Cannabidiol nano analgesic patch taking bacterial cellulose-magnetic graphene oxide as base material and preparation method of cannabidiol nano analgesic patch

A technology of cannabidiol nanometer and bacterial cellulose, which is applied in the direction of non-central analgesics, medical preparations of non-active ingredients, and pharmaceutical formulas, and can solve problems such as complex matrix composition, low drug loading, and environmental pollution , to achieve high biomimetic affinity, good biocompatibility, and stable chemical structure

Active Publication Date: 2021-10-15
海南艾斯卓普科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Disadvantages of traditional cancer pain analgesic plasters: ①The backing layer is made of non-woven fabrics, polyethylene, polypropylene and other non-degradable materials, which are non-environmentally friendly materials and pollute the environment after use and discarded; ②Traditional The matrix composition of plasters or cataplasms is too complex, and the matrix material contains gel skeleton components, cross-linking agents, thickeners, fillers, cross-linking regulators and other components
So many complex substrate components complicate the production process and affect the molding rate of the product
③It does not conform to the structural design characteristics of human body bionics, poor plasticity, poor affinity with the skin, and poor comfort; ④Low mechanical strength and poor toughness lead to easy peeling; ⑤Ordinary gel materials do not have a three-dimensional network structure, and contain Low drug dose, viscous matrix seriously affects drug release
⑥The drug ingredients in traditional strong analgesic plasters mostly use toxic ingredients such as aconitine, aconitine, and araceae alkaloids, or use fentanyl, oxycodone, codeine, etc. to stimulate opioid receptors Drugs, highly addictive, seriously endangering health

Method used

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  • Cannabidiol nano analgesic patch taking bacterial cellulose-magnetic graphene oxide as base material and preparation method of cannabidiol nano analgesic patch
  • Cannabidiol nano analgesic patch taking bacterial cellulose-magnetic graphene oxide as base material and preparation method of cannabidiol nano analgesic patch
  • Cannabidiol nano analgesic patch taking bacterial cellulose-magnetic graphene oxide as base material and preparation method of cannabidiol nano analgesic patch

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A cannabidiol nano-analgesic patch based on bacterial cellulose-magnetic graphene oxide, comprising a degradable backing layer, a degradable adhesive layer 0.4 mm coated on the surface of the degradable backing layer, The nano-magnetic graphene oxide composite slow-release drug gel layer 2mm coated on the surface of the degradable adhesive layer and the bacterial cellulose immediate-release layer coated on the surface of the nano-magnetic graphene oxide composite slow-release drug gel layer Drug gel layer 2mm;

[0035] The nano-magnetic graphene oxide composite slow-release drug gel layer includes the following components: 60% of nano-bacterial cellulose powder, 10% of chitosan, 10% of nano-magnetic graphene oxide, 5% of cannabidiol, and volatile essential oil of Chinese prickly ash 3%, gel 5.5%, ternary compound penetration enhancer borneol 1.5%, menthol 3% and azone 2%;

[0036] The bacterial cellulose immediate-release drug gel layer includes the following component...

Embodiment 2

[0075] A cannabidiol nano-analgesic patch based on bacterial cellulose-magnetic graphene oxide, characterized in that it comprises a degradable backing layer, a degradable adhesive coated on the surface of the degradable backing layer 0.6mm, the nano-magnetic graphene oxide composite slow-release drug gel layer 3mm coated on the surface of the degradable adhesive layer and the bacterial fiber coated on the surface of the nano-magnetic graphene oxide composite slow-release drug gel layer Vegetarian immediate release drug gel layer 3mm;

[0076] The nano-magnetic graphene oxide composite slow-release drug gel layer includes the following components: 40% of nano-bacterial cellulose powder, 20% of chitosan, 20% of nano-magnetic graphene oxide, 5% of cannabidiol, and volatile essential oil of Chinese prickly ash 3%, gel 5.5%, ternary compound penetration enhancer borneol 1.5%, menthol 3% and azone 2%;

[0077] The bacterial cellulose immediate-release drug gel layer includes the f...

Embodiment 3

[0089] The difference between this embodiment and Embodiment 2 is only:

[0090] The nano-magnetic graphene oxide composite sustained-release drug gel layer includes the following components: 40% of nano-bacterial cellulose powder, 10% of chitosan, 10% of nano-magnetic graphene oxide, 5% of cannabidiol, and volatile essential oil of Chinese prickly ash 3%, gel 14.5%, ternary compound penetration enhancer borneol 4.5%, menthol 8% and azone 5%;

[0091] The nano-magnetic graphene oxide comprises the following components: graphene oxide 5%, ethylene glycol 15%, diethylene glycol DEG 20%, sodium acrylate 2%, sodium acetate 3% and ferric chloride 5%.

[0092] The material of the degradable backing layer is PHBV, a copolymer of PHB and PHV.

[0093] The material of the degradable adhesive layer is styrene-isoprene-styrene triblock polymer SIS.

[0094] The moisturizing agent was propylene glycol, hyaluronic acid HA, sorbitol, 1,3-butanediol and aloe vera extract.

[0095] The gel...

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Abstract

The invention discloses a cannabidiol nano analgesic patch taking bacterial cellulose-magnetic graphene oxide as a base material. The patch comprises a degradable backing layer, a degradable adhesive layer coated on the surface of the degradable backing layer, a nano magnetic graphene oxide composite sustained-release drug gel layer coated on the surface of the degradable adhesive layer, and a bacterial cellulose quick-release drug gel layer coated on the surface of the nano magnetic graphene oxide composite sustained-release drug gel layer. The invention further discloses a preparation method of the cannabidiol nano analgesic patch with the bacterial cellulose-magnetic graphene oxide as the base material. The nano bacterial cellulose degradable material and the nano magnetic graphene oxide are used as patch base materials, the polylactic acid polyester biodegradable material is used as the backing layer, the environment is protected, pollution is avoided, and the dual effects of easing pain and resisting inflammation are achieved.

Description

technical field [0001] The invention relates to a cannabidiol nano-analgesic patch using bacterial cellulose-magnetic graphene oxide as a base material and a preparation method thereof, belonging to the technical field of nano-bacterial cellulose. Background technique [0002] With economic development, urban industrialization, environmental pollution, and changes in people's lifestyles, the incidence of cancer is increasing year by year. Studies have shown that more than 70% of advanced cancer patients have obvious pain symptoms. Clinically, for some patients with severe pain and not suitable for oral administration, topical analgesic patches are often used. At present, the main analgesic ingredients of common analgesic patches are divided into two categories, one of which uses toxic ingredients such as aconitine, gauranine, and arsenic alkaloids. Although certain analgesic effects can be obtained, the drugs The ingredients are highly toxic compounds, which are absorbed th...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/05A61K47/38A61K47/04A61K47/34A61K47/44A61P29/00A61P35/00A61P19/02A61P21/00
CPCA61K9/7023A61K47/38A61K47/02A61K47/34A61K47/44A61K31/05A61P29/00A61P35/00A61P19/02A61P21/00
Inventor 刘欣黄莉刘怡云曹亮张宇左雯璐张博高雅
Owner 海南艾斯卓普科技有限公司
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