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Disordered porous biological ceramic scaffold based on photocuring three-dimensional printing as well as preparation method and application of disordered porous biological ceramic scaffold

A technology of bioceramics and porous scaffolds, which is applied in the field of biomedical materials, can solve the problems of complex post-processing, difficulty in controlling the size of microstructures, and low precision, and achieve good osteoinductive effects, rapid repair, and rapid cell proliferation.

Active Publication Date: 2021-06-04
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the efficiency of the slurry layer casting / direct writing assembly technology is low, and the molding accuracy is limited by the equipment nozzle, and it is difficult to control the size of the microstructure; the ceramic material of the binder injection molding has poor density and low precision; laser selection The ceramic material obtained by sintering has a loose structure and internal stress, and the post-processing is complicated; the light-curing molding process can produce parts with relatively complex structures due to its high molding precision and excellent surface quality.

Method used

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  • Disordered porous biological ceramic scaffold based on photocuring three-dimensional printing as well as preparation method and application of disordered porous biological ceramic scaffold
  • Disordered porous biological ceramic scaffold based on photocuring three-dimensional printing as well as preparation method and application of disordered porous biological ceramic scaffold
  • Disordered porous biological ceramic scaffold based on photocuring three-dimensional printing as well as preparation method and application of disordered porous biological ceramic scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1, preparation of disordered structure β-tricalcium phosphate ceramic scaffold

[0074] 1. Design a porous ceramic scaffold model with a disordered structure inside ( figure 1 (a)), and perform model reading and parameter design in the device.

[0075] 2. Preparation of photosensitive resin premix: bisphenol A glycidyl methacrylate, triethylene glycol dimethacrylate, propoxylated neopentyl glycol diacrylate, 2,4,6-trimethyl The benzoyl-diphenylphosphine oxide (TPO) is fully mixed to obtain a photosensitive resin premix. Among them, bisphenol A glycidyl methacrylate content is 65wt%, 2,4,6-trimethylbenzoyl-diphenylphosphine oxide (TPO) content is 2.5wt%, triethylene glycol dimethyl The mass ratio of acrylate to propoxylated neopentyl glycol diacrylate is 6:4.

[0076] 3. Slurry preparation: Add the photosensitive resin premix solution obtained in step 2, dispersant BYK-111, propylene glycol methyl ether, and β-tricalcium phosphate into a polytetrafluoroethy...

Embodiment 2

[0090] Embodiment 2, the preparation of feldspar / magnesium silicate ceramic support

[0091] 1. Design a porous ceramic scaffold model with a disordered structure inside ( image 3 (a)), and perform model reading and parameter design in the device.

[0092] 2. Slurry preparation: Add Osborne A370 photosensitive resin (transparent), dispersant KH-560, magnesian feldspar, and magnesium silicate into a polytetrafluoroethylene ball mill tank for ball milling, and the slurry is obtained immediately after ball milling. Among them, the content of Osborne A370 photosensitive resin (transparent) is 30wt%, the content of KH-560 is 15wt%, and the mass ratio of feldspar and magnesium silicate is 1:1.

[0093] 3. Put the slurry obtained in step 2 into a light-curing printer, and perform printing and molding according to the set parameters.

[0094] 4. Use absolute ethanol to clean the printed samples.

[0095] 5. The green body cleaned in step 4 is degummed and degreased at 500°C for 3 ...

Embodiment 3

[0098] Embodiment 3, the preparation of wollastonite / calcium silicate ceramic support

[0099] 1. Design a porous ceramic scaffold model with a disordered structure inside ( Figure 4 (a)), and perform model reading and parameter design in the device.

[0100] 2. Slurry preparation: Add Osborne A370 photosensitive resin (transparent), dispersant KH-550, propylene glycol methyl ether, white wollastonite and calcium silicate into a polytetrafluoroethylene ball mill tank for ball milling, and the slurry is obtained after ball milling material. Among them, the content of Osborne A370 photosensitive resin (transparent) is 28wt%, the content of dispersant KH-550 is 10wt%, the content of propylene glycol methyl ether is 10wt%, and the mass ratio of wollastonite and calcium silicate is 3:7.

[0101] 3. Put the slurry obtained in step 2 into a light-curing printer, and perform printing and molding according to the set parameters.

[0102] 4. Use absolute ethanol to clean the printed...

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Abstract

The invention discloses a disordered porous biological ceramic scaffold based on photocuring three-dimensional printing as well as a preparation method and application of the disordered porous biological ceramic scaffold. The preparation method of the disordered porous biological ceramic scaffold comprises the following steps: designing porous scaffold three-dimensional models with different physical structures; mixing biological ceramic, photosensitive resin and a dispersing agent, and performing ball milling to obtain biological ceramic slurry for forming; inputting the porous scaffold three-dimensional model into a photocuring printer, taking the biological ceramic slurry as a raw material, and adopting the photocuring printer for printing and forming to obtain a porous biological ceramic scaffold blank; cleaning and drying the porous biological ceramic scaffold green body to obtain a porous biological ceramic scaffold green body; and sequentially degreasing, pre-sintering and sintering the porous biological ceramic scaffold green body to obtain the porous biological ceramic scaffold. The porous biological ceramic scaffold with the disordered internal structure, prepared by the invention, has physical structures with different angles, so that cells are subjected to different physical stimulations, meanwhile, more anchoring points are provided for the cells, the cell proliferation is faster, and rapid repair of bone defects is facilitated.

Description

technical field [0001] The invention relates to a disordered porous bioceramic support based on photocuring three-dimensional printing and its preparation method and application, belonging to the field of biomedical materials. Background technique [0002] Bone defects caused by various reasons such as trauma, infection, tumor resection, etc. are one of the problems faced by orthopedics, maxillofacial surgery and other departments. Bone graft surgery is usually required in the treatment process. With the development of bone tissue engineering and materials science, the research and application of porous bioceramic scaffolds in the direction of bone defect repair are increasing. In order to achieve a good repair effect, general porous bioceramic scaffolds usually have good biocompatibility, high porosity, high pore connectivity, and a pore size suitable for bone ingrowth. At the same time, in the process of gradually inducing bone cells to grow into the scaffold to complete ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/22C04B35/20C04B35/195C04B35/622C04B38/00A61L27/10A61L27/56A61L27/58B33Y70/10B33Y10/00B33Y80/00
CPCC04B35/447C04B35/22C04B35/20C04B35/195C04B35/622C04B38/0003A61L27/10A61L27/56A61L27/58B33Y70/10B33Y10/00B33Y80/00A61L2430/02C04B2235/3212C04B2235/656C04B2235/6567C04B38/0074C04B38/0051C04B38/0054Y02P10/25
Inventor 陈洋陈振华徐秀张影黄玲王彬刘启省张东刚
Owner YANTAI ZHENGHAI BIO TECH