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Porous artificial bone and preparation method thereof

An artificial bone and pore size technology, applied in the field of biomedical materials, can solve the problems of insufficient hardness and toughness, low mechanical strength of artificial bone, and poor biocompatibility, so as to meet individual needs, facilitate repair, and promote Adhesion effect

Active Publication Date: 2016-04-13
胡军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The first purpose of the present invention is to provide a porous artificial bone, which solves the problems of low mechanical strength, poor plasticity and biocompatibility, hardness and toughness not up to the requirements, and inflammation after degradation of the existing artificial bone.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for preparing a porous artificial bone, mainly comprising the following steps:

[0035] (1) Preparation of MgSr-TCP powder by chemical precipitation method.

[0036] According to the molar ratio of Mg+Sr+Ca and P in MgSr-TCP is 1.45, the molar fraction of Mg is 1%, and the molar fraction of Sr is 0.5%, the previously prepared strontium nitrate solution, magnesium chloride solution and ammonium hydrogen phosphate solution are simultaneously Slowly add it to the calcium nitrate solution at 80°C, adjust the pH value to 7 with ammonia water under constant stirring, and react for 2 hours. The precipitate was roasted in a muffle furnace at 1050 °C and kept for 2 hours. The obtained sample was fully ground in an agate mortar, and then the nano-sized MgSr-TCP powder was sieved through a standard sieve and stored in a desiccator for later use.

[0037] (2) The MgSr-TCP honeycomb grid frame was prepared by 3D printing method.

[0038] ①Design the honeycomb grid frame: ...

Embodiment 2

[0049] A method for preparing a porous artificial bone, mainly comprising the following steps:

[0050] (1) Preparation of MgSr-TCP powder by chemical precipitation method.

[0051] According to the molar ratio of Mg+Sr+Ca and P in MgSr-TCP is 1.70; the molar fraction of Mg is 20%, and the molar fraction of Sr is 10%, the strontium nitrate solution, magnesium chloride solution and ammonium hydrogen phosphate solution prepared in advance are simultaneously Slowly add it to the calcium nitrate solution at 90°C, adjust the pH value to 8 with ammonia water under continuous stirring, and react for 3 hours. The precipitate was roasted in a muffle furnace at 1050 °C and kept for 2 hours. The obtained sample was fully ground in an agate mortar, and then the nano-sized MgSr-TCP powder was sieved through a standard sieve and stored in a desiccator for later use.

[0052] (2) The MgSr-TCP honeycomb grid frame was prepared by 3D printing method.

[0053] ①Design the honeycomb grid frame...

Embodiment 3

[0062] A method for preparing a porous artificial bone, mainly comprising the following steps:

[0063] (1) The MgSr-TCP honeycomb grid frame was prepared by 3D printing method.

[0064] ①Design the honeycomb grid frame: use computer to carry out CAD 3D solid drawing to design a 3D model of a honeycomb grid cylinder with a diameter of 10 mm and a height of 5 mm, convert it into an STL file, and then divide this model into grids and divide layer processing. The design of the frame can design honeycomb grid structure frames of different scales and shapes according to the needs, not limited to cylinders.

[0065] ②Generation of scanning trajectory: The three-dimensional model is sliced ​​in layers in the computer, and the model is converted into a series of two-dimensional plane graphics. For each plane graphics, the corresponding scanning trajectory is generated on the computer.

[0066] ③Preparation of MgSr-TCP honeycomb grid frame: fully mix the nano-sized β-TCP, MgO, SrO po...

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Abstract

The invention relates to a porous artificial bone and a preparation method thereof. The porous artificial bone is in a honeycomb mesh shape and mainly formed by combination of PLGA and MgSr-TCP, wherein a mole ratio of Mg+Sr+Ca to P in the MgSr-TCP is 1.45-1.70, a mole fraction of Mg in the MgSr-TCP is 1%-20%, and a mole fraction of Sr is 0.5%-10%. The preparation method includes: preparing a MgSr-TCP honeycomb mesh framework by 3D (three-dimensional) printing, and putting in a negative form prepared by quick formation; mixing and vibrating nanoscale sodium chloride particles and slurry containing PLGA, pouring into the honeycomb mesh framework under a negative pressure, and performing freeze drying for 24h to remove a solvent; soaking in deionized water, changing the water per 6h, and drying in a drying machine after 24h. The porous artificial bone is excellent in hardness and toughness and is biomechanically optimized; local acidity can be effectively neutralized after PLGA degradation, inflammation is alleviated, strength of the artificial bone is improved, degradation of the artificial bone is promoted, and adhesion and proliferation of osteoblasts are facilitated; the preparation method is simple, the framework can be designed into different shapes to meet individual demands, and high flexibility and high intelligence are realized.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a porous artificial bone and a preparation method thereof. Background technique [0002] In the field of orthopedics, bone defects due to severe trauma, bone tumors, osteomyelitis and other reasons are very common. At present, the commonly used bone repair materials include autogenous bone and metal prosthesis. However, the source of autogenous bone is limited, and it is not suitable for the repair of large-scale bone defects. On the other hand, allogeneic bone transplantation is also an effective method, but there are also problems such as rejection, contradiction between supply and demand, and virus and disease transmission, which also increases the trauma and pain of patients. However, metal prostheses have problems such as loosening and breaking. Therefore, the application of tissue engineering technology, the use of artificial bone made of biomaterials, and the replace...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/50A61L27/18A61L27/12A61F2/28B33Y50/00
CPCA61F2/28A61F2210/00A61F2240/001A61F2310/00A61F2310/00293A61L27/12A61L27/18A61L27/50A61L27/56A61L2400/18C08L67/04
Inventor 胡军卢晓林陈斌黄钟炼卢晓辉
Owner 胡军
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