Calcium phosphate bone cement with hollow through structure, preparation method and application thereof

Abstract

The invention discloses a calcium phosphate bone cement with a hollow through structure, a preparation method and an application thereof, belongs to the technical field of calcium phosphate bone cement, wherein the calcium phosphate bone cement with a hollow through structure comprises a solid phase and a solidifying liquid, the solid phase comprises calcium phosphate powder and a fiber mixture, the fiber mixture is an absorbable fiber and a fibrin fiber, and the diameter of the absorbable fiber is 100-500mum, the length is 0.5 mm-1.5 mm, preferably, that diameter of the absorbable fiber is 200-400mum. The prepared calcium phosphate bone cement can form three-dimensional connected macropores, promote cell adhesion and proliferation, and improve the mechanical strength of the bone cement.

Description

technical field [0001] The invention relates to the technical field of calcium phosphate bone cement, in particular to a calcium phosphate bone cement with a hollow through structure, a preparation method and an application thereof. Background technique [0002] Calcium Phosphate Cement (CPC) was successfully developed by Borwn and Chow in the 1990s. It is a self-curing non-ceramic hydroxyapatite artificial bone material. It is composed of solid phase powder and solidification liquid mixed according to a certain ratio to form an easy-to-shape slurry, which solidifies itself in a short time, and the final hydration product is apatite, which is similar to the inorganic composition and crystal structure of human bone tissue. . CPC has good osteoconductivity and biocompatibility. [0003] Polylactic-co-glycolic acid (PLGA) is a high ester polymer obtained by the copolymerization of lactide (LA) and glycolide (GA), which has good biocompatibility, complete For a long time, it ...

AI Technical Summary

Problems solved by technology

[0005] Since the pores in the CPC solidified body are mostly sub-micron and nano-sized pores, and there is a lack of connected large pores above 100 μm, the new bone tissue only crawls and replaces on the surface of the CPC, which is not conducive to the growth of new bone tissue into the material, and is also not conducive to the formation of blood vessels. It is formed early and will cause the material to degrade slowly. The degradation time is usually more than one year, and some even exceed two years, resulting in a longer bone defect repair process.

As a result, the effect of bone repair is affected, and its clinical application is limited.

[0006] However, although calcium phosphate bone cement can form a microporous structure as a scaffold for bone tissue engineering applications, the pore size and connectivity of the pores cannot meet clinical requirements, and the material strength is insufficient.

[0007] Patent CN107881650A A method and application of coaxial double-layer electrospinning to prepare nanofiber membrane with core / shell embedding structure discloses the use of coaxial double-layer electrospinning technology to prepare nanofibers. Protein encapsulation, the degradation of fibrin requires the participation of plasmin. The degradation process is that the shell layer in the nanofiber is degraded first, and the core layer is exposed. Therefore, the internal polymer material degrades later than fibrin. This material is applied in bone cement It needs fibrin to degrade the polymer material of the core layer to degrade, which is not conducive to the growth of cells