12results about How to "Improve bottle opening stability" patented technology

The invention discloses a lipoprotein-related phospholipase A2 content detection kit and a preparation method thereof, belonging to the field of detection of lipoprotein-related phospholipase A2 content. The kit consists of a reagent I and a reagent II which are independent of each other, wherein the reagent I comprises the following components: a biological buffer agent, a coagulant, a preservative, a chelating agent and water; the reagent II comprises the following components: latex particles coated with a lipoprotein-related phospholipase A2 antibody, a biological buffer agent, a surfactant, a preservative, a suspending agent and water. The latex particles coated with the lipoprotein-related phospholipase A2 antibody are prepared by adopting latex particles with the particle size of 120-180nm, and the stability, sensitivity and wide detection linear range of the kit can be effectively guaranteed. Meanwhile, the latex particles coated with the lipoprotein-related phospholipase A2 antibody are prepared by adopting a specific method, so that the bottle-opening stability and detection specificity of the kit are relatively good, and the product is suitable for popularization and application of clinical detection.

The invention discloses a neuron specific enolase content detection kit and a preparation method thereof, belonging to the field of human neuron specific enolase content detection. The detection kit is composed of mutually independent reagent I and reagent II, wherein the constituents of reagent I include a biological buffer, a preservative, a coagulation accelerator, inorganic salt and water; the constituents of the reagent II include latex particles of an envelope neuron specific enolase antibody, a biological buffer, a preservative, a suspending agent and water. According to the invention, the latex particles with particle size of 80-240nm are compositely enveloped by the neuron specific enolase monoclonal antibody and a polyclonal antibody, and thus, the kit is guaranteed to have high sensitivity and wide detection linear range, and has the advantages of being simple and convenient to operate, rapid, strong in specificity, excellent in stability and high in sensitivity, and so on.

The invention relates to a reagent packaging box, and particularly discloses a reagent packaging box used for a fully automatic chemiluminescent immunoassay analyzer (in-vitro diagnosis equipment). The reagent packaging box comprises a reagent support, a reagent bottle and a reagent box cover, wherein the reagent box support is composed of a base and side posts which are connected in a row; the side posts and the base are of an integral body; a groove is formed in the joint of the side posts and the base; as the first groove which closely matches with a feeding guide block of a reagent cabin is formed in the joint of the side posts and the base, the reagent packaging box can load and withdraw normally; the reagent packaging box packages a reagent A, a reagent B and a reaction cup in a combined manner, so that the loading process of the reagents and the reaction cup is simplified, and the automation degree of the analyzer is improved; the reagent bottle prevents volatilization of the reagent in the reagent bottle efficiently, reduces influence from outside air to product performance and prolongs de-capping stability of a diagnostic reagent.

The invention provides an angiotensin converting enzyme assay kit, and belongs to the technical field of biological detection. The kit is composed of a single reagent, wherein the single reagent comprises the following components: 50 to 100 mmol / L of a buffer solution, 200 to 500 mmol / L of an inorganic salt, 5 to 20 mg / L of potassium ferrocyanide, 0.1 to 5.0% of a surfactant, 10 to 100 mg / L of a protective agent, 0.05 to 0.1% of an antiseptic, and 0.5 to 2.0 mmol / L of phenylpropionylaminoglycylglycine; wherein the pH value is 8.20 + / -0.05. Compared with a conventional ACE (Angiotensin Converting Enzyme) detection kit, the kit has better bottle opening stability and bilirubin interference resistance, and meanwhile, the repeatability, the linear range, the precision and the accuracy of the reagent are not influenced. The invention also provides a preparation method and application of the angiotensin converting enzyme assay kit.

The invention discloses a neuron specific enolase content detection kit and a preparation method thereof, belonging to the field of human neuron specific enolase content detection. The detection kit is composed of mutually independent reagent I and reagent II, wherein the constituents of reagent I include a biological buffer, a preservative, a coagulation accelerator, inorganic salt and water; the constituents of the reagent II include latex particles of an envelope neuron specific enolase antibody, a biological buffer, a preservative, a suspending agent and water. According to the invention, the latex particles with particle size of 80-240nm are compositely enveloped by the neuron specific enolase monoclonal antibody and a polyclonal antibody, and thus, the kit is guaranteed to have high sensitivity and wide detection linear range, and has the advantages of being simple and convenient to operate, rapid, strong in specificity, excellent in stability and high in sensitivity, and so on.

The invention discloses a detection kit for galectin-3 and a preparation method thereof. The detection kit comprises reagent I and reagent II which are independent of each other. Reagent I comprises a biobuffer, a coagulation accelerator, a preservative, a chelating agent, an inorganic salt and water; and reagent II comprises latex particles, the biobuffer, a surfactant, the preservative, a suspending agent, a blocking agent and water, wherein galectin-3 antibodies are coated by the latex particles. The latex particles with a particle size of 130 to 270nm are used for coating galectin-3 antibodies via chemical crosslinking, so that stability, sensitivity and relatively wide detection linear range of the detection kit are ensured. The detection kit possesses advantages such as excellent stability, high sensitivity and specificity, and convenient operation process; and is suitable for population and application.

