Nano-fiber surface-modified xenogeneic acellular nerve graft and preparation method thereof
A surface modification, nanofiber technology, applied in fiber treatment, coating, medical science and other directions, can solve the problems of scar formation, affecting the surgical effect, unfavorable nerve connection, etc., to prevent tissue adhesion, firm bonding, and low price. Effect
Inactive Publication Date: 2017-06-30
YANTAI ZHENGHAI BIO TECH
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The invention discloses a nano-fiber surface-modified xenogeneic acellular nerve graft and a preparation method thereof. The nano-fiber surface-modified xenogeneic acellular nerve graft consists of an xenogeneic acellular nerve graft and a degradable polyester nano-fiber membrane adhered onto the surface of the xenogeneic acellular nerve graft, wherein the xenogeneic acellular nerve graft is an extracellular matrix obtained by performing acellular disposal on an isolated peripheral nerve of a healthy mammal. The nano-fiber surface-modified xenogeneic acellular nerve graft is extremely low in moisture content after freeze-drying treatment and stable in performance, and can realize no protection liquid and normal-temperature preservation after being sterilized and packaged. The nano-fiber surface-modified xenogeneic acellular nerve graft disclosed by the invention is wide in source, low in cost, free from immunogenicity, good in biocompatibility and safe to use; a microstructure of the peripheral nerve extracellular matrix is completely retained, and a natural pipeline bracket and a nutrition environment are provided for nerve axonal regeneration and nerve conduction function recovery.
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Property | Measurement | Unit |
Thickness | 0.01 ~ 0.5 | mm |
Mass volume concentration | 0.02 ~ 0.2 | g/ml |
Thickness | 0.07 | mm |
tensile | MPa | |
Particle size | Pa | |
strength | 10 |
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