Method for synthesizing 3-aryl allyl group ether

Abstract

The present invention relates to synthesis of organic material, and is especially process of synthesizing 3-arylallyl ether. Inside solvent of nitromethane, dichloromethane, ethyl cyanide, trichloromethane, toluene or tetrahydrofuran, and in the presence of catalyst of ferric chloride, indium chloride, zinc dichloride, copper bromide, ferric perchlorate or magnesium perchlorate, aromatic aldehyde and allylalkoxyl silane are reacted to produce 3-arylallyl ether. Adding trimethylchlorosilane into indium chloride catalyst can result in even high catalytic effect. The present invention has the advantages of simple operation, high safety, environment friendship, etc. and the synthesized organic intermediate has wide application.

Description

technical field [0001] The invention relates to a method for synthesizing organic matter, in particular to a method for synthesizing 3-aryl allyl ether. technical background [0002] 3-Aryl allyl ethers are an important class of organic compounds, which are mainly obtained from the reaction of acetals or aldehydes with allylating reagents under the catalysis of Lewis acids. In recent years, there are generally three types of allylation reagents for the synthesis of 3-aryl allyl ethers: allyl bromide, allyl tin, and allyl silane. When allyl bromide is used as the allylation reagent, an equivalent amount of metal is required as a reducing agent such as: iron, magnesium, zinc, copper, manganese, aluminum, indium, samarium, etc., but the metal cannot be recycled, and allyl bromide Bromine has certain toxicity and is harmful to the human body and the environment; allyl tin itself is relatively unstable and has certain toxicity, and requires equivalent metal catalysts such as: ti...

AI Technical Summary

Problems solved by technology

When allyl bromide is used as the allylation reagent, an equivalent amount of metal is required as a reducing agent such as: iron, magnesium, zinc, copper, manganese, aluminum, indium, samarium, etc., but the metal cannot be recycled, and allyl bromide Bromine has certain toxicity and is harmful to the human body and the environment; allyl tin itself is relatively unstable and has certain toxicity, and requires equivalent metal catalysts such as: titanium tetrachloride, aluminum trichloride , tin tetrachloride; no matter from an economic point of view or from an environmental point of view, it is more unfavorable to use allyl bromide or allyl tin as an allylation reagent, so allyl silane is allyl Reagent of choice for alkylation

But allyl chlorosilane is relatively active, and its participation in the reaction needs to be carried out under anhydrous conditions, and the scope of substrates is also greatly limited; allyl alkylsilane often requires complicated reaction conditions as an allylation reagent, such as Requires equivalent Lewis acid catalyst (titanium tetrachloride, aluminum trichloride, boron trifluoride ether, etc.), anhydrous low temperature and other conditions, using acetal two-step synthesis

Images