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Absorbable superfine fibre tissue remedial materials and preparing method thereof

A technology for ultra-fine fiber and tissue repair, applied in medical science, prosthesis, coating, etc., can solve the problem that the pore structure of porous membrane materials is difficult to control, etc., and achieve the effect of high strength and permeability, and simple processing technology

Inactive Publication Date: 2003-11-19
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In addition, a guiding bone repair material is composed of tricalcium phosphate particles and absorbable polymer materials to form a porous film-like material, which is bridged and covered on the site to be repaired, and the broken ends of the bone are filled with absorbable materials to guide bone cells along the Covering membrane growth, but the pore structure of porous membrane materials prepared by methods such as freeze-drying is difficult to control

Method used

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preparation example Construction

[0027] The preparation method of absorbable ultrafine fiber tissue repair material is: disperse or dissolve one or more polymer materials in a solvent to become a transparent solution or mixture, and disperse calcium phosphate particles and additives in the above solution to obtain electrospun The mixture is then added to a storage tank, connected to one or more jetting heads through a syringe pump and a pipe, and the one or more jetting heads can be connected to a single electrospinning mixture or multiple electrospinning mixtures. The jet head is connected to a high-voltage electric field with a voltage of 1 kV to 120 kV. The receiving part is grounded, and then electrospinning or electrospraying in the electric field according to the pre-designed shape to obtain the polymer ultrafine fiber material containing calcium phosphate particles and additives. After cutting or heat treatment and other post-processing procedures, or with additives Mix to obtain tissue repair materials in...

Embodiment 1

[0030] Preparation of hard tissue repair materials: absorbable synthetic polymer materials can be used in poly-L-lactic acid, poly-(D,L)-lactic acid, polyglycolic acid, polycaprolactone, polybutyrolactone, polyvalerolactone One of or a copolymer of at least two of the following monomers: L-lactic acid, (D,L)-lactic acid, glycolic acid, caprolactone, butyrolactone, valerolactone, or their blends.

[0031] For example, dissolve 1.5 grams of poly-L-lactic acid with a weight average molecular weight of about 130,000 in 10 ml of acetone, prepare a 10% (mass fraction) polymer solution, stir for 24 hours, and combine the sintered tricalcium phosphate (Ca 3 (PO 4 ) 2 ) Add 0.2g of powder to 5ml of acetone, disperse ultrasonically for 20 minutes and mix with the above polymer solution, then add it to the storage tank, connect to the jetting head through a syringe pump and a pipe, the jetting head is connected to a high-voltage positive electric field, the jetting head and the receiver The ...

Embodiment 2

[0032] Preparation of hard tissue repair materials: unsintered calcium phosphate can be synthesized with low-temperature hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), tricalcium phosphate (Ca 3 (PO 4 ) 2 ), calcium pyrophosphate (Ca 2 P 2 O 7 ), Calcium hydrogen phosphate (CaHPO 4 ), calcium hydrogen phosphate dihydrate (CaHPO 4 .2H 2 O) One or a mixture of two or more calcium phosphate salts.

[0033] For example, a certain amount of poly-L-lactic acid with a weight average molecular weight of 130,000 is dissolved in 5ml of acetone to form a 10% (mass fraction) polymer solution, and the unsintered tricalcium phosphate (Ca 3 (PO 4 ) 2 ) Add 0.2g to 5ml acetone, disperse ultrasonically for 20 minutes and mix with the above polymer solution, then add it to the storage tank, connect to the jetting head through a syringe pump and a pipe, the jetting head is connected to a high-voltage positive electric field, and the distance between the jetting head and the receiver It is controlled at a...

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PUM

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Abstract

An absorbable superfine fibre material for repair tissue is prepared from the absorbable high-molecular superfine fibre of polyester, chitosan, collagen, or hyaluronic acid, and the superfine calcium phosphate particles (hydroxy phosphorite or tricalcium phosphate) through proportional mixing in solvent, electric spinning, and post-treating. Its advantages are higher mechanical strength, good biocompatibility and proper degradation speed.

Description

1. Technical Field: [0001] The invention is an absorbable superfine fiber tissue repair material and a preparation method thereof, and belongs to the technical field of material preparation for medical surgery. 2. Background technology: [0002] Human bones and other tissues require artificial materials to repair or correct tissue defects due to diseases or trauma. Such repair materials include metals, inorganic materials, polymer materials and so on. [0003] Bone repair materials made of stainless steel or titanium alloy have high strength, low cost, and high frequency of use. However, stress shielding may occur, which may cause bone resorption, delay bone healing, and have poor tissue compatibility, which can also cause Inflammatory reaction and so on. [0004] Hydroxyapatite and tricalcium phosphate are commonly used bioceramics. Calcium phosphate cement is also commonly used for hard tissue repair. It has good biocompatibility. Hydroxyapatite also has the effect of inducing ...

Claims

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Application Information

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IPC IPC(8): A61L27/14A61L27/28A61L27/44A61L27/50
Inventor 李新松
Owner SOUTHEAST UNIV
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