A kind of transdermal delivery system of terbinafine hydrochloride long-acting film spray

A technology of terbinafine hydrochloride and terbinafine, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, skin diseases, etc., and can solve the problem of short residence time, easy to be stained by socks, underwear, etc. And other problems such as friction, to achieve good film-forming performance, good tensile strength, and promote the effect of granulation re-growth

Active Publication Date: 2021-04-06
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When sprayed on the lesion, these conventional preparations stay in the lesion for a short time and are easily rubbed off by socks, underwear, etc. In order to achieve the desired therapeutic effect, repeated administration is required

Method used

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  • A kind of transdermal delivery system of terbinafine hydrochloride long-acting film spray
  • A kind of transdermal delivery system of terbinafine hydrochloride long-acting film spray
  • A kind of transdermal delivery system of terbinafine hydrochloride long-acting film spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068]

[0069] Step 1: Add 0.1g chitosan oligosaccharide-3kDa into purified water, stir to dissolve, and form chitosan oligosaccharide solution for later use; add 0.02g terbinaol hydrochloride and 0.1g poloxamer 188 to 5mL methanol, stir to dissolve , into a drug-loaded organic solution for later use. Fully mix the chitosan solution and the drug-loaded organic solution, continue to stir for 30 minutes to 60 minutes, remove the organic reagent by rotary evaporation under reduced pressure, then add triethyl citrate, stir and dissolve, which is the "water phase".

[0070] Step 2: Add 0.2 g of ethyl cellulose with a viscosity of 7 cp into 5 mL of ethyl acetate and stir to dissolve, which is the "oil phase".

[0071] Step 3: Fully mix the "water phase" and "oil phase", stir magnetically for 30-60 minutes to form colostrum, 600W probe ultrasonic 10min to form end-milk, remove organic reagents by rotary evaporation under reduced pressure, add 0.02g of simethicone , add water to ...

Embodiment 2

[0073]

[0074] Step 1: Add 0.2 g of terbinaphol hydrochloride and 0.6 g of poloxamer 407 into 10 mL of methanol, stir to dissolve, and form a drug-loaded organic solution for later use. Slowly add 40mL of purified water into it dropwise, continue to stir for 30min-60min, remove the organic reagent by rotary evaporation under reduced pressure, and obtain a drug-loaded aqueous solution, add 0.4g of chitosan oligosaccharide-5kDa, stir and dissolve, which is the "water phase".

[0075] Step 2: Add 0.8 g of ethyl cellulose with a viscosity of 10 cp into 10 mL of chloroform, stir to dissolve, add 0.2 g of tributyl citrate, stir to dissolve each other, which is the "oil phase".

[0076] Step 3: Fully mix the "water phase" and "oil phase", stir magnetically for 40-80 minutes to form colostrum, 300W probe ultrasonic for 15 minutes to form end-milk, remove organic reagents by rotary evaporation under reduced pressure, and add 0.12g of silicon dioxide Simethicone, add water to make u...

Embodiment 3

[0078]

[0079] Step 1: Add 0.24 g of terbinaphol, 0.96 g of poloxamer 188 (F68) and sodium dodecyl sulfate (SDS) into 8 mL of ethanol, stir and dissolve to form a drug-loaded organic solution, and set aside. Slowly add 30mL of purified water dropwise, continue to stir for 30min~80min, remove the organic reagent by rotary evaporation under reduced pressure, and obtain the drug-loaded aqueous solution, add 0.45g of carboxymethyl chitooligosaccharide-9kDa, stir and dissolve, which is the "water phase" .

[0080] Step 2: Add 0.3 g of ethyl cellulose with a viscosity of 20 cps into 7 mL of petroleum ether, stir to dissolve, add 0.15 g of glycerol triacetate, stir to dissolve each other, which is the "oil phase".

[0081] Step 3: Fully mix the "water phase" and "oil phase", stir magnetically for 50-90 minutes to form colostrum, 400W probe to sonicate for 15 minutes to form end-milk, remove organic reagents by rotary evaporation under reduced pressure, add 0.12g of simethicone, ...

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and discloses a transdermal delivery system for long-acting treatment of skin fungal infections: terbinafine hydrochloride long-acting spray film agent, and particularly provides a water-soluble stable system of terbinafine hydrochloride method of preparation. The terbinaphthol hydrochloride long-acting spray film is characterized in that it can form a true film when it is sprayed on the skin surface, prolongs the maintenance time of the preparation on the skin, and can make the medicine slowly release on the skin, and acts and stores in the skin. Focus, to achieve long-term treatment of skin fungal infection.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and provides a transdermal delivery system for long-acting treatment of skin fungal infections: terbinafine hydrochloride long-acting spray film agent, especially provides a preparation of a water-based stable system of terbinafine hydrochloride method Background technique [0002] In recent years, due to the wide application of cytotoxic drugs, immunosuppressants, broad-spectrum antibiotics, etc., the development of surgical methods such as organ transplantation, interventional therapy, and intubation techniques, the incidence of serious diseases such as blood diseases, geriatric diseases, and tumors has continued to rise, making fungal infections The incidence rate and pathogenic bacteria are all increasing year by year. Fungi, which are conditional pathogenic bacteria for the human body, may cause systemic or local fungal infections when the body's resistance is reduced an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/137A61K47/38A61P17/00A61P31/10A61P17/18
Inventor 姚静丁宇吴莹贾颖君张艳慧
Owner CHINA PHARM UNIV
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