Avilamycin water-suspension nano capsule preparation and method for preparing same

Abstract

The invention discloses an abamectin water-suspended nanocapsule prepared by an emulsion polymerization method. The capsule skin is a copolymer of styrene, isocyanate, acrylic and methacrylic monomers, and the capsule core is a new dosage form of biogenic pesticide and veterinary drug abamectin, in which the content of abamectin is 0.2%-5 % (w / w); the content of the capsule skin is 5%-30% (w / w); the content of additives is 10%-35% (w / w); the amount of water. The nanocapsules are monodisperse spherical particles with a number-average particle diameter of less than 100 nanometers. Compared with traditional dosage forms, this product is characterized by water-based solvents, highly dispersed active ingredients at the nanoscale, highly stable products, and capsules that prolong the efficacy of the product. It is ultra-efficient, long-acting, low-toxic, safe, It is economical and environmentally friendly, and can be widely used to control various pests on fruit trees, vegetables, flowers, cotton, tobacco and other crops, and has important application value.

Description

technical field [0001] The invention relates to a water-suspended nanocapsule of avermectin, which belongs to the formulation technology of biological source pesticides and veterinary drugs. Background technique [0002] Abamectin is a biogenic pesticide and veterinary drug produced by microbial fermentation and purification. It is used in agricultural production to prevent and control stubborn pests and mites in fruit trees, vegetables, flowers, cotton, tobacco and other plants, such as More than 80 kinds of pests such as Liriomyza sativae, diamondback moth, spider mite, cabbage caterpillar, root-knot nematode, cotton bollworm, pear psyllid, etc.; in animal husbandry, it is used to drive and kill gastrointestinal nematodes in animals and cowhide maggots in vitro, Red-skinned fly maggot, sheep-nosed fly maggot, sheep itch mite and other parasites are currently one of the best, fastest-growing and most widely used biological source pesticides in the world. The characteristic...

AI Technical Summary

Problems solved by technology

[0003] 1. Contains a large amount of organic solvents, such as toluene, xylene, etc., causing thousands of tons of organic solvents to be discharged into nature every year, which wastes resources and seriously pollutes the environment

[0004] 2. When used, it needs to be diluted with water to form an emulsion. The active ingredients are micron-scale dispersed. The dispersion of the active ingredients is poor and the effective utilization rate is low, resulting in a large amount of pesticides, resulting in increased costs and a large amount of pesticide residues, which seriously affects the quality of agricultural products.

[0005] 3. The active ingredients have poor permeability, and the active ingredients remaining on the leaves are decomposed and wasted due to environmental factors such as light and air.

[0006] 4. The colonization of biological pesticides in the soil is poor, and the special ecological environment of the soil often inhibits the efficacy of biological pesticides, which limits the large-scale promotion of biological pesticides

[0007] Compared with emulsifiable concentrate, the microemulsion of abamectin can better solve the problems of water-based and high dispersion, but it is not a long-acting dosage form, and the release cannot be controlled. More importantly, the cost is high and the effect is not ideal