The present invention provides a cloud computing-based conference room on-line reservation management system and a cloud computing-based conference room on-line reservation method. According to the present invention, by the user management, the conference room resource management, the department information management and the user reservation audit activities, the conference participation personnel, the conference room resources and the conference time are coordinated fully, the conference room resource usage conflicts and the manpower cost needed by using the conference rooms are reduced, andthe conferencing efficiency is improved. By constructing the keywords for the user information, the conference room information, the department information and the conference room reservation results, users can query the needed information conveniently and more rapidly, and the conference room reservation efficiency is improved. According to the present invention, various resources are called according to the demands, more costs are saved for the enterprises, the conference room reservation randomness and the resource waste are avoided, and the management levels of the enterprises take new steps.