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A composition with the effect of preventing and treating complications of dialysis patients, its preparation method and its application

A composition and complication technology, applied in the field of biomedicine, can solve the problems of increased preparation process complexity and production costs, hyperkalemia complications, frequent use, etc., to avoid complications or adverse reactions, control blood sugar levels, The effect of improving nutritional status

Active Publication Date: 2020-09-18
麦孚营养科技(北京)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 5. Anemia
But there are following defects: the one, chestnut powder has increased the complexity of preparation technology and production cost; Complications of blood potassium; third, the composition and proportion of nutrients do not meet the requirements of guidelines for kidney disease, making it difficult to comprehensively improve protein energy deficiency, hyperphosphatemia, hyperkalemia, renal hypertension, and postdialysis hypotension in dialysis patients , anemia and other complications
[0017] In summary, the nutritional protein powder disclosed in the prior art for patients with kidney disease and dialysis has many defects: (1) The product mostly uses soybean protein as a raw material, and lacks the high purity, reasonable amino acid composition, high absorption, and high growth rate of whey protein concentrate. (2) Most of the products contain fructooligosaccharides, inulin, chestnut powder, etc., and the protein and energy composition ratio of the composition is difficult to meet the clinical needs of dialysis patients. Its comprehensive effect on improving the complications of dialysis patients is not good; (3) frequent use increases the treatment cost of patients and increases the burden of medical insurance, and the patient consumes a large amount of water, which increases the burden on the kidneys of patients with kidney disease and increases the risk of severe kidney disease
(4) Existing products or methods for improving complications of renal dialysis patients mostly use drugs or nutritional supplements to improve a certain complication of dialysis patients, and their comprehensive effect on improving dialysis complications is very limited

Method used

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  • A composition with the effect of preventing and treating complications of dialysis patients, its preparation method and its application
  • A composition with the effect of preventing and treating complications of dialysis patients, its preparation method and its application
  • A composition with the effect of preventing and treating complications of dialysis patients, its preparation method and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Example 1 Composition and proportioning research of the composition of the present invention

[0116] Weigh the required amount of raw materials according to Table 1, and mix them uniformly with a mixer to prepare compositions A-R. According to the method described in the present invention, the protein and energy content of the composition A-R is measured, and the blood phosphorus content is detected by the phosphomolybdic acid method, and the blood potassium content is detected by the ion selective electrode method, and the protein energy supply ratio is 10-20%. 7 Group compositions A, B, C, D, J, K, M.

[0117] 140 subjects were selected from patients with kidney disease who underwent hemodialysis three times a week for more than 3 months, and the subjects were aged 32-68 years. 140 patients were randomly divided into 7 groups, 20 cases in each group, there was no significant difference in age, etiology, course of disease, dialysis program, nutritional status, etc. ...

Embodiment 2

[0126] Example 2 Preparation of the composition of the present invention The components and proportions of the compositions 1-3 of the present invention are shown in Table 3.

[0127] Table 3 Components and proportioning ratio of compositions 1-3 of the present invention

[0128] Numbering Whey protein (g) Casein (g) Maltodextrin (g) corn syrup (g) Sunflower oil (g) Composition 1 15 15 15 4 51 Composition 2 23 5 35 6 31 Composition 3 23 5 25 4 43

[0129] Note: The composition of casein (g) used in Table 3 is sodium caseinate: calcium caseinate with a mass ratio of 1:3.5.

[0130] The preparation method of the composition 1-3 of the present invention: take the required amount of whey protein, sodium caseinate, calcium caseinate, maltodextrin, corn syrup and sunflower oil according to Table 3, and mix them evenly with a mixer , that is.

Embodiment 3

[0131] Example 3 Composition of the present invention is used to treat complications of chronic renal failure dialysis patients

[0132] 1. Test patients

[0133] 120 patients with nephropathy who underwent hemodialysis three times a week and had hemodialysis for more than 3 months were selected as test patients. There were 23 cases of episodic glomerulonephritis, 5 cases of hypertensive benign arteriolar nephrosclerosis, 4 cases of aristolochic acid nephropathy and 2 cases of unknown etiology. Among the 120 tested patients, 76% were mildly or moderately malnourished, and 24% were severely malnourished.

[0134] 2. Experimental method

[0135] Each group of patients in the test received treatment guidance, and corresponding symptomatic treatment was given according to the specific conditions of the test patients, including anti-infection, blood sugar control, blood pressure control, and anemia correction. The test patients continued to take the composition of the present ...

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PUM

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Abstract

The invention provides a composition with the effect of preventing and treating complications of dialysis patients, its preparation method and its application. The composition contains 5-33 parts of whey protein, 1-20 parts of casein or its salt, 1-20 parts of maltodextrin ‑50 parts, 1‑10 parts of corn syrup, 5‑75 parts of sunflower oil, can control the blood potassium level to less than 5.0mmol / L, control the blood phosphorus level to less than 1.78mmol / L, comprehensively improve dialysis patients Protein malnutrition, hyperphosphatemia, hyperkalemia, hypertension and other complications, prolong the dialysis interval of dialysis patients, and reduce the harm of dialysis to the body. In addition, each unit dose is prepared with 60mL of water to reduce the burden of fluid intake, equivalent to the osmotic pressure of the human body, better gastrointestinal tolerance, and higher patient compliance.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a composition capable of preventing and treating complications of dialysis patients, a preparation method thereof and an application thereof. Background technique [0002] Dialysis therapy uses hemodialysis and / or peritoneal dialysis to excrete components (such as solutes or water, etc.) in the body fluid of the dialysis patient through a semipermeable membrane. Hemodialysis uses the principle of semi-permeable membranes to expel various harmful metabolites and excess electrolytes from the body through diffusion, purify the patient's blood, correct water, electrolyte and acid-base balance, etc. Peritoneal dialysis uses the peritoneum as a semi-permeable membrane, uses gravity to pour the prepared dialysate into the patient's peritoneal cavity through the catheter, and then constantly replaces the peritoneal dialysate to remove metabolites and toxic substances in the body an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61P3/12A61P7/06A61P7/08A61P9/02A61P9/12A61K36/28A61K31/718
CPCA61K31/718A61K36/28A61K38/1709A61P3/12A61P7/06A61P7/08A61P9/02A61P9/12A61K2300/00
Inventor 郭伟
Owner 麦孚营养科技(北京)有限公司
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