Method for preparing medical porous metal implant material

A technology for implant materials and porous metal, which is applied in the field of preparation of medical metal implant materials, can solve the problems affecting the processing and mechanical properties of porous tantalum materials, such as ductility, compressive strength, and insufficient bending strength, so as to improve biocompatibility and biological safety, good pore size uniformity of the finished product, and uniform pore distribution

Active Publication Date: 2014-01-15
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, porous tantalum, which is used as a medical implant material for compact bone tissue such as dental bone, has obvious deficiencies in mechanical properties such as ductility, compressive strength, and bending strength, and will affect subsequent research on porous tantalum. Processing of the material itself, such as cutting of molded parts, etc.

Method used

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  • Method for preparing medical porous metal implant material
  • Method for preparing medical porous metal implant material
  • Method for preparing medical porous metal implant material

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Embodiment 1: Take paraffin wax, tantalum powder and ethyl cellulose with an average particle size less than 43 microns and an oxygen content of less than 0.1% and mix them uniformly to form a mixed powder, wherein paraffin wax accounts for 8%, ethyl cellulose accounts for 27%, tantalum powder accounts for 65%, all in volume percentage. Granulation: The mixed powder is granulated into round particles with a particle diameter of 10-13 μm at a working temperature of 510-520° C. and a working pressure of 12-13 MPa. Injection molding: the temperature for injecting the round particles into the mold is 465-490° C. and the pressure is 83-85 MPa. Demolding time: 6~7S. Degreasing treatment: vacuum degree 10 -4 Pa, rise from room temperature to 400°C at a rate of 1-3°C / min, hold for 60-120 minutes, rise from 400°C to 600-800°C at a rate of 1.5-2.5°C / min, and hold for 180-240 minutes. Vacuum sintering: sintering in a vacuum furnace, the sintering temperature is 2000°C, the heat...

Embodiment 2

[0030] Embodiment 2: Weigh polyvinyl alcohol, tantalum powder with an average particle size less than 43 microns and an oxygen content of less than 0.1%, and sodium bicarbonate and mix them uniformly to form a mixed powder, wherein polyvinyl alcohol accounts for 6%, sodium bicarbonate accounts for 29%, tantalum Powder accounted for 65%, all in volume percentage. Granulation: The mixed powder was granulated into round particles with a particle diameter of 20 μm at a working temperature of 450° C. and a working pressure of 15 MPa. Injection molding: the temperature of injecting the round particles into the mold is 540° C. and the pressure is 90 MPa. Demolding time: 9S. Degreasing treatment: vacuum degree 10 -4 Pa, raise the temperature from room temperature to 400°C at a heating rate of 1°C / min, and hold for 60 minutes; then raise the temperature from 400°C to 800°C at a heating rate of 2.5°C / min, and hold for 180 minutes. Vacuum sintering: sintering in a vacuum furnace, the ...

Embodiment 3

[0032] Embodiment 3: take by weighing zinc stearate, average particle diameter less than 43 micron oxygen content less than 0.1% tantalum powder and methyl cellulose and mix uniformly into mixed powder, wherein zinc stearate accounts for 10%, methyl cellulose accounts for 10%. 23%, tantalum powder accounted for 67%, both by volume percentage. Granulation: The mixed powder was granulated into circular particles with a particle diameter of 10 μm at a working temperature of 650° C. and a working pressure of 12 MPa. Injection molding: the temperature of injecting the round particles into the mold is 380° C. and the pressure is 72 MPa. Demolding time: 6S. Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 400°C at a heating rate of 3°C / min and hold for 120 minutes; then at a heating rate of 1.5°C / min from 400°C to 750°C for 240 minutes. Vacuum sintering: sintering in a vacuum furnace, the sintering temperature is 2200°C, the heat preservation is 2.5 hours, an...

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Abstract

A preparation method for a medical porous metal implant material comprising mixing tantalum powder, a pore-forming agent, and a forming agent into a powder mixture, then granulating, injecting into a mold for forming, demolding, degreasing, sintering, and performing a heating process to produce the medical porous metal implant material for dental bone tissue replacement; the pore-forming agent is one or multiple of sodium bicarbonate, urea, sodium chloride, methyl cellulose, and ethyl cellulose, and the forming agent is one or multiple of polyvinyl alcohol, stearic acid, zinc stearate, paraffin, and synthetic rubber; the degreasing process comprises: gradually increasing the temperature to 400 to 800°C at a speed of 0.5 to 3°C / min, introducing argon gas to form a protective atmosphere, and maintaining the temperature for 60 to 240 minutes. Measurements show that the porous tantalum material prepared using the method has an impurity concentration lower than 0.2%. The density reaches 11.67 to 13.34 g / cm3, the porosity reaches 20% to 30%, and the pore diameter reaches 12 to 25 mum. The elastic modulus reaches 4.5 to 6.0 Gpa, the elongation rate reaches 12.0% to 13.8%, the bending strength reaches 120 to 150 Mpa, and the compressive strength reaches 90 to 110 Mpa.

Description

technical field [0001] The invention relates to a preparation method of a medical metal implant material, in particular to a preparation method of a medical porous metal implant material. Background technique [0002] Porous medical metal implant materials have important and special uses in the treatment of bone tissue trauma, femoral tissue necrosis, and replacement of dense bone tissue such as dental bone. The common materials of this type include porous metal stainless steel and porous metal titanium. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected and evenly distributed, or it should be consistent with the growth of human bone tissue as needed. , and reduce the weight of the material itself, so that it is suitable for human implantation. [0003] As for the refractory metal tantalum, due to its excellent biocompatibility, its porous material is e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/56C22C1/08C22C27/02
CPCB22F3/1121A61L27/56A61L27/047C22C27/02
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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