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A kind of preparation method of toothpaste capable of repairing tooth enamel

A tooth enamel and toothpaste technology, applied in daily chemical products and medical fields, can solve the problems of low concentration of free calcium ions and phosphate ions, and low remineralization rate

Active Publication Date: 2022-07-08
YUNNAN BAIYAO GRP HEALTH PROD CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, directly adding calcium salts and phosphates to toothpaste, toothpaste can provide a lower concentration of free calcium ions and phosphate ions, and the rate of remineralization on tooth enamel is smaller when brushing time and frequency are limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1) Preparation of water-in-oil-in-water emulsion containing soluble calcium salt

[0025] Add 0.02 g of sucrose fatty acid ester to 100 g of rapeseed oil, heat to 30° C. and stir to obtain an oil phase. Then, 0.5 ml of 0.1% calcium chloride solution and 9.5 ml of rapeseed oil containing sucrose fatty acid ester were heated to 80°C for mixing, and stirred at a speed of 300 rpm for 120 minutes with a high-speed disperser to obtain a water-in-oil emulsion .

[0026] An aqueous phase was prepared by adding 5 grams of sodium dodecyl sulfate to 100 grams of water. 0.5 ml of the prepared water-in-oil emulsion and 9.5 ml of the water phase were heated to 30° C. for mixing, and stirred at a speed of 24,000 rpm for 0.5 minutes with a high-speed disperser to obtain a water-in-oil-in-water emulsion containing soluble calcium salts.

[0027] 2) Preparation of a water-in-oil-in-water emulsion containing soluble phosphate.

[0028] Add 5 grams of sucrose fatty acid ester to 100 gra...

Embodiment 2

[0034]This example is the same as Example 1, except that the surfactants (other surfactants other than Example 1) used in the preparation of the water-in-oil emulsion are Span60, Span65, glyceryl stearate, water loss Sorbitol monostearate, sorbitan monopalmitate, sodium stearoyl lactylate, calcium stearoyl lactylate, glyceryl rosin, sucrose acetate, sucrose isobutyrate, Span80, polyoxyethylene xylitol Monostearate, Hydrogenated Rosin Glycerides, Diacetyl Tartaric Acid Mono and Diglycerides, Propylene Glycol Fatty Acid Esters, Dipolyglycerol Monostearate, Monoglycerides, Tripolyglycerides, Propylene Glycol Fatty Acid Esters, Soy Lecithin , one of lauric acid monoglyceride, or sucrose fatty acid ester, Span60, Span65, glyceryl stearate, sorbitan monostearate, sorbitan monopalmitate, sodium stearoyl lactylate , calcium stearoyl lactylate, rosin glyceride, sucrose acetate, sucrose isobutyrate, Span80, polyoxyethylene xylitol monostearate, hydrogenated rosin glyceride, diacetyl tar...

Embodiment 3

[0037] 1) Preparation of a water-in-oil-in-water emulsion containing a soluble calcium salt.

[0038] Add 0.1 g of glyceryl stearate to 2 g of sunflower oil, heat to 80° C. and stir to obtain an oil phase. Then 1.5 ml of 60% calcium nitrate solution and 1 ml of sunflower oil containing glyceryl stearate were heated to 30°C for mixing, and stirred at a speed of 24,000 rpm for 0.5 minutes with a high-speed disperser to obtain a water-in-oil emulsion .

[0039] Add 1 gram of sodium caseinate to 4 grams of water, and stir to obtain the water phase. 1.5 ml of the prepared water-in-oil emulsion and 1 ml of the water phase were heated to 80° C. for mixing, and dispersed at a speed of 300 rpm for 120 minutes with a high-speed disperser to obtain a water-in-oil-in-water emulsion containing calcium ions.

[0040] 2) Preparation of a water-in-oil-in-water emulsion containing soluble phosphate.

[0041] Add 0.5 g of glyceryl stearate to 2 g of sunflower oil, heat to 30° C. and stir to ...

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PUM

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Abstract

A preparation method of toothpaste capable of repairing tooth enamel. In the present invention, the soluble calcium salt and the soluble phosphate are respectively wrapped in the inner water phase of the water-in-oil-in-water emulsion. The reaction produces calcium phosphate precipitates. When the toothpaste of the present invention is used to brush teeth, the water-in-oil-in-water emulsion breaks under the action of friction and extrusion, and releases the soluble calcium salts and / or soluble phosphates encapsulated in the inner water phase, so that the oral fluid contains higher Concentration of calcium ions and phosphate ions can increase the rate of remineralization of enamel and dentin in the oral cavity.

Description

technical field [0001] The invention belongs to the technical field of medical and daily chemical products, and in particular relates to a tooth composition (dentin, enamel) mineralization (biomimetic mineralization, remineralization) restoration, that is, a preparation method of toothpaste capable of restoring enamel. Background technique [0002] Tooth enamel is the hardest tissue in the human body. As the outermost layer of teeth, enamel is subjected to various physical and chemical erosions, such as occlusion, friction, abrasion, and acid erosion from diet and bacteria. Hydroxyapatite dissolves at pH < 5.5 to produce enamel. Demineralization problem. [0003] Saliva contains calcium ions and phosphate ions, which buffer the pH value of saliva to a certain extent, thereby inhibiting the dissolution of hydroxyapatite. When pH > 5.5 and the concentration of calcium ion and phosphorus ion are high, calcium phosphate is generated in saliva, so that demineralized teeth...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/06A61K8/19A61K8/24A61K8/365A61Q11/00A61P1/02
CPCA61K8/06A61K8/19A61K8/24A61K8/365A61Q11/00A61P1/02A61K8/066A61K8/375A61K8/92A61K2800/5922A61K2800/805B01F23/41B01F23/49B01F23/48B01F23/4144
Inventor 宁科功贺拥军
Owner YUNNAN BAIYAO GRP HEALTH PROD CO LTD