Hemostatic material for infants and preparation method thereof

Abstract

The invention discloses a hemostatic material for infants. The hemostatic material is characterized by being prepared from the following raw materials in parts by weight: 5 to 10 parts of a sodium-beta-cyclodextrin metal organic framework, 50 to 60 parts of 4-hydroxybutyl acrylate glycidyl ether-modified hyperbranched polylysine, 1 to 2 parts of allyl B-D glucopyranoside-modified graphene quantumdots, 8 to 12 parts of incense ash, 1 to 3 parts of 4-methacrylamide salicylic acid, 0.5 to 1.5 parts of a coupling agent and 0.05 to 0.08 part of an initiator. The invention also discloses a preparation method of the hemostatic material for infants. The hemostatic material for infants disclosed by the invention is remarkable in hemostatic effect, high in hemostatic efficiency, small in irritationto infant tissues, high in safety and small in toxic and side effects, and has a relatively high clinical practical value.

Description

technical field [0001] The invention relates to the technical field of hemostatic materials, in particular to a hemostatic material for infants and a preparation method thereof. Background technique [0002] The skin of infants and young children differs significantly from adult skin in structure, function, and composition. Its skin structure and function are still in a state of continuous growth and improvement, and it is relatively delicate and fragile. In daily life, if it accidentally falls, bumps, or is severely burned, it can easily cause bleeding from the baby's wound. Blood is one of the basic substances that constitute the human body and maintain human life activities. It has the functions of nourishing tissues, regulating organ activities and defending against harmful substances. If the human body bleeds too much, it will cause shock, and if it is more serious, it will cause life-threatening. At the same time, bleeding is accompanied by Pain, inflammation, etc. T...

AI Technical Summary

Problems solved by technology

However, although fibrin glue has good adhesion, it cannot be used alone for hemostasis on large wounds because it cannot be compressed to stop bleeding. In addition, it is easy to cause allergies and viral infections because it is derived from the blood of animals and humans; The structure makes it have a strong absorption effect on blood, activates platelets, and promotes thrombus formation, but its adhesion to visceral trauma sites is poor, and its degradation and absorption in the body are poor, which greatly increases the risk of infection at the wound site ; Although chitosan has a certain antibacterial and hemostatic effect, the hemostatic effect on larger bleeding sites is not ideal due to the limited hemostatic effect

Other hemostatic materials in the prior art, such as zeolite and oxidized regenerated cellulose, are likely to cause tissue necrosis, and cyanoacrylate, glutaraldehyde-albumin Bioglue, and cellulose ethers are likely to cause local adhesions

[0004] Chinese patent document CN108619556A discloses a preparation method of a porous fiber composite hemostatic material, which is mainly composed of modified zeolite and modified starch loaded on the modified zeolite. Deformation treatment, finally through coagulation, pelleting, and sieving, the composite hemostatic material can stop bleeding quickly, but the hemostatic effect on complex wounds is not good

[0005] The patent application number 201410097478.0 discloses a preparation method of absorbable and degradable starch hemostatic material, which is made of modified starch by inactivating, devirusing and denaturing starch, and then combining with other biological materials to prepare membrane products or sponge products. The hemostatic material can be absorbed and degraded, and can be directly applied to various complex wounds, but the hemostatic effect can only be achieved through physical effects, and the modified starch is also susceptible to pyrogenic bacterial infection