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Improved preparation process of whole fermented oxytetracycline calcium

A preparation technology of oxytetracycline calcium, which is applied in the field of preparation of fully fermented oxytetracycline calcium, can solve the problems of increasing drying costs and waste, and achieve the effects of reducing materials, improving efficacy, and reducing costs

Active Publication Date: 2020-11-13
SHANDONG LUKANG SHELILE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Both of the above two processes mentioned that after adding calcium carbonate, acidification adjusts pH=4.5-6.5, and adding acid after adding calcium, it is inevitable that the acid and calcium will directly contact, react and consume each other; and in the process of adding acid, it will bring Add solvent water, and increase drying cost; And hydrochloric acid and the NH in the fermented liquid system 3 The salt produced by the reaction will decompose into the gas phase during the drying process and be wasted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Stop supplementing ammonia water at 160 hours in the late stage of fermentation, adjust the tank pressure to 0.15 MPa, and control the sugar normally. Fine-tune the amount of sugar supplement, ventilation and stirring according to OD and DO, stop supplementing sugar at 170 hours, keep the tank temperature at 31.0°C, and release the tank when pH=5.2. Obtain fermentation broth; take 10L of fermentation broth and directly add 1ml of polyether defoamer (10ml*10% concentration) for defoaming, add 400g of light calcium carbonate, turn on compressed air at 115ml / min to stir and blow for 1.5h, then add 5g of activated carbon and stir for 0.5 h, spray dry, sieve, cool down and pack to obtain 1.56kg of product, content 20.2%, moisture 3.0, heavy metal≤10ppm, arsenic≤5ppm. The test data of the fermentation broth at each time period are shown in Table 1.

[0027] The detection data of fermented liquid in each period of time in the embodiment 1 of table 1

[0028] project ...

Embodiment 2

[0030] This example is consistent with the post-fermentation control process in Example 1. In the pretreatment, take 10L of the fermentation broth in Example 1, directly add 1ml of organic silicon defoamer (10ml*10% concentration) for defoaming, and add 400g of light Calcium carbonate, turn on compressed air at 50ml / min, stir and blow for 75min, then add 50g of dried anthracite and stir for 1h, spray dry, sieve, cool down and pack to obtain 1.58kg of product, content 20.1%, moisture 3.0, heavy metal ≤ 10ppm, arsenic ≤ 5ppm .

Embodiment 3

[0032] Stop supplementing ammonia water at 160h in the late stage of fermentation, adjust the tank pressure to 0.13MPa, and control the sugar normally. Fine-tune the amount of sugar supplementation, ventilation and stirring according to OD and DO, stop supplementing sugar at 170h, keep the tank temperature at 31.0°C, and put the tank at pH=5.6 to obtain fermentation broth. Take 10L of fermentation broth and directly add 0.1ml of silicone defoamer (5ml*2% concentration) to defoam, add 400g of light calcium carbonate, turn on compressed air at 100ml / min, stir and blow for 1.5h, then add 20g of charcoal, stir for 1h, spray dry , sieved, cooled and packaged to obtain 1.55kg of product, content 19.8%, moisture 3.1, heavy metal ≤ 10ppm, arsenic ≤ 5ppm. The detection data of the fermentation broth in each time period are shown in Table 2.

[0033] In table 2 embodiment 3, each time period fermented liquid detects data

[0034] project 160h 170h 180h pH 5.79 5.68 ...

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PUM

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Abstract

The invention belongs to the technical field of biological extraction, and particularly relates to an improved full-fermentation oxytetracycline calcium preparation process. The process comprises the following steps: stopping filling ammonia water after fermenting for 160 hours; adjusting the tank pressure to 0.02MPa or less; stopping filling sugar after 170 hours; finally controlling the discharge tank pH=5.2-5.6; obtaining fermentation broth; adding defoaming agent to the fermentation broth for defoaming; then adding light calcium carbonate and stirring for 1-1.5 h; inducing compressed air for wind blowing in the stirring process; adding heat source adsorbent after stirring, and then stirring again for 0.5-1.5 h to obtain bacteria slurry; treating the obtained bacteria slurry to obtain qualified oxytetracycline calcium. According to the process, the fermentation broth pH is controlled by using the post-fermentation process; ammonia nitrogen is reduced by using the wind blowing method; the direct contact between acid and calcium in the pretreatment process is avoided; the water entrainment in the acidification process is avoided; the material consumption and the power consumption are reduced; the production cost is reduced; the side effects of finished products can be reduced by adding the heat source adsorbent; the product efficacy is improved.

Description

technical field [0001] The invention belongs to the technical field of biological extraction, and in particular relates to an improved preparation process of fully fermented oxytetracycline calcium. Background technique [0002] Oxytetracycline is a kind of tetracycline antibiotics. It has antibacterial effect on most Gram-positive bacteria, negative bacteria, cocci and bacilli, and also has inhibitory effect on Rickettsia and amoeba pathogens. It is widely added to pigs and chickens. , cattle, etc. to promote growth and prevent disease. [0003] The production process of oxytetracycline base is generally purified with zinc sulfate and yellow blood salt, 122 cation resin exchange decolorization, and crystallization of ammonia water. And its solid-liquid separation process obtains a high protein content in the slag, and the side effect of oxytetracycline is low, so it can generally be considered as a valuable by-product. Resin acid-base regeneration treatment wastewater and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P29/00
CPCC12P29/00
Inventor 廖韦红姚福元孙庆柱黄曙光郑向伟曹淳美
Owner SHANDONG LUKANG SHELILE PHARMA