layer single-crystal graphene film on 280g / L FeCl 3 Etching in the...

Embodiment 3

[0059] (1) Put the copper foil into the acetone solution for ultrasonication, wash it three times with alcohol solution, and then thoroughly wash it three times with deionized water; put the clean copper foil in the middle of the quartz tube in the quartz tube furnace, close the vacuum tube furnace, and check Airtightness; use mechanical pump and molecular pump to evacuate to below 0.013 Pa; after the temperature rises to 200°C, flow in hydrogen gas with a flow rate of 20 sccm; after the temperature rises to 900°C, keep the temperature for 1.5h to anneal the copper foil; 1.5 After h, feed methane gas with a flow rate of 40 sccm, keep at this temperature and flow rate for 30 minutes, and then turn off the methane gas; turn off the heater, turn off the hydrogen gas when the temperature drops to 100°C, and wait for natural cooling to room temperature to take out the grown single crystal single-layer graphene, and store the material under vacuum conditions;

[0060] (2) above-ment...

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Abstract

The invention discloses a metal nanoparticle composite two-dimensional material heterostructure sensor and a preparation method thereof. The metal nanoparticle composite two-dimensional material heterostructure DNA sensor is characterized in that the metal nanoparticle composite two-dimensional material heterostructure DNA sensor is composed of a metal nanostructure and a two-dimensional material; the metal nanostructure is gold nanoparticles or silver nanoparticles or copper nanoparticles; the two-dimensional material is graphene and transition metal sulfide; and the transition metal sulfide is molybdenum disulfide or tungsten disulfide. According to the invention, graphene with a nanometer field effect and TMDCs with a natural band gap and relatively strong physicochemical properties are combined to prepare a biosensor capable of detecting biomolecules such as DNA with high sensitivity. The method for preparing the metal particle composite two-dimensional material heterostructure is simple and easy to implement, and low-cost and large-scale preparation can be achieved.

Description

technical field [0001] The invention relates to a heterogeneous structure biosensor capable of detecting DNA biomolecules, belonging to the technical field of biosensing. The present invention also relates to the preparation method and application of the above-mentioned sensor. Background technique [0002] Diagnosis and treatment of diseases using DNA information is a sharp sword of precision medicine, which can bring the diagnosis and treatment of diseases to the molecular level, which has attracted widespread attention at home and abroad. [0003] Through the comprehensive analysis of the gene sequence on the DNA, valuable medical information can be formed, and finally the optimal solution for the individual can be designed to achieve early prevention, accurate diagnosis and precise treatment of diseases. DNA molecular hybridization detection is used in the screening of cloned genes, the production of restriction map, the qualitative and quantitative detection of specifi...

Claims

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Application Information

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IPC IPC(8): G01N27/414G01N27/327
CPCG01N27/4145G01N27/4146G01N27/3278
Inventor 王向玲王蕾杨诚于斌张云松常雅珣马若为
Owner SHANDONG UNIV QILU HOSPITAL
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