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Natto fermentation composition for relieving arteriosclerosis as well as preparation method and application of natto fermentation composition

A fermented composition and technology of arteriosclerosis, applied in the field of bioengineering, can solve problems such as lack of widespread application, achieve good inhibitory and therapeutic effects, wide source of raw materials, and simple preparation method

Active Publication Date: 2021-06-22
天津市宝恒生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many prescriptions have been clinically used to relieve or treat arteriosclerosis, they have not been widely used so far.

Method used

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  • Natto fermentation composition for relieving arteriosclerosis as well as preparation method and application of natto fermentation composition
  • Natto fermentation composition for relieving arteriosclerosis as well as preparation method and application of natto fermentation composition
  • Natto fermentation composition for relieving arteriosclerosis as well as preparation method and application of natto fermentation composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation method of embodiment 1 natto fermentation extract

[0032] Specifically include the following steps:

[0033] S1. Preparation of strain seed liquid: Inoculate 1 g of Monascus, 7 g of Bacillus natto and 2 g of Morchella into Gaulian culture medium for streaking, the first aerobic culture, the culture condition is 36°C, 22%, the humidity is 70%, and the cultivation time is 12h, respectively cultivated into the strain seed liquid, and the bacterial content of the strain seed liquid is 10 8 cfu / mL;

[0034] S2. Preparation of notoginseng powder: wash and dry notoginseng and pulverize to 100 mesh to obtain notoginseng powder, which is sterilized by ultraviolet light for later use;

[0035] S3. Preparation of semi-solid medium: Dissolve 4g of glucose, 5g of urea, 0.1g of vitamin K, 0.05g of vitamin C, 0.2g of ferric chloride, and 0.2g of zinc sulfate in 100mL of sterile water. Seven powder, use PBS solution to adjust the pH value of the medium to 6.8, and s...

Embodiment 2

[0040] The preparation method of embodiment 2 natto fermentation extract

[0041] Specifically include the following steps:

[0042] S1. Preparation of bacterial strain seed liquid: Inoculate 5g of Monascus, 12g of Bacillus natto and 4g of Morchella into Gao's culture medium to mark the line, the first aerobic culture, the culture condition is 38 ℃, The humidity is 30%, the humidity is 80%, and the cultivation time is 24h, respectively cultivated into the strain seed liquid, and the bacterial content of the strain seed liquid is 10 9 cfu / mL;

[0043] S2. Preparation of notoginseng powder: wash and dry notoginseng and pulverize to 100 mesh to obtain notoginseng powder, which is sterilized by ultraviolet light for later use;

[0044] S3. Preparation of semi-solid medium: 12g sucrose, 5g ammonium nitrate, 3g cysteine, 2g methionine, 0.3g vitamin C, 0.5g calcium chloride, 0.3g magnesium sulfate, 0.4g zinc sulfate were used in 100mL Dissolve in sterile water, mix evenly, add 12g...

Embodiment 3

[0049] The preparation method of embodiment 3 natto fermented extract

[0050] Specifically include the following steps:

[0051] S1. Preparation of strain seed liquid: Inoculate 3.5g of Monascus, 10g of Bacillus natto and 3g of Morchella into Gao's culture medium to mark the line, and perform aerobic culture for the first time. The culture condition is 37°C, oxygen The content is 27%, the humidity is 75%, and the cultivation time is 16h, respectively cultivated into the strain seed liquid, and the bacterial content of the strain seed liquid is 10 9 cfu / mL;

[0052] S2. Preparation of notoginseng powder: wash and dry notoginseng and pulverize to 100 mesh to obtain notoginseng powder, which is sterilized by ultraviolet light for later use;

[0053] S3. Preparation of semi-solid medium: mix 9g maltose, 5g urea, 2g glutamic acid, 0.02g vitamin K, 0.1g vitamin B2, 0.1g vitamin A and 0.2g manganese sulfate, 0.2g zinc chloride, 0.2g chlorine Dissolve copper chloride and 0.2g mang...

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Abstract

The invention provides a natto fermentation composition for relieving arteriosclerosis as well as a preparation method and application of the natto fermentation composition, and belongs to the technical field of bioengineering. The natto fermentation composition for relieving arteriosclerosis is prepared from the following raw materials in parts by weight: 70-120 parts of natto fermentation extract, 1-2 parts of ginsenoside Re, 7-12 parts of notoginsenoside S and 10-20 parts of cyclocarya paliurus flavone. The preparation method disclosed by the invention is simple, the raw materials are wide in source, and the prepared composition has good effects of reducing blood fat and dissolving thrombus; in particular, the compound has good inhibition and treatment effects on atherosclerosis, is safe and free of side effects, can be used as a raw material of dietary therapy products, health-care foods and medicines, and has a wide application prospect.

Description

technical field [0001] The invention relates to the technical field of bioengineering, in particular to a fermented natto composition for relieving arteriosclerosis, a preparation method and application thereof. Background technique [0002] Arteriosclerosis is an inflammatory lesion of the arteries, which can thicken and harden the arterial wall, lose its elasticity, and narrow the lumen. Arteriosclerosis is a vascular disease that occurs as people grow older. It usually occurs in adolescence and aggravates and develops in middle-aged and old age. With the improvement of people's living standards, the incidence of cardiovascular arteriosclerosis has gradually increased, and it has become one of the main causes of death in the elderly. Atherosclerosis (Atherosclerosis, AS) is the most common and important type of arteriosclerosis, which is characterized by the deposition of lipids and the accumulation of complex carbohydrates in the intima of the affected arteries, followed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61K36/48A61P9/10A23L33/105A23L33/125A61K31/704
CPCA61K36/48A61K31/704A61K36/52A61P9/10A23L33/105A23L33/125A61K2236/19A23V2002/00A23V2200/326A23V2250/21A23V2250/51A23V2250/2116A23V2250/2124A61K2300/00
Inventor 李宝恒李倩舒威
Owner 天津市宝恒生物科技有限公司
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