Intelligent nano-silver hydrogel

A hydrogel and nano-silver technology, applied in the directions of inorganic active ingredients, sexually transmitted diseases, aerosol delivery, etc., can solve the problems of increasing the production process, raw materials and costs, and achieve easy mass production, good stability, and low resistance. good bacteria effect

Inactive Publication Date: 2013-06-05
WUHAN WORLDNER UNITED PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above method requires multi-step synthesis, and a large amount of reducing agent, stabilizer, polymer g

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] At room temperature, dissolve 0.12g of hydroxypropyl methylcellulose in 100mL of double-distilled water to form a hydroxypropylmethylcellulose solution with a molar concentration of 0.01ml; dissolve 0.17g of silver nitrate in 10mL of double-distilled water, Form a silver nitrate solution with a molar concentration of 0.1m01 / L; take 10mL hydroxypropyl methylcellulose solution and 1.5mL silver nitrate solution and mix evenly to make the molar ratio 1:1.5. The mixed solution was irradiated under 100W self-ballasted fluorescent high-pressure mercury for 2.5 hours to prepare nano-silver hydrogel.

Embodiment 2

[0031] This embodiment is the structural characterization of the silver nano-antibacterial material in Example 1, specifically as follows: Adopt Tecnai G2F20 S-Twin 200 KV field emission transmission electron microscope to measure the morphology and elemental composition of silver nanoparticles in the nano-silver hydrogel for characterization . The sample preparation is to dissolve the nano-silver hydrogel in ultrapure water, precipitate with absolute ethanol and disperse it on the TEM copper grid. It can be seen from the TEM image that the particle size of nano-silver is between 5-10nm, and the particle size is relatively uniform. The sample mainly contains four elements: Ag, S, C, and O. The 20 values ​​of the characteristic diffraction peaks of the sample measured by X-ray diffraction are 38.2', 44.4', 64.5', 77.5' in turn, and the displayed diffraction crystal planes are (111), (200), (220) and (311) respectively Compared with the standard crystalline silver card (PDFg04-...

Embodiment 3

[0033] In this embodiment, Escherichia coli and Staphylococcus aureus are selected as representatives of Gram-negative bacteria and positive bacteria, and the bacteriostatic test of Example 1 is carried out.

[0034] The operation steps of the inhibition zone test are as follows: sterilize and dissolve the LB agar solid medium and pour it into a sterilized petri dish. Spread it evenly with a sterile coating stick, then use sterile tweezers to pick up the Oxford cup, gently place it in the middle of the plate, and then let it stand for a while so that it can be fixed on the plate. Then pipette 2mL of nano-silver hydrogel solution into the Oxford cup, and use sterile water as a blank control, and make three parallel samples for each bacterium. The medium was cultured in an incubator at 37°C for 24 hours, and then the diameters of the inhibition zones were measured with a ruler, and the average value was taken. After checking the nano silver hydrogel has obvious antibacterial ef...

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Abstract

The invention discloses intelligent nano-silver hydrogel. A preparation process of the intelligent nano-silver hydrogel comprises the following steps of: 1, dissolving silver nitrate and hydroxypropyl methyl cellulose used as raw materials into purified water to prepare a hydroxypropyl methyl cellulose-silver nitrate complex; and 2, on the basis of taking a complex solution as a precursor, reducing silver ions in the precursor solution by using hydrate electrons and free radicals produced by ultraviolet irradiation to prepare nano-silver gel, coating nano-silver by the hydroxypropyl methyl cellulose through the action of sulfydryl and silver, and forming hydrogel by amino and carboxylic acid of the hydroxypropyl methyl cellulose as hydrophilic residue network water molecules to prepare the nano-silver hydrogel. Compared with the nano-silver hydrogel prepared by using the traditional method, the intelligent nano-silver hydrogel disclosed by the invention has the advantages of few raw materials, simple preparation method, good antibacterial effect, good stability and the like and can have no remarkable change after being exposed in air for one year.

Description

technical field [0001] The invention relates to a medical hydrogel composition, in particular to an intelligent nano-silver hydrogel for gynecological treatment. Background technique [0002] With the extensive use of chemicals such as antibiotics, disinfectants, and fungicides, the population of microorganisms mutating due to drug resistance is increasing. As an inorganic antibacterial material, nano silver can effectively kill pathogenic microorganisms such as bacteria, fungi, and mycoplasma, and has antibacterial activity unmatched by other antibacterial materials. Nano-silver has the advantages of antibacterial broad-spectrum, high efficiency, long-lasting effect, not affected by pH value, safety and environmental protection, etc. It has been recognized by more and more people and has become an ideal antibacterial material. [0003] Generally, hydrogel is formed by introducing a part of hydrophobic groups and hydrophilic residues into water-soluble polymers with a netwo...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K33/38A61K47/38A61P15/00A61P15/02A61P31/04A61P31/02
Inventor 丁虹
Owner WUHAN WORLDNER UNITED PHARMA
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