Antitumor drug-loaded artificial bone material and method for preparing artificial bone

An anti-tumor drug, artificial bone technology, applied in the field of biomedical material preparation and molding, can solve the problems of less than 20% survival rate, affecting the quality of life, high mortality, and achieve inhibition of tumor recurrence and metastasis, low material cost, bone good inductive effect

Pending Publication Date: 2021-06-04
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the treatment of bone tumors, amputation or local extensive resection and radiotherapy were mainly used before the chemotherapy program was carried out, which caused great harm to patients, seriously affected the quality of life after surgery, and had a high mortality rate, and the 5-year survival rate was insufficient. 20%
However, the current bioceramic preparation materials imitate the inorganic components of natural bone, which can meet the requirements of natural bone in terms of porosity, pore size and compressive strength, but the toughness endowed by organic components is the deficiency of bioceramic materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The particle size of β-TCP (hydroxyapatite) particle diameter is 0.8 um, medical grade collagen powder, deionized water, polyacethamine, methotrexate, ammonium chloride mixed to form ink slurry; where poly The araceramine is 0.6% of the β-TCP dry powder content, and the amount of ammonium chloride is 0.06% of the ink mass, the methotrexate concentration is 6 mg / ml, and the phosphoric acid regulates the pH of 4. The solid phase solid phase content obtained was 44%.

[0028] The mixed slurry is placed on a ball mill with a 90 RMP tension ball milling 24h, and the ultrasonic oscillation 12H is obtained, i.e., obtain the desired ink suspension. The income ink suspension has a good shear and dilute, at 10S -1 The viscosity at the shear speed is 2Pa · s; has good viscoelastic, which is up to 10 in 1PA elastic modulus. 3 PA, has good conformability, can be smoothly blocked by needle mouth and maintain a three-dimensional stereo shape.

[0029] The ink suspension is loaded into t...

Embodiment 2

[0032] The hydroxyapatite particle diameter is 1 um, medical grade collagen powder, deionized water, polyacrylic acid, doxorubicin, zinc acetate mixed to form ink slurry; wherein polyacrylic acid is 0.8% of hydroxyapatite dry powder content, acetic acid The amount of zinc is 0.05% in the ink mass, and the polyxin concentration is 10 mg / ml, and the pH of magnesium hydroxide is adjusted to 9. The obtained ink slurry solid phase content was 56%.

[0033] The mixed slurry is placed on a ball mill on a 100 RMP tension ball milling, and the ultrasonic oscillation 12H is obtained, i.e., obtain the desired ink suspension. The income ink suspension has a good shear and dilute, at 10S -1 The viscosity at the shear speed is 3Pa · s); it has good viscoelasticity, which is up to 10 in 10PA elastic modulus. 3 PA, has good conformability, can be smoothly blocked by needle mouth and maintain a three-dimensional stereo shape.

[0034] The ink suspension is loaded into the blower of the 3D directio...

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Abstract

The invention discloses an antitumor drug-loaded artificial bone material and a method for preparing an artificial bone. The method comprises the following steps of: dissolving hydroxyapatite particles, collagen powder, a dispersing agent, an antitumor drug and trace elements in deionized water, adjusting the pH value, and uniformly mixing to obtain slurry; performing ball milling and ultrasonic oscillation on the slurry to obtain an ink suspension; and filling the ink suspension into a spray cylinder of 3D direct writing forming equipment, connecting a computer with the direct writing forming equipment, setting a program of the 3D direct writing equipment and a bone-like structure model, controlling the rheological property of the ink suspension, printing in air in a layer-by-layer overlapping manner, and drying to obtain the antitumor drug-loaded artificial bone material. The artificial bone material disclosed by the invention can achieve dual effects of repairing bone defects and a drug carrier, has excellent biocompatibility and bone regeneration inducing capacity, and can achieve the effects of improving the local drug concentration of the antitumor drug, relieving systemic drug response and inhibiting tumor recurrence and metastasis.

Description

Technical field [0001] The present invention belongs to the formation of a biomedical material, and is specifically involved in a method of anti-tumor pharmaceutical artificial bone material and a method of preparing artificial bone. Background technique [0002] Bone tissue malignant tumors are common in the clinical, in the primary bone malignant tumors, the top four of the incidence is pulverized cytoplasm, osteosarcoma, chondrosarcoma and Juwen sarcoma. In addition, bone tissue is still a third transfer of a systemic malignant tumor, common in lung cancer, prostate cancer and bone metastasis of breast cancer. For the treatment of bone tumors, before the chemotherapy solution is carried out, it is mainly amputated or local extensive resection and radiotherapy. It has caused great damage to the patient. It has seriously affecting postoperative quality of life, and the mortality rate is also high, and the 5-year survival rate is insufficient. 20%. With the development of chemoth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/24A61L27/54A61L27/50B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/12A61L27/24A61L27/54A61L27/50B33Y10/00B33Y70/10B33Y80/00A61L2430/02A61L2300/416
Inventor 朱剑熹朱勇胡懿郃王佳豪廖晶晶贺泰来龙承肖瑶韩斐
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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