Aliphatic polyester-nano hydroxyapatite composite material and preparation method thereof

A technology of nano-hydroxyapatite and aliphatic polyester, applied in medical science, prosthesis, etc., can solve the problems of difficulty in uniform dispersion of nano-HA, poor interface compatibility, etc., and achieve good biological and mechanical properties, conditions Mild, mechanical property-enhancing effect

Inactive Publication Date: 2016-08-03
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of aliphatic polyester-nanometer HA composite material and preparation method, it is characterized in that utilize dopamine oxidative self-polymerization to realize the surface coating modification to nano-HA, promote nano-HA and fat through polydopamine interfacial layer The interfacial bonding of aliphatic polyesters can achieve the purpose of improving the dispersion of nano-HA and increasing the amount of nano-HA added, so as to solve the problems of difficult uniform dispersion and poor interface compatibility of nano-HA in aliphatic polyesters, and obtain mechanical properties and biological properties. Excellent bone regeneration repair material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 (co-precipitation method+0.1mg / mL+72hr+10%wtHA+solution casting film+chloroform+PLLA)

[0021] (1) Take 4g of calcium nitrate tetrahydrate and 2g of ammonium dihydrogen phosphate, add them to 150mL of deionized water in turn, adjust the pH of the system to 10 with ammonia water, and react at 80°C for 2 hours while stirring. After the reaction, centrifugal separation, deionized water washing, vacuum drying to obtain HA nanorods;

[0022] (2) Take 1 g of HA nanorods, suspend and disperse them in 0.1 mg / mL dopamine solution, add tris to adjust the pH of the system to 8.5, and react at room temperature for 72 hours under stirring. After the reaction, centrifuge, wash with deionized water, and vacuum dry to obtain polydopamine-modified HA nanorods;

[0023] (3) Disperse 1 g of polydopamine-modified HA nanorods in chloroform, swell at room temperature for 24 hours to obtain suspension A; Polymer solution B; mix A and B evenly, and then cast solution at room temp...

Embodiment 2

[0024] Example 2 (co-precipitation method+2mg / mL+48hr+30%wtHA+solution casting film+chloroform+PLLA)

[0025] (1) step is the same as step (1) of embodiment 1;

[0026] (2) Take 1 g of HA nanorods, suspend and disperse them in a 2 mg / mL dopamine solution, add tris to adjust the pH of the system to 8.5, and react at room temperature for 48 hours while stirring. After the reaction, centrifuge, wash with deionized water, and vacuum dry to obtain polydopamine-modified HA nanorods;

[0027] (3) Disperse 3 g of polydopamine-modified HA nanorods in chloroform, swell at room temperature for 24 hours to obtain suspension A; dissolve 7 g of PLLA (molecular weight: 100,000) in chloroform, stir and dissolve at room temperature for 24 hours to obtain uniform polymer solution B; Mix A and B evenly, and then solution-cast at room temperature. After the solvent is completely volatilized, a PLLA / HA composite film with a HA nanorod content of 30%wt is obtained. Compared with the pure PLLA f...

Embodiment 3

[0028] Example 3 (hydrothermal method+2mg / mL+48hr+30%wtHA+solution casting film+chloroform+PLGA)

[0029] (1) Take 24g ethanol solution of oleic acid, 10mL NaOH aqueous solution, 10mL CaCl 2 Aqueous solution, 5mL NaH 2 PO 4 The aqueous solution was sequentially added into the beaker, and reacted at 180° C. for 24 hours in a hydrothermal reaction kettle. After the reaction, centrifugal separation, deionized water washing, vacuum drying to obtain HA nanofibers;

[0030] (2) Take 1 g of HA nanofibers, suspend and disperse them in a 2 mg / ml dopamine solution, add tris to adjust the pH of the system to 8.5, and react at room temperature for 48 hours while stirring. After the reaction, centrifugal separation, deionized water washing, vacuum drying to obtain polydopamine modified HA nanofibers;

[0031] (3) Disperse 3 g of polydopamine-modified HA nanofibers in chloroform, swell at room temperature for 24 hours to obtain suspension A; A homogeneous polymer solution B was obtai...

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Abstract

The invention belongs to the field of preparation of a nano composite material, and especially relates to an aliphatic polyester-nano hydroxyapatite composite material and a preparation method thereof. The preparation method comprises the following steps: 1) employing coprecipitation and a hydrothermal method or a sol-gel/static spinning method, synthesizing a hydroxy apatite nano rod or nano fiber, 2) realizing surface cladding modification on nano hydroxy apatite through dopamine oxidation auto-polymerization; and 3) employing a solution blending method, the aliphatic polyester/nano hydroxy apatite composite material film or a porous support can be prepared. The method has advantages of mild modification condition, simple operation, and obvious modification effect, the aliphatic polyester-coated hydroxy apatite is uniformly dispersed in an aliphatic polyester matrix, interface bonding property is improved, the mechanical properties of the aliphatic polyester-coated hydroxy apatite composite material is obviously improved, and the composite material can be used in relative filed of bone tissue regeneration restoration.

Description

Technical field [0001] The present invention is the preparation of nano composite materials and bone tissue regeneration, which involves a variety of fattene polyester-nano-hydroxypexylphygensn composite materials and preparation methods. Background technique [0002] Hydroxylhston otolite CA 10 (PO 4 Cure 6 (OH) 2 , Referred to as HA, is the main component of human bones and teeth.The artificial synthetic HA is very similar to the composition and the crystal structure in the biological hard tissue, and it has good bone transmission and bone induction.After the HA -porous stent is implanted in the body, it can effectively promote the regeneration of bone tissue.However, the disadvantages of simple HA brackets are also obvious, such as bionic abnormalities, poor stability of mechanical stability, and lack of bionics that lack the characteristics of organic / inorganic composite materials for natural cells.In recent years, the preparation technology of Nano HA has become more and mor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/56
Inventor 蔡晴孙洪阳杨小平艾淼易蜜何昆
Owner BEIJING UNIV OF CHEM TECH
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