Whole blood perfusion adsorbent as well as preparation method and application thereof

Abstract

The invention belongs to the field of natural polymer biomedical materials, and particularly relates to a whole blood perfusion adsorbent as well as a preparation method and application thereof; the adsorbent is large-size nanofiber porous network microspheres compounded by natural polymer nanofibers, an inorganic functional filler, an organic functional filler and / or an organic coating material, wherein the inorganic functional filler and the organic functional filler are wrapped in the natural polymer nanofiber microspheres, and the organic coating material coats the surfaces of the natural polymer nanofiber microspheres. The whole blood perfusion adsorbent has a microsphere size suitable for whole blood perfusion, has good blood compatibility, has a nanofiber porous network structure, is an inorganic and organic functional material capable of specifically adsorbing toxins, can be designed for specific toxins, and is high in adsorption efficiency, high in selectivity and easy to popularize and apply.

Description

technical field [0001] The invention belongs to the field of natural polymer biomedical materials, and in particular relates to a whole blood perfusion adsorbent, its preparation method and application. Background technique [0002] Hemoperfusion (HP) is a blood purification technology developed after hemodialysis. ) has achieved rapid development. This method is to directly remove toxins and pathogenic factors (such as bilirubin, bile acid, creatinine, blood ammonia, endotoxin or immune system) in the blood through the adsorbent with special adsorption function in the extracorporeal hemoperfusion device and the extracorporeal blood circulation system. It is a blood purification technology with great development potential, and blood purification has also played an important role in the treatment of severe new crown patients. The market demand is huge, but the existing market products are single, key technology breakthroughs are difficult, safety and effectiveness are diffi...

AI Technical Summary

Problems solved by technology

However, due to the strong basic group of anion exchange resin, it has an impact on various components in blood, blood cells, electrolyte balance and coagulation system, etc., and it is easy to cause more side reactions. When using it, the blood needs to be separated. The plasma part in the blood is perfused and adsorbed without contacting the cell components in the blood, but it will still have a certain impact on the protein, coagulation factors and other components in the plasma, which not only increases the treatment cost, but also has low safety and many side effects

Neutral resins have little effect on blood components and can be used for whole blood perfusion. Its macroporous structure is conducive to the diffusion and adsorption of large-sized toxins. Therefore, macroporous neutral resins can be used for whole blood perfusion to remove bilirubin Medium-molecular toxins can reduce overall treatment costs and reduce operational risks, but the effect of removing bilirubin and other toxins is not obvious, the specific adsorption capacity is extremely low, and the practical application value is small, and the raw materials of this type of material are toxic and easy to pollute the environment , the preparation process is also very easy to produce pollutants and waste, and it cannot be degraded after use, which is easy to cause serious environmental pollution and damage, and imposes a heavy burden on the ecological environment and economy. At this stage, environmentally friendly and efficient products are urgently needed to replace

[0006] As an auxiliary means of disease treatment, hemoperfusion has been affirmed by the industry for its curative effect and has gradually gained favor in the market. However, the effective hemoperfusion adsorber products at home and abroad are still mainly anion exchange resins, which can only be used for plasma perfusion. Some side effects, safety and effect are difficult to meet the needs of the majority of patients, and the price is expensive, which increases the financial burden on patients

At present, there is no one with excellent adsorption effect, strong selective removal ability, wide range of toxin removal, good biocompatibility and blood compatibility, low price, green environmental protection, renewable utilization, degradable, and can be used in the whole world. Adsorbent materials for hemoperfusion, such highly efficient and friendly whole hemoperfusion adsorbent materials are urgently needed in clinic to relieve the pain of patients, reduce the overall treatment cost, and increase the efficacy and safety of treatment

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