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Nano-metal oxide-minocycline nano sustained-release gel as well as preparation method and application thereof

A nano-metal and minocycline technology, which is applied in the field of treatment of acute and chronic periodontitis and gum disease, can solve the problems of milk precipitation, toxic substances, and particle size increase, so as to increase drug concentration, achieve good effect, and reduce toxicity. side effects

Active Publication Date: 2016-03-02
XUZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The carrier of the sustained-release agent contains ethanol, chloroform and polyethylene glycol. Its shortcoming is that polyethylene glycol is a synthetic polymer material, and it is easy to accumulate in human tissues after long-term use. Produce toxic substances; 2. Minocycline absorbable microspheres
Its shortcomings include: low drug encapsulation efficiency and drug loading; non-zero-order drug release due to microsphere shape and biodegradation in vivo; the drug has not been released in the most suitable time; Insufficient research on different release programs and speeds of drugs; 3. 2% minocycline gel
The storage stability of liquid liposomes is relatively poor, and it is prone to agglomeration, fusion and drug leakage. At the same time, liposomes are affected by temperature, light, etc. and will produce phenomena such as milking, coagulation, fusion and particle size increase. The application of liposomes has been greatly limited

Method used

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  • Nano-metal oxide-minocycline nano sustained-release gel as well as preparation method and application thereof
  • Nano-metal oxide-minocycline nano sustained-release gel as well as preparation method and application thereof
  • Nano-metal oxide-minocycline nano sustained-release gel as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Preparation of nano zinc oxide-minocycline albumin gel

[0023] 1. Preparation of nano-zinc oxide

[0024] Cetyltrimethylammonium bromide CTAB0.3644g, cyclohexane 10ml are placed in the reaction bottle, isopropanol IPA5ml is precisely added dropwise, and stirred at room temperature until a uniform milky white emulsion is formed; keep stirring, and slowly pour into the solution Add 1 mol / L zinc acetate aqueous solution dropwise until the solution system is instantly clear. 3000-4000rpm rotating and centrifuging to obtain nanometer zinc oxide particles, the particle size of which is kept at 20-200 nanometers.

[0025] 2. Preparation of Minocycline Buffer

[0026] Put the content of 100mg minocycline hydrochloride capsules in a 500mL beaker, add 200mL distilled water to dissolve, stir well, filter and get the clear liquid, adjust the pH value to 7.5 with methanol solution of sodium hydroxide, and get 50% concentration of minocycline solution.

[0027] Tak...

Embodiment 2

[0034] Embodiment 2: Preparation of nanometer silver oxide-minocycline albumin gel

[0035] 1. Preparation of nano-silver oxide

[0036] Add 0.3688g CTAB solid to a reaction flask containing 10mL each of 0.04mol / L NaOH solution and cyclohexane, stir at room temperature until the solid is completely dissolved, slowly add 0.04mol / L silver nitrate aqueous solution to the solution, stir at 40°C for 1h, and the solution There is dark brown turbidity generated. After the reaction, the product was centrifuged at 4000rpm with a low-speed auto-balancing centrifuge, and the product was washed three times with absolute ethanol and distilled water successively to remove residual ions and CTAB. The washed product was dried in a vacuum oven at 60°C for 1 day to obtain the final nano-silver oxide powder with a particle size of 70-100 nm, uniform particle size distribution and good dispersibility.

[0037] 2. Preparation of Minocycline Buffer

[0038] Put the content of 100mg minocycline hyd...

Embodiment 3

[0046] Embodiment 3: Preparation of nano-titanium oxide-minocycline albumin gel

[0047] 1. Preparation of nano-titanium oxide

[0048] Take 6g of titanium sulfate in a 1000mL volumetric flask, dissolve it with water and dilute to the mark to obtain a 0.05mol / L titanium sulfate solution. Take 1000 mL of 0.05 mol / L titanium sulfate solution and place it in a beaker, add 50 mL of 0.01 mol / L EDTA solution under stirring conditions, and after standing for a period of time, adjust it with sodium hydroxide solution (0.1 mol / L) The pH of the solution was adjusted until a white precipitate appeared. Heat the water bath to 80°C for 2 hours, and wash the precipitate until there is no sulfate ion. The washed product was dried in a vacuum oven at 150°C for 2 hours, and calcined in an infrared oven at 500°C for 2 hours to obtain the final nano-titanium oxide particles with a particle size of 40-100 nm, uniform particle size distribution, and dispersed sex is better.

[0049] 2. Prepara...

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Abstract

The invention discloses a nano-metal oxide-minocycline nano sustained-release gel as well as a preparation method and application thereof. In accordance with the current situations of a minocycline local preparation which is insufficient in drug release stability and effectiveness, and the like, the water-soluble gel sustained-release agent is prepared by covering active metal oxide nano molecules and minocycline hydroxide with a biodegradable high polymer material by taking carbomer as a substrate; the sustained-release agent is good in stability and good in moisture retention, and the sustained-release agent has the advantages of being capable of lowering drug content, enhancing an antibacterial effect and prolonging a drug action time, and being capable of achieving targeted localization, easy to operate, low in cost and the like; the sustained-release gel is more suitable for treating acute and chronic periodontal disease and gingivitis; and the sustained-release gel has good market and economic benefits.

Description

technical field [0001] The invention relates to clinical research on the synergistic effect of nanometer materials and antibacterial drugs, and is used for preparing dental medicines, especially for treating acute and chronic periodontitis and gum disease. Background technique [0002] Periodontal disease refers to a type of chronic, infectious, and destructive disease that invades the gums and periodontal supporting tissues. It has a high prevalence worldwide and is the main cause of tooth loss in adults. The pathogenesis of periodontal disease is complex, and it is generally believed that bacteria are the most critical factor leading to periodontal disease. At present, the main methods of periodontal disease treatment are curettage and root planing. Although these two methods can reduce the number of subgingival pathogenic bacteria, they cannot completely eliminate subgingival pathogenic bacteria. Bacteria will grow slowly and gradually return to pre-treatment levels. Si...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/51A61K31/65A61K47/48A61K47/32A61P1/02A61P31/04
Inventor 牟杰李程徐铭递陆建吾赵伯南周艺江相兰张彦卓裴冬生高军红
Owner XUZHOU MEDICAL COLLEGE
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