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Paracetamol, caffein, artificial cow-bezoar and chlorphenamine maleate capsule and preparation method thereof

The technology of Kahuangmin capsule and caffeine is applied in the field of aminocahuangmin capsule and its preparation, which can solve the problems of poor bioavailability of aminocahuangmin capsule, high frequency of taking medicine, short duration of drug effect, etc. The effect of action time, drug effect time is long, and uniformity is good.

Pending Publication Date: 2020-04-14
江西杏林白马药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The Ankahuangmin Capsules prepared by the prior art still have the disadvantages of poor bioavailability in small doses and slow onset of action, and short duration of drug effect and high frequency of medication in large doses.

Method used

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  • Paracetamol, caffein, artificial cow-bezoar and chlorphenamine maleate capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Anka Huangmin capsules, by weight, its content includes the following components:

[0024] 70 parts of paracetamol, 2 parts of caffeine, 0.5 parts of chlorpheniramine maleate, 2 parts of artificial bezoar, 4 parts of filler, 2 parts of adhesive, 5 parts of sustained release agent, and 2 parts of lubricant.

[0025] Wherein the filler is a mixture of microcrystalline cellulose, lactose and starch;

[0026] Wherein binder is sodium carboxymethyl cellulose;

[0027] Wherein the sustained-release agent is ethyl cellulose;

[0028] Wherein the lubricant is a mixture of talcum powder and magnesium stearate.

[0029] Preparation method, concrete steps include:

[0030] S1. Weighing para-acetylaminophenol, caffeine, chlorpheniramine maleate and artificial bezoar in proportion and then micronizing them;

[0031] S2. Add filler and binder to the micropowder prepared in S1, add water with 5-10% of the mass of the micropowder, and wet granulate;

[0032] S3. The wet granules a...

Embodiment 2

[0037] Anka Huangmin capsules, by weight, its content includes the following components:

[0038] 75 parts of acetaminophen, 3 parts of caffeine, 1 part of chlorpheniramine maleate, 3 parts of artificial bezoar, 5 parts of filler, 2 parts of adhesive, 5 parts of sustained release agent, and 1 part of lubricant.

[0039] Wherein the filler is one or more of pregelatinized starch, mannitol, calcium hydrogen phosphate, calcium dihydrogen phosphate;

[0040] Wherein the binder is one or more of sodium carboxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinylpyrrolidone;

[0041] Wherein the sustained-release agent is one or both of ethyl cellulose, ethylene-vinyl acetate copolymer, and polymethacrylate;

[0042] Wherein the lubricant is one or both of micropowder silica gel and sodium stearate fumarate.

[0043] Preparation method, concrete steps include:

[0044] S1. Weighing para-acetylaminophenol, caffeine, chlorpheniramine maleate and artificial bezoar i...

Embodiment 3

[0051] Anka Huangmin capsules, by weight, its content includes the following components:

[0052] 80 parts of paracetamol, 5 parts of caffeine, 1 part of chlorpheniramine maleate, 3 parts of artificial bezoar, 6 parts of filler, 3 parts of adhesive, 6 parts of sustained release agent, and 3 parts of lubricant.

[0053] Wherein the filler is one or more of microcrystalline cellulose, lactose, starch, pregelatinized starch, mannitol, calcium hydrogen phosphate, and calcium dihydrogen phosphate;

[0054] Wherein the binder is one or more of sodium carboxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinylpyrrolidone;

[0055] Wherein the sustained-release agent is one or more of ethyl cellulose, ethylene-vinyl acetate copolymer, polymethacrylate;

[0056] Wherein the lubricant is one or more of talcum powder, magnesium stearate, micropowder silica gel and sodium stearate fumarate.

[0057] Preparation method, concrete steps include:

[0058] S1. Weighing par...

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Abstract

Belonging to the technical field of medicinal preparations, the invention provides a paracetamol, caffein, artificial cow-bezoar and chlorphenamine maleate capsule and a preparation method thereof. The preparation method specifically includes the steps of: S1, weighing paracetamol, caffein, chlorpheniramine maleate and artificial cow-bezoar in proportion, performing mixing, and then conducting micronizing treatment; S2, adding filler and an adhesive into the micropowder obtained in S1, adding water, and performing wet granulation; S3, feeding the wet granules into a fluidized bed for drying; S4, sieving the dried granules with a 10-16mesh sieve, straightening the granules, and adding a sustained-release agent by spray drying coating method; S5, adding a lubricant, and mixing the substancesuniformly; and S6, filling capsules and performing packaging. By adding the sustained-release agent, the effects of controlling the dissolution rate and prolonging the drug action time so as to improve the curative effect of the product can be achieved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an Ankahuangmin capsule and a preparation method thereof. Background technique [0002] Aminoka Huangmin is a common cold medicine, and its active ingredients are acetaminophen, caffeine, chlorpheniramine maleate, and artificial bezoar. Acetaminophen has analgesic and antipyretic effects. It produces analgesic effects by inhibiting the synthesis of prostaglandins in the central nervous system and blocking the impulse of pain-sensing nerve endings. It produces peripheral blood vessel dilation, sweating and heat dissipation through the hypothalamic thermoregulation center To achieve the antipyretic effect. Caffeine (in small doses) acts on the nerve center of the cerebral cortex to excite the spirit, relieve fatigue, constrict cerebral blood vessels, and relieve the permeability caused by dilation of cerebral blood vessels. Chlorpheniramine maleate is an antih...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/48A61P11/00A61P29/00A61K31/167A61K31/522A61K31/4402
CPCA61K31/167A61K31/522A61K31/4402A61K35/413A61K9/1652A61K9/1623A61P11/00A61P29/00A61K2300/00
Inventor 胡志文
Owner 江西杏林白马药业股份有限公司
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