Nano-microcapsule coated intravascular stent of core-shell structure and preparation method of intravascular stent

A core-shell structure and vascular stent technology, applied in the field of medical devices, can solve the problem of high thrombosis rate, and achieve the effects of high preparation efficiency, cell adhesion, and repair.

Inactive Publication Date: 2014-02-12
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although rapamycin and paclitaxel can inhibit endothelial hyperplasia, delay the healing of injured endothelium and the coverage of endothelium on the stent, and inhibit the occurrence of early in-stent restenosis to a certain extent, the rate of late thrombosis is still relatively low. high

Method used

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  • Nano-microcapsule coated intravascular stent of core-shell structure and preparation method of intravascular stent
  • Nano-microcapsule coated intravascular stent of core-shell structure and preparation method of intravascular stent
  • Nano-microcapsule coated intravascular stent of core-shell structure and preparation method of intravascular stent

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Experimental program
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Effect test

Embodiment 1

[0026] In this embodiment, the inner coating is β-elemene injection, and the outer coating is a chitosan-acetic acid solution of platelet membrane glycoprotein receptor IIIa antagonist sz-21, which is sprayed under corresponding experimental conditions.

[0027] (1) Put the 316L stainless steel bare metal bracket into 75% ethanol solution, acetone, and distilled water for 5-10 minutes, and then put it into 75% ethanol solution, acetone, and distilled water for 5-10 minutes to remove the residual oil, dust and other impurities on the surface of the bracket, and then soak it in chromic acid lotion 10-20min, then thoroughly cleaned with distilled water for 20min by ultrasonic oscillation, and then dried in a vacuum oven at 50°C for 24 hours.

[0028] (2) Take 2mg sz-21 powder and dissolve it in 1ml90% acetic acid solution, mix to make a drug solution, then weigh 20mg chitosan and dissolve it in the aforementioned 1ml drug solution, magnetically stir to make the chitosan dissolve c...

Embodiment 2

[0033] The inner coating of this embodiment is the PLGA electrospray liquid containing the antiproliferative drug docetaxel, and the outer coating is the chitosan acetate solution of the platelet membrane glycoprotein receptor IIIa antagonist sz-21, carried out under corresponding experimental conditions spraying.

[0034] (1) Put the 316L stainless steel bare metal bracket into 75% ethanol solution, acetone, and distilled water for 5-10 minutes, and then put it into 75% ethanol solution, acetone, and distilled water for 5-10 minutes to remove the residual oil, dust and other impurities on the surface of the bracket, and then soak it in chromic acid lotion 10-20min, then thoroughly cleaned with distilled water for 20min by ultrasonic vibration, and then dried in a vacuum oven at 50°C for 24 hours.

[0035] (2) Take 2mg sz-21 powder and dissolve it in 1ml90% acetic acid solution, mix to make a drug solution, then weigh 20mg chitosan and dissolve it in the aforementioned 1ml dru...

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Abstract

The invention provides a nano-microcapsule coated intravascular stent of a core-shell structure and a preparation method of the nano-microcapsule coated intravascular stent, applicable to the technical field of medical instruments. Based on a coaxial electrostatic spraying technology which has characteristics of being efficient, simple and convenient, and having microspheres controlled to release and the like, a uniform nano-microcapsule coating is sprayed on a surface of a stent body part, namely the stent comprises a metal stent body part having an outer surface, having an excellent mechanical property; and a uniform drug coating, wherein the coating which is formed by uniformly depositing drug-loaded nano-microcapsules of core-shell structure, can encapsulate multiple drugs and has a good slow-release effect. The drug stent coating prepared by the invention is controllable in coating thickness, simple in preparation process, low in equipment requirement and high in preparation efficiency. Depending on curative effect of the required stent, variety of the encapsulated drugs, encapsulated drug dosage and encapsulation way can be changed to realize different release effects; and the intravascular stent is favorable for blood vessel endothelium repairing and inhibiting restenosis.

Description

technical field [0001] The invention relates to a core-shell structure nanoparticle-coated vascular stent and a preparation method thereof, in particular to a coaxial electrostatic spray coating preparation technology, and belongs to the technical field of medical devices. Background technique [0002] Atherosclerotic disease (AS) is a large class of cardiovascular diseases that seriously endanger human health. Percutaneous coronary intervention (PCI) for narrowed and completely occluded coronary arteries has become one of the most effective means of treating coronary heart disease. However, the incidence of in-stent restenosis with simple bare metal stent implantation is still high. Combining drugs with stents is an effective means to prevent restenosis in interventional therapy. Most of the vascular stents placed at present are drug-eluting vascular stents. Practice has proved that drug-eluting stents significantly reduce the incidence of restenosis. Drug-eluting stents...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/16
Inventor 王贵学杜若林尹铁英王亚洲饶琼
Owner CHONGQING UNIV
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