Applications of bovine bone peptide in preparation of drugs and food for treating and preventing osteoporosis

A technology of osteoporosis and bovine bone, which is applied in the field of health food, can solve the problems of increasing the incidence of breast cancer, venous thrombosis, myocardial infarction, adverse hormone reactions, etc., and achieve the effect of overcoming low immune function and less toxic side effects

Inactive Publication Date: 2018-05-25
亿菩升(上海)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of osteoporosis in postmenopausal women mainly adopts hormone replacement therapy based on estrogen and progesterone, but long-term

Method used

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  • Applications of bovine bone peptide in preparation of drugs and food for treating and preventing osteoporosis
  • Applications of bovine bone peptide in preparation of drugs and food for treating and preventing osteoporosis
  • Applications of bovine bone peptide in preparation of drugs and food for treating and preventing osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The construction of embodiment 1 osteoporosis animal model and oral administration experiment

[0041] 2.1. Experimental reagents and instruments

[0042] Bovine bone peptide (provided by Hubei Ruibang Biotechnology Co., Ltd.); chondroitin sulfate (provided by Hubei Ruibang Biotechnology Co., Ltd.); positron emission tomography / X-ray computed tomography instrument (model Inveon PET / CT); Scanning electron microscope (model JEOL6390LV); Zwick material testing machine (model B22.5 / TS1S, produced in Zwick / Roell Group, Germany); electronic balance (model YP1201N); alkaline phosphatase activity assay kit (purchased from Biyuntian Company) ; Anti-tartrate acid phosphatase kit (purchased from Biyuntian Company); blood calcium kit (purchased from Qiyi Biotechnology Co., Ltd.); blood phosphorus kit (purchased from Qiyi Biotechnology Co., Ltd.); Osteocalcin ELISA kit (purchased from Cloud-Clone Corp company)

[0043] 2.2. Construction of osteoporosis animal model and drug regime...

Embodiment 2

[0069] Embodiment 2 grouping experimental results

[0070] 18 rats were randomly divided into 6 groups, 3 rats in each group, see Table 1. After intraperitoneal injection of 350 mg / kg chloral hydrate anesthetized, fixed on the operating table in prone position, opened 1.5 cm beside the posterior midline of the back, centered at 1.5 cm below the bilateral costal margins, and used a razor with a radius of 1.5 cm Hair was shaved and alcohol was sprayed for disinfection. A longitudinal incision about 1-1.5 cm in length was made with surgical scissors on the back at 1.5 cm below the posterior edge of the costa and 1.5 cm beside the posterior midline, and the skin and subcutaneous tissue were cut in sequence. Open the peritoneum, enter the abdominal cavity, remove the surrounding fatty tissue, pull the ovary out with forceps, remove the ovary after ligation at the junction of the ovary and the uterus, check whether the hemostasis is complete, and then return it to the abdominal cavi...

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Abstract

The invention discloses applications of bovine bone peptide in preparation of drugs and food for treating and preventing osteoporosis, wherein the drugs and the food are particularly suitable for postmenopausal women. According to the present invention, the new applications of the bovine bone peptide are found by constructing osteoporosis animal models, wherein the osteoporosis treatment and prevention drugs and the osteoporosis treatment and prevention food prepared from the bovine bone peptide are safe, effective and reliable compared to hormones.

Description

technical field [0001] The invention relates to the field of health food, in particular to the application of bovine bone peptide. Background technique [0002] Osteoporosis (Osteoporosis, OP) is a systemic bone disease that decreases bone density and destroys bone microstructure due to various reasons, resulting in increased bone fragility and prone to fractures. Decreased estrogen levels may lead to the occurrence of osteoporosis. In the process of bone remodeling, bone resorption is greater than bone formation, resulting in bone loss, which eventually leads to decreased bone mass, destruction of bone tissue microstructure, decreased bone strength, and increased bone fragility. prone to fractures. [0003] According to statistics from the World Health Organization (WHO), osteoporosis has become a global health problem. At present, about 200 million people in the world suffer from osteoporosis, and the incidence of osteoporosis ranks seventh among chronic diseases. Among ...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K35/32A61P19/10A23L33/18
CPCA23V2002/00A61K35/32A61K38/012A23V2200/306
Inventor 尹晓清莫炜吴海尹中夏
Owner 亿菩升(上海)生物科技有限公司
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