Degradable (P3/4HB-PCL)-PU medical biliary stent material and preparation method thereof

A stent material, -PU technology, used in medical science, surgery and other directions, can solve the problems of high cost of metal stents, inability to provide radial support for the bile duct, no degradability, etc., and achieve good biocompatibility and degradability. The effect of preventing benign biliary stricture and biliary sludge deposition
CN109701092AActive Publication Date: 2019-05-03THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
Publication Date
2019-05-03

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Abstract

The present invention discloses a degradable (P3 / 4HB-PCL)-PU medical biliary stent material and a preparation method thereof. The material comprises polytetrahydrofuran ether diol (PTMG), hydroxyl terminated polylactic acid (PLA-OH), hexamethylene diisocyanate (HDI), poly-epsilon-caprolactone (PCL), poly 3-hydroxybutyrate-4-hydroxybutyrate (P3 / 4HB), paclitaxel, lactic acid, non-toxic catalysts, dichloromethane, catalysts and a chain extender. The method comprises the following steps: (1) lactic acid impurity removal; (2) hydroxy-terminated polylactic acid synthesis by direct condensation polymerization; (3) degradable polyurethane medical elastomer synthesis; and (4) degradable (P3 / 4HB-PCL)-PU medical biliary stent material preparation. The degradable TAXOL-(P3 / 4HB-PCL)-PU nano-biliary stent is formed by a special soluble core-shaft-assisted coaxial electrospinning technology. The stent has biocompatibility, safety, drug controlled release and benign biliary stricture prevention effect.
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Description

technical field

[0001] The invention relates to a medical biliary tract stent material, in particular to a degradable (P3 / 4HB-PCL)-PU medical biliary tract stent material capable of providing biliary tract radial support force with better elasticity and excellent mechanical properties and a preparation method thereof. Background technique

[0002] The biliary system has the functions of releasing, storing, concentrating and emptying bile, and plays an important role in controlling the reaction of bile entering the duodenum and food. The method for treating malignant biliary obstruction caused by malignant tumors such as cholangiocarcinoma, liver cancer, pancreatic cancer and metastatic cancer (the disease has a high incidence rate, and it is often already at an advanced stage when it is detected) is a biliary stent. The specific operation is to implant a biliary stent into the narrowed or blocked bile duct, so that the blocked bile duct can be dredged. In recent years, with...

Claims

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