Preparing method of proton pump inhibitor biological adhesive preparation

Abstract

The invention discloses a preparing method of a proton pump inhibitor biological adhesive preparation, which comprises the following steps: selecting peroral proton pump inhibitor medicaments, alkaline substances, carrier materials and biological adhesive materials to prepare the adhesive preparation by a preparation preparing method; making enteric coating on the outer layer of the preparation; and finally, preparing the medical preparation containing the adhesive materials. The proton pump inhibitor biological adhesive preparation prepared by the preparing method has the advantages of indissolvableness in gastric acid, coating film degradation in intestinal juice, and the like, is adhered to the intestinal mucosa for slowly releasing, and is suitable for treating gastric ulcer and duodenal ulcer.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for preparing a bioadhesive pharmaceutical preparation of a proton pump inhibitor. Background technique [0002] Since the early 1980s, studies have shown that highly negatively charged carboxylated polymers (such as acrylic polymers) have significantly high bioadhesion and low biotoxicity to human conjunctival epithelial cells cultured in vitro[ Park K. et al, Int J Pharm 1984, 19: 107-127]; gastrointestinal tract adhesion experiments in vivo and in vitro in animals have proved that the interaction between acrylic polymers (such as Polycarbophil) and mucin on the surface of the gastrointestinal tract makes the stomach The intestinal emptying time is significantly prolonged, so it can be concluded that this type of polymer can be used as a bioadhesive material for oral drug release preparations [Ch'ng H.S. et al, J Pharm Sci 1985, 74: 399-405]. It is believ...

AI Technical Summary

Problems solved by technology

It has been reported that pantoprazole is made into slow-release preparations and antibacterial drugs in combination to treat Helicobacter pylori infection and peptic ulcer [United States Patent: 6274173], or lansoprazole is made into enteric-coated preparations (tablet, micro pills or granules), the preparation contains alkaline substances (sodium hydroxide, potassium hydroxide or sodium carbonate) to maintain the alkaline environment of the preparation to maintain the stability of the drug, and the prepared preparation is used for gastrointestinal ulcers Treatment [United States Patent: 7276253], there are no relevant literature reports and patents on making proton pump inhibitors into adhesive preparations (tablets, microspheres, granules, etc.)