Magnesium-based bone filling adhesive and preparation method and application thereof

An adhesive and cohesive technology, which is applied in application, surgical adhesives, medical science, etc., can solve the problems of slow strength development, poor biocompatibility, poor collapse resistance, etc., and achieve low raw material cost and high cohesiveness. Strong, good anti-collapse effect

Inactive Publication Date: 2011-12-14
天津美基生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to 1) overcome the shortcomings of poor biocompatibility such as polymethyl methacrylate, and provide a bone filling adhesive with good bonding performance; 2) overcome the low early strength and slow strength development of calcium phosphate cement , poor collapsibility, and the slurry is easily washed away by bleeding in the operation area, etc., providing a potassium salt-based magnesium-based bone filling adhesive with good collapsibility and fast strength; 3) Overcoming the existing magnesium phosphate bone filling adhesive. The ammonia gas produced by the cement hydration reaction is harmful to the human body and other disadvantages. Invented a potassium salt type magnesium-based bone filling adhesive with high initial strength, good biocompatibility, injectability, and good biodegradability.

Method used

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  • Magnesium-based bone filling adhesive and preparation method and application thereof
  • Magnesium-based bone filling adhesive and preparation method and application thereof
  • Magnesium-based bone filling adhesive and preparation method and application thereof

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Effect test

Embodiment 1

[0016] Alkaline oxides are taken in parts by weight, and 20% to 30% of one of magnesium oxide, calcium oxide, zinc oxide, strontium oxide, and aluminum oxide is selected. The hydrogen phosphate is sodium dihydrogen phosphate, disodium hydrogen phosphate, dibasic phosphate Potassium hydrogen phosphate, dipotassium hydrogen phosphate or a mixture of two or more 15-40%, magnesium phosphate 20%-40%, calcium phosphate salt (α, β)-tricalcium phosphate, tetracalcium phosphate, octacalcium phosphate One or both of calcium, calcium hydrogen phosphate anhydrous, calcium hydrogen phosphate dihydrate, calcium dihydrogen phosphate, calcium pyrophosphate, hydroxyapatite, fluoroapatite, strontium apatite, and carbonate-containing apatite and mixtures of the above. 5-10% starch, 5-10% starch, uniformly mixed to obtain a powdery solid phase component with a particle size of less than 20 μm. In addition, sugars include polysaccharides, sugar derivatives, glucose, sucrose, dextrin, cellulose, c...

Embodiment 2

[0024] Dibasic calcium phosphate dihydrate and calcium carbonate were weighed at a molar ratio of 2:1, mixed thoroughly, heated to 950°C in a muffle furnace, kept for 3 hours, taken out and ball milled for 10 hours to obtain β-tricalcium phosphate. Magnesium oxide was calcined at a high temperature of 1500°C and kept for 1 hour. Weigh 1.0g β-tricalcium phosphate, 2.2g magnesium oxide, 3.6g potassium dihydrogen phosphate, 2.7g magnesium phosphate, 0.5g starch, the particle size is less than 20μm, and mix uniformly to form a solid phase powder. Weigh 2.0 g of sodium dihydrogen phosphate, 0.5 g of sucrose, and 0.5 g of glucose and dissolve them fully in 10 ml of 0.1 mol / L phosphoric acid solution to obtain a solidified solution. The solidified liquid is poured into the solid phase powder at a liquid-solid ratio of 0.3 (ml / mg), and mixed uniformly in a vessel to obtain a magnesium-based bone filling adhesive.

Embodiment 3

[0026] Calcium hydrogen phosphate dihydrate and calcium carbonate were weighed at a molar ratio of 2:1, mixed thoroughly, heated to 1250°C in a muffle furnace, kept for 3 hours, taken out and ball milled for 10 hours to obtain α-tricalcium phosphate. Magnesium oxide was calcined at a high temperature of 1600°C and kept for 1 hour. Weigh 1.0g α-tricalcium phosphate, 2.2g magnesium oxide, 3.6g potassium dihydrogen phosphate, 2.7g magnesium phosphate, 0.5g starch, the particle size is less than 20μm, and mix uniformly to form a solid phase powder. Weigh 1.0 g of disodium hydrogen phosphate, 1.0 g of sodium dihydrogen phosphate, and 0.8 g of glucose and fully dissolve them in 10 ml of 0.1 mol / L phosphoric acid solution to obtain a solidified solution. The solidified liquid is poured into the solid phase powder at a liquid-solid ratio of 0.4 (ml / mg), and mixed uniformly in a vessel to obtain a magnesium-based bone filling adhesive.

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Abstract

The invention discloses a magnesium-based bone filling adhesive and its preparation method and application. The adhesive material is composed of a solid phase component and a liquid phase component, wherein the solid phase component is composed of basic oxide, Calcium phosphate, hydrogen phosphate, magnesium phosphate, and starch are mixed evenly; the liquid phase component is prepared by dissolving sugar and hydrogen phosphate in aqueous phosphoric acid. Mix the above-mentioned solid phase components and liquid phase components evenly to form a pasty cement slurry, which is used for filling and repairing bone tissue trauma and treating osteoporosis, especially for the adhesion of bones, tendons, ligaments and prostheses. Bonding and fixing, avoiding the disadvantages of the existing calcium phosphate cement, such as low early strength, non-viscosity, easy collapse, poor biodegradability and magnesium phosphate cement containing ammonium salt, and achieved good results. And it has the characteristics of low raw material cost, simple preparation method, high strength, strong cohesiveness, good collapse resistance, good biodegradability, no ammonia gas, etc., and can be directly injected into the lesion with a syringe or filled into the body after curing and molding. It is very convenient to use, and it can also be used for bonding and fixing building materials such as metal, ceramics, and plastics.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and relates to a product for forming a magnesium-based bone filling adhesive, a magnesium-based bone filling adhesive material and its preparation method and application, and relates to a high-strength, Good adhesiveness, injectability, anti-collapse and biodegradable magnesium-based filling adhesive material, which can be used for filling and repairing bone tissue defects and bonding of bones, fractures, tendons, ligaments and prostheses Knots are secured with a magnesium-based filler adhesive. Background technique [0002] The inorganic component of human bone is mainly calcium phosphate, accounting for 85%, including hydroxyapatite and amorphous calcium phosphate, and contains CO 3 2- , C1 - , F - 、Na + 、K + , Mg 2+ and other impurity ions and trace elements such as Sr and Zn. In the mid-1980s, Brown and others invented calcium phosphate bone cement. The main components are hydroxya...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/00
Inventor 不公告发明人
Owner 天津美基生物医药科技有限公司
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