Bone filling prosthesis and preparation technology thereof

A prosthesis and process technology, applied in the direction of prosthesis, bone implants, medical science, etc., can solve the problems of osseointegration and infection, tissue damage, poor support ability, etc., and improve the antibacterial and bacteriostatic performance and biological Active, promoting bone formation, inhibiting bone resorption

Inactive Publication Date: 2021-03-26
天衍医疗器材有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Heart medullary decompression combined with implant support therapy is the main treatment strategy at present. Commonly used implants include autologous bone, allogeneic bone, metal support rods, etc., simple autologous bone, allogeneic bone, calcium phosphate Bone implant materials absorb quickly, have poor support ability, and have poor long-term effect; metal support rods such as tantalum metal rods can provide mechanical support, but because tantalum metal has no biological activity, the bone ingrowth effect is not good, which is not conducive to support rods and tantalum metal rods. Integrative reconstruction of surrounding bone tissue
The published invention patent CN109771102A provides an improved cage-type filling rod, which adds an anti-exit mechanism, a central bone graft hole, etc., but it is still an inert titanium alloy and has no antibacterial function
Published invention patents CN110680565A and CN110680564A structurally improve this bone implant to solve the stability problem, but this structural change still cannot change the problems of osseointegration and infection
In addition, the implant rod exists in the human body for a long time. For example, the titanium alloy prosthesis is corroded, and the metal ions such as Al and V are precipitated, causing damage to the tissue. Due to bacterial infection, the consequences for the patient are fatal. At present, The vast majority of metal bone implants do not have life activity and antibacterial and antibacterial functions

Method used

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  • Bone filling prosthesis and preparation technology thereof
  • Bone filling prosthesis and preparation technology thereof
  • Bone filling prosthesis and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1. Step 1. Prepare a bone filling prosthesis with a gradient pore structure. The pore diameter of the gradient pore structure is 200 μm, the porosity of the outer pore layer is 60%, the porosity of the middle pore layer is 60%, and the porosity of the central pore layer is 60%. The porosity is 90%;

[0047] Step 2. Cleaning and drying: First, ultrasonically clean the bone filling prosthesis with acetone for 5 minutes, then spray and rinse it with deionized water, and finally dry it at 40°C;

[0048] Step 3, oxidation treatment includes:

[0049] 1) Prepare a micro-arc oxidation electrolyte, which includes 0.015mol / L sodium hexametaphosphate, 0.14mol / L sodium hydroxide, 0.4mol / L calcium element, and 0.25mol / L phosphorus by volume in the electrolyte Elements, Ca element comes from calcium acetate; P element comes from sodium glycerophosphate;

[0050] 2) Oxidation film formation, with the bone filling prosthesis as the anode and stainless steel as the cathode...

Embodiment 2

[0059] Example 2, step 1, preparing a bone filling prosthesis with a gradient pore structure, the pore diameter of the gradient pore structure is 800 μm, the porosity of the outer pore layer is 60%, the porosity of the middle pore layer is 80%, and the porosity of the central pore layer is 800 μm. The porosity is 90%;

[0060] Step 2. Cleaning and drying: First, ultrasonically clean the bone filling prosthesis with acetone for 10 minutes, then spray and rinse it with deionized water, and finally dry it at 40°C;

[0061] Step 3, oxidation treatment includes:

[0062] 1) Prepare a micro-arc oxidation electrolyte, which includes 0.015mol / L sodium hexametaphosphate, 0.14mol / L sodium hydroxide, 0.6mol / L calcium element, and 0.875mol / L phosphorus in parts by volume. Elements, Ca element comes from calcium chloride and calcium dihydrogen phosphate; P element comes from sodium dihydrogen phosphate and disodium hydrogen phosphate;

[0063] 2) Oxidation film formation, with the bone f...

Embodiment 3

[0072] Example 3, step 1, preparing a bone filling prosthesis with a gradient pore structure, the pore diameter of the gradient pore structure is 500 μm, the porosity of the outer pore layer is 60%, the porosity of the middle pore layer is 65%, and the porosity of the central pore layer The porosity is 90%;

[0073] Step 2. Cleaning and drying: First, ultrasonically clean the bone filling prosthesis with acetone for 7 minutes, then spray and rinse it with deionized water, and finally dry it at 40°C;

[0074] Step 3, oxidation treatment includes:

[0075] 1) Prepare the micro-arc oxidation electrolyte, which includes 0.015mol / L sodium hexametaphosphate, 0.14mol / L sodium hydroxide solution, 0.5mol / L calcium element, and 0.65mol / L phosphorus in the electrolyte by volume. Elements, Ca element comes from calcium lactate and calcium oxide; P element comes from sodium hexametaphosphate and sodium polyphosphate;

[0076] 2) Oxidation film formation, with the bone filling prosthesis ...

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Abstract

The invention discloses a bone filling prosthesis and a preparation technology thereof. The bone filling prosthesis is of a gradient pore structure of which the pore diameter is 200-800 [mu]m. The bone filling prosthesis comprises an outer-layer pore layer, a middle pore layer and a central pore layer, wherein the porosity of the outer-layer pore layer is 60%, the porosity of the middle pore layeris 60-80%, and the porosity of the central pore layer is 90%. The preparation technology of the bone filling prosthesis comprises the following steps of: preparing the bone filling prosthesis with the gradient pore structure, carrying out cleaning and drying, carrying out oxidation treatment, carrying out alkali-heat treatment, carrying out ultraviolet antibacterial treatment, and carrying out secondary cleaning and drying. By use of the bone filling prosthesis and the preparation technology thereof, one layer of in situ membrane layer is formed on the surface of the bone filling prosthesis so as to be favorable for bone ingrowth, the bone filling prosthesis is endowed with anti-bacteria and bacteria-inhibition performance and biological activity, the membrane layer contains anti-bacteriaelements, and the bone filling prosthesis has an anti-bacteria function while the bone filling prosthesis has the biological activity.

Description

technical field [0001] The invention relates to the field of prosthesis processing, in particular to a bone filling prosthesis and a preparation process thereof. Background technique [0002] Osteonecrosis of the femoral head is a multipathological mechanism that ultimately leads to the same outcome. It is a multifactorial disease that leads to bone marrow cell ischemia and osteonecrosis. It mainly occurs in young people. The etiology includes alcoholism, history of hormone drug use, trauma, etc. Early femoral head necrosis, if not treated in time, further development will lead to bone collapse, and eventually total hip replacement has to be performed. Since femoral head necrosis mostly occurs in young and middle-aged patients, it is not suitable for premature total hip replacement. Therefore, Early delay of femoral head necrosis and prevention of disease progression are the key to postponing total hip replacement. [0003] Heart medullary decompression combined with implan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28
CPCA61F2/28A61F2/30767A61F2002/2835A61F2002/30769
Inventor 魏崇斌黄朝阳王健荣鑫毛联甲闵信群
Owner 天衍医疗器材有限公司
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