Calcium phosphate bone cement with hollow through structure, preparation method and application thereof

A technology of calcium phosphate bone cement and calcium phosphate powder, which is applied in the field of preparation and has a hollow through-structure calcium phosphate bone cement, can solve the problems of early formation of unfavorable blood vessels, insufficient material strength, clinical application limitations, etc., and achieves good biocompatibility and biodegradability, facilitates formation and growth, facilitates transport and gas exchange

Active Publication Date: 2019-12-06
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the pores in the CPC solidified body are mostly sub-micron and nano-sized pores, and there is a lack of connected large pores above 100 μm, the new bone tissue only crawls and replaces on the surface of the CPC, which is not conducive to the growth of new bone tissue into the material, and is also not conducive to the formation of blood vessels. It is formed early and will cause the material to degrade slowly. The degradation time is usually more than one year, and some even exceed two years, resulting in a longer bone defect repair process.
As a result, the effect of bone repair is affected, and its clinical application is limited.
[0006] However, although calcium phosphate bone cement can form a microporous structure as a scaffold for bone tissue engineering applications, the p

Method used

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Examples

Experimental program
Comparison scheme
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Example Embodiment

[0037] Example 1

[0038] Preparation of fibrin fibers:

[0039] Weigh 450 mg of human fibrinogen, dissolve it in 2.25 ml of hexafluoroisopropanol solution, stir magnetically for 30 minutes, add 0.25 ml of normal saline, and stir for 10 minutes to obtain an 18% fibrinogen solution;

[0040] The fibrinogen solution was subjected to high-voltage electrostatic spinning, the voltage was set to 15kV, the spinning rate was 1.0 ml / h, and the electrospun fiber was received by a metal carrier. After 2.5 hours, the electrospun fibrin was obtained, and the fiber was cut into fibers with a length of 0.5mm Protein fiber.

Example Embodiment

[0041] Example 2

[0042] As an embodiment of the calcium phosphate cement of the present invention, the calcium phosphate cement of the present embodiment includes a solid phase powder and a solidification liquid;

[0043] 70 parts by weight of the absorbable fiber PLGA and 30 parts by weight of the fibrin fiber are uniformly mixed to form a mixed fiber. The absorbable fiber PLGA has a length of 0.5 mm and a diameter of 100 microns, and the length of the fibrin fiber is 0.5 mm. Mix 95% mass fraction of a-calcium phosphate powder with 5% mass fraction mixed fiber, and prepare the bone cement into a paste according to the amount of 0.3g liquid phase solidification liquid added to each gram of solid phase; where solidification liquid is mass fraction 4% Na 2 HPO 4 Solution.

Example Embodiment

[0044] Example 3

[0045] As an embodiment of the calcium phosphate cement of the present invention, the calcium phosphate cement of the present embodiment includes a solid phase powder and a solidification liquid;

[0046] 80 parts by weight of the absorbable fiber PLGA and 20 parts by weight of the fibrin fiber are uniformly mixed to form a mixed fiber, the length of the absorbable fiber PLGA is 1 mm, the diameter is 250 microns, and the length of the fibrin fiber is 0.5 mm. Mix 85% mass fraction of a-calcium phosphate powder with 15% mass fraction mixed fiber, and prepare the bone cement into a paste according to the amount of 0.5g liquid phase solidification liquid added to each gram of solid phase; where solidification liquid is mass fraction 4% Na 2 HPO 4 Solution.

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Abstract

The invention discloses a calcium phosphate bone cement with a hollow through structure, a preparation method and an application thereof, belongs to the technical field of calcium phosphate bone cement, wherein the calcium phosphate bone cement with a hollow through structure comprises a solid phase and a solidifying liquid, the solid phase comprises calcium phosphate powder and a fiber mixture, the fiber mixture is an absorbable fiber and a fibrin fiber, and the diameter of the absorbable fiber is 100-500mum, the length is 0.5 mm-1.5 mm, preferably, that diameter of the absorbable fiber is 200-400mum. The prepared calcium phosphate bone cement can form three-dimensional connected macropores, promote cell adhesion and proliferation, and improve the mechanical strength of the bone cement.

Description

technical field [0001] The invention relates to the technical field of calcium phosphate bone cement, in particular to a calcium phosphate bone cement with a hollow through structure, a preparation method and an application thereof. Background technique [0002] Calcium Phosphate Cement (CPC) was successfully developed by Borwn and Chow in the 1990s. It is a self-curing non-ceramic hydroxyapatite artificial bone material. It is composed of solid phase powder and solidification liquid mixed according to a certain ratio to form an easy-to-shape slurry, which solidifies itself in a short time, and the final hydration product is apatite, which is similar to the inorganic composition and crystal structure of human bone tissue. . CPC has good osteoconductivity and biocompatibility. [0003] Polylactic-co-glycolic acid (PLGA) is a high ester polymer obtained by the copolymerization of lactide (LA) and glycolide (GA), which has good biocompatibility, complete For a long time, it ...

Claims

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Application Information

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IPC IPC(8): C04B28/34C04B38/00D01F4/00A61L27/12A61L27/56C04B111/40
CPCC04B28/344C04B38/0022C04B38/0003A61L27/12A61L27/56D01F4/00C04B2111/00836C04B2111/40C04B16/06C04B16/0675
Inventor 车七石单玲星刘少辉张俊辉赵澎
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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