Antimicrobial polymeric surfaces

a technology of polymeric surfaces and antimicrobials, applied in the field of antimicrobial polymeric surfaces, can solve the problems of inability to be effective against airborne bacteria, prone to impotence, frequent infection, etc., and achieve the effect of preventing the formation of biofilms
US20050249695A1Inactive Publication Date: 2005-11-10TRUSTEES OF TUFTS COLLEGE +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
TRUSTEES OF TUFTS COLLEGE
Publication Date
2005-11-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are disclosed for covalently derivatizing the surfaces of common materials with an antibacterial polycation, e.g., poly(vinyl-N-pyridinium bromide); the first step of the methods involves coating the surface with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner are bactericidal, i.e., they kill on contact up to 99% of deposited Gram-positive and Gram-negative bacteria, whether deposited through air or water.
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Description

RELATED APPLICATIONS

[0001] This application claims the benefit of priority to U.S. Provisional Patent Application Ser. No. 60 / 285,883, filed Apr. 23, 2001; U.S. Provisional Patent Application Ser. No. 60 / 340,078, filed Dec. 10, 2001; and U.S. Provisional Patent Application Ser. No. 60 / 368,495, filed Mar. 29, 2002.GOVERNMENT SUPPORT

[0002] This invention was made with support provided by the National Institutes of Health (Grant No. GM26698) and the National Science Foundation (Grant No. DMR-9400334); therefore, the government has certain rights in the invention.BACKGROUND OF THE INVENTION

[0003] Due to the ever-growing demand for healthy living, there is a keen interest in materials capable of killing harmful microorganisms. Such materials could be used to coat surfaces of common objects touched by people in everyday lives, e.g., door knobs, children toys, computer keyboards, telephones, etc., to render them antiseptic and thus unable to transmit bacterial infections. Since ordinary...

Claims

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