The construction and application of catalytic nanoparticles based on glucose oxidase/iron phosphate

A glucose oxidase and nanoparticle technology, applied in the field of nanodiagnostic agent preparation, can solve the problems of insufficient Fenton reaction to maintain high efficiency, Fenton reaction obstruction, etc., and achieve enhanced chemodynamic therapy, significant inhibitory effect, and mild preparation process. Effect
CN111450270BActive Publication Date: 2022-05-27SOUTHWEST UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTHWEST UNIV
Publication Date
2022-05-27

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Abstract

The invention relates to the construction and application of a catalytic nanoparticle based on glucose oxidase / iron phosphate, comprising: preparing polydopamine nanoparticles; loading glucose oxidase, bovine serum albumin and iron phosphate on the polydopamine nanoparticles in sequence . Among them, glucose oxidase can consume glucose at the tumor site to generate gluconic acid and hydrogen peroxide to achieve starvation therapy; iron phosphate can generate ferrous iron under the reducing effect of polydopamine; hydrogen peroxide can be decomposed by divalent iron under acidic conditions Iron catalyzes the generation of highly toxic hydroxyl radicals to achieve self-enhanced chemodynamic therapy; polydopamine can respond to near-infrared light to achieve low-temperature photothermal therapy with the assistance of starvation therapy. Under the guidance of photoacoustic imaging, the obtained composite nanoparticles can achieve significant inhibition of tumor growth through the combination therapy of three modalities, and provide new ideas for the diagnosis and treatment of malignant tumors.
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Description

technical field

[0001] The invention belongs to the field of preparation of nano-diagnostic agents for tumors, in particular to the construction of a catalytic nano-particle based on glucose oxidase / iron phosphate, and its application in tumor photoacoustic imaging / starvation therapy / chemodynamic therapy / low temperature photothermal therapy diagnostic applications. Background technique

[0002] Chemodynamic therapy (CDT), proposed in 2016, is considered to be a promising tumor therapy. Using the chemical energy in metal ion-mediated Fenton or Fenton-like reactions, hydrogen peroxide (H 2 O 2 ) produces highly toxic hydroxyl radicals ( OH). This strategy has pH and H 2 O 2 It shows high tumor specificity depending on the intrinsic characteristics. These characteristics enable CDT to have better biocompatibility and lower toxicity to normal tissues. In addition, compared to other reactive oxygen species (ROS)-based strategies such as photodynamic therapy (requiring exte...

Claims

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