The invention provides a small and dense low-density lipoprotein cholesterol detection reagent. The detection reagent comprises a first reagent and a second reagent. Under the combination of inorganicsalt ions, a stabilizer, a buffer solution, peroxidase and the like, the kit is good in bottle opening stability; in addition, the anti-interference capability of the reagent is high, and interference of bilirubin, hemoglobin, chyle and intralipid can be effectively eliminated.

The invention discloses a neutrophile granulocyte gelatinase related lipid transport protein detection kit and a preparation method thereof. The detection kit is composed of a reagent I and a reagent II independent from each other; the reagent I comprises the components of biobuffer, surfactant, coagulant, preservative, stabilizer, blocker, chelating agent and water; and the reagent II comprises the components of rubber latex particle of enveloping neutrophile granulocyte gelatinase related lipid transport protein antibody, biobuffer, chelating agent, surfactant, preservative, suspending agent, sealing agent, stabilizer and water. According to the invention, the neutrophile granulocyte gelatinase related lipid transport protein antibody of the detection kit can not only be combined with the neutrophile granulocyte gelatinase related lipid transport protein antigen, but also be combined with the MMP-9 / NGAL (matrix metallopeptidase-9 / (neutrophil gelatinase associated lipocalin) compound, thereby avoiding the influence of MMP-9 / NGAL compound to the detecting result, and having the advantages of good specificity, high sensitivity, wide linear range, favorable stability and the like.

The invention discloses a lipoprotein-related phospholipase A2 content detection kit and a preparation method thereof, belonging to the field of detection of lipoprotein-related phospholipase A2 content. The kit consists of a reagent I and a reagent II which are independent of each other, wherein the reagent I comprises the following components: a biological buffer agent, a coagulant, a preservative, a chelating agent and water; the reagent II comprises the following components: latex particles coated with a lipoprotein-related phospholipase A2 antibody, a biological buffer agent, a surfactant, a preservative, a suspending agent and water. The latex particles coated with the lipoprotein-related phospholipase A2 antibody are prepared by adopting latex particles with the particle size of 120-180nm, and the stability, sensitivity and wide detection linear range of the kit can be effectively guaranteed. Meanwhile, the latex particles coated with the lipoprotein-related phospholipase A2 antibody are prepared by adopting a specific method, so that the bottle-opening stability and detection specificity of the kit are relatively good, and the product is suitable for popularization and application of clinical detection.

The invention, which is applicable to the technical field of medical detection, provides an ischemia modified albumin detection kit, which comprises an R1 reagent and an R2 reagent. The R1 reagent comprises the following components: 0.02 to 0.1 mol / L of phosphate buffers, 5 to 10mmol / L of a cobalt chloride solution, 0.02 to 0.08g / L of preservatives, and 0.5 to 1.5g / L of stabilizers. The R2 reagentincludes the following components: 0.05 to 0.15 mol / L of phosphate buffers, 6 to 15 mmol / L of dithiothreitol, 0.3 to 0.7 g / L of surfactants, and 0.02 to 0.08 g / L of preservatives. The kit can be applied to detection of the content of ischemia-modified albumin in the human serum; the detection result has high repeatability and high precision; and the highest detection range can reach 200.4 U / mL. The kit has the great linical application value.

The invention discloses a small and dense low-density lipoprotein cholesterol detection kit, and belongs to the technical field of biological detection. The small and dense low-density lipoprotein cholesterol detection kit comprises a reagent A and a reagent B, wherein the reagent A comprises the following components: cholesterol esterase, cholesterol oxidase, peroxidase, a buffer solution, a stabilizer, a first surfactant and a preservative; and the reagent B comprises the following components: 4-aminoantipyrine, peroxidase, a buffer solution, a stabilizer, a second surfactant, a preservative and a reaction accelerator. The small and dense low-density lipoprotein cholesterol detection kit provided by the invention overcomes the defects of the existing small and dense low-density lipoprotein cholesterol detection kit, and has the advantages of strong anti-interference performance, high specificity, high accuracy, wide linear range, good bottle opening stability and the like; and a safe, rapid, accurate and pollution-free detection means is provided for detection of small and dense low-density lipoprotein cholesterol.

The invention relates to a reagent packaging box, and particularly discloses a reagent packaging box for a fully automatic chemiluminescence immunoassay analyzer (in vitro diagnostic equipment), including a reagent box holder, a reagent bottle and a reagent box cover, and the reagent box holder consists of a base and a side-by-side Composed of connected side columns, the side column and the base are integrated, the connection between the side column and the base is provided with a first groove; the connection between the side column and the base is provided with a first groove, the first groove and the reagent The feeding guide block of the warehouse is closely matched, so that the reagent packaging box can be loaded and withdrawn normally; and the reagent packaging box is combined with reagent A, reagent B and reaction cups, which simplifies the loading process of reagents and reaction cups, and improves the automation of analytical instruments. Degree; the reagent bottle effectively prevents the volatilization of the reagent in the reagent bottle, reduces the influence of the outside air on the product performance, and prolongs the stability of the diagnostic reagent when it is opened.