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Blood plasma lipide component adsorbing separation polymer porous film material, its preparing and use

A technology of adsorption, separation and polymer, which is applied in the field of biomedical materials and medical device materials, and can solve problems such as complex preparation methods and engineering, and difficulties in large-scale production

Inactive Publication Date: 2007-08-29
SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, the medium carriers of the above-mentioned relatively good LDL adsorbents are all polymer gel systems. Whether their mechanical strength can withstand the pressure and multi-directional shear force associated with the dynamic perfusion process of blood purification for a long time? At the same time, the hemocompatibility and biological toxicity of its adsorbent materials need further research, and the preparation method and engineering are relatively complicated, and large-scale production is difficult.

Method used

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  • Blood plasma lipide component adsorbing separation polymer porous film material, its preparing and use
  • Blood plasma lipide component adsorbing separation polymer porous film material, its preparing and use
  • Blood plasma lipide component adsorbing separation polymer porous film material, its preparing and use

Examples

Experimental program
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Effect test

Embodiment 1

[0095] Cut the medical polypropylene non-woven fabric with an average pore size of 0.1 μm into 5cm×5cm 2 The samples were ultrasonically cleaned in acetone and water for 15 to 30 minutes, and dried in vacuum for later use. Then, soak the above-mentioned sample in an aqueous solution containing 10% (mass percentage) of acrylic acid monomer, which additionally contains 1.0% ferrous sulfate polymerization inhibitor and 0.5% sulfuric acid catalyst. After soaking for 24 hours, place the sample in 60 In the radiation field of Co γ-ray source, the total cumulative irradiation dose is controlled to 30kGy. After the above-mentioned irradiation treatment sample was taken out, it was washed, dried, weighed and calculated to obtain a copolymerization grafting rate of acrylic acid of 30 wt%, and the corresponding surface carboxyl group content of the obtained porous membrane carrier material was 25 μmol / cm 2 , ATR-FITR infrared spectrum analysis found that the sample was at 1700cm -1 A n...

Embodiment 2

[0097] Cut the 0.45μm medical polypropylene non-woven fabric into 5cm×5cm 2 The samples were ultrasonically cleaned in acetone and water for 15 to 30 minutes, and dried in vacuum for later use. The above samples were then soaked in an aqueous solution containing 15% acrylic acid monomer. The solution contains 0.5% ferrous sulfate polymerization inhibitor and 1.0% sulfuric acid catalyst at the same time. After soaking for 24 hours, the sample is placed in 60 In the radiation field of the Co γ-ray source, the total cumulative irradiation dose is controlled to be 20kGy. After the above-mentioned irradiation treatment sample was taken out, it was washed, dried, weighed and calculated to obtain a copolymerization grafting rate of acrylic acid of 84%, and the surface carboxyl content of quantitative titration was 70 μmol / cm 2 . ATR-FITR infrared spectrum analysis found that at 1700cm -1 A strong absorption peak appeared at , corresponding to the characteristic absorption signal ...

Embodiment 3

[0099] Take a 250ml volumetric three-neck bottle, after removing water and oxygen, quickly put 25 grams of p-toluenesulfonic acid into it under the protection of nitrogen, then slowly add 200ml of dry pyridine with 25 grams of cholesterol dropwise, the solution gradually turns pink. After continuing to stir and react for 24 hours, the reaction solution was poured into 5% potassium carbonate solution, stirred in an ice bath for 1 hour, the filtered solid was dissolved in dichloromethane, washed repeatedly with water, separated, and dried overnight over anhydrous sodium sulfate. After suction filtration, the dichloromethane was spin-dried and recrystallized in acetone to obtain p-toluenesulfonic acid-protected cholesterol ligand intermediates (CHOL-OTs). Then move it into a reaction flask that has been dehydrated and deoxygenated, add 20ml of 1,4-butanediol, use dioxane as a solvent, and reflux for 24 hours, remove the solvent under reduced pressure, and dissolve the residue in ...

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Abstract

This invention aims at providing a plasma lipid composition selective adsorption separation porous membrane carrier materials, preparation methods and related applications. The porous membrane carrier used the average pore size of 0.05 m ~ 100 u medical nonwoven polymer as the starting raw materials, through a total of 60 Co-ray irradiation grafting copolymerization polyacrylic acid surface modification, it further fixed the cholesterol ligand by carboxyl and containing 0 to 10 carbon atoms hand cholesterol arm of covalent ligand, finally get the polymer porous membrane carrier materials of plasma lipid selective adsorption separation ability. The invention related to the preparation method is simple, safe, effective and easy to promote large-scale production. With good material blood compatibility, it can be used as a plasma lipid composition adsorption separation of hyperlipidemia, dynamic perfusion of clinic high plasma patients blood purification and waste blood separation renewable auxiliary materials.

Description

technical field [0001] The invention provides a novel functional polymer porous membrane material, a preparation method and its application in plasma lipid component adsorption or separation. The polymer porous membrane material provided by the invention relates to selective adsorption and separation medium materials of plasma lipid components in clinical blood purification applications, and belongs to the field of biomedical materials and medical device materials. A new type of polymer porous membrane involved in this invention is made of medical grade polymer non-woven fabrics with different average pore sizes as the starting material. Prepared by the same process. Background technique [0002] At present, cardiovascular and cerebrovascular system diseases have developed into one of the three major clinical diseases that threaten human health. Every year, 8 to 10 million people die of cardiovascular-related diseases worldwide. According to the statistics of "China Cardio...

Claims

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Application Information

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IPC IPC(8): B01D67/00A61M1/36B01J20/26B01J20/28B01D71/78
Inventor 曹阿民侯小东张涛
Owner SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
